日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF

USP7抑制剂通过下调成纤维细胞VEGF来抑制肿瘤新生血管生成并促进与免疫检查点抑制剂的协同作用。

期刊:Clinical and Translational Medicine
影响因子:7.9
doi:10.1002/ctm2.1648
Anamarija Jurisic ，Pei-Ju Sung ，Mark Wappett ，Julien Daubriac ，Ian T Lobb ，Wei-Wei Kung ，Nyree Crawford ，Natalie Page ，Eamon Cassidy ，Stephanie Feutren-Burton ，J S Shane Rountree ，Matthew D Helm ，Colin R O'Dowd ，Richard D Kennedy ，Gerald Gavory ，Aaron N Cranston ，Daniel B Longley ，Xavier Jacq ，Timothy Harrison
免疫/内分泌
血管生成
肿瘤免疫
细胞生物学
SP7
成纤维细胞
VEGF
EGF
肿瘤
发表日期：2024
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Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide]

使用 γ-分泌酶抑制剂 LY-411575 [N2-[(2S)-2-(3,5-二氟苯基)-2-羟基乙酰基]-N1-[(7S)-5-甲基-6-氧代-6,7-二氢-5H-二苯并[b,d]氮杂卓-7-基]-L-丙氨酰胺] 治疗后，定量测量大鼠脑和脑脊液中淀粉样蛋白-β(40) 的变化

期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.1
doi:10.1124/jpet.104.081174
Jonathan D Best, Mark T Jay, Franklin Otu, Jerome Ma, Alan Nadin, Semantha Ellis, Huw D Lewis, Christine Pattison, Michael Reilly, Timothy Harrison, Mark S Shearman, Toni L Williamson, John R Atack
神经科学
Rat
发表日期：2024
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Adrenal function recovery after durable oral corticosteroid sparing with benralizumab in the PONENTE study

PONENTE 研究中，贝那利珠单抗长期口服皮质类固醇治疗后肾上腺功能恢复

期刊:European Respiratory Journal
影响因子:16.6
doi:10.1183/13993003.03226-2021
Andrew Menzies-Gow, Mark Gurnell, Liam G Heaney, Jonathan Corren, Elisabeth H Bel, Jorge Maspero, Timothy Harrison, David J Jackson, David Price, Njira Lugogo, James Kreindler, Annie Burden, Alex de Giorgio-Miller, Sarai Faison, Kelly Padilla, Ubaldo J Martin, Esther Garcia Gil; PONENTE Study Group
免疫/内分泌
发表日期：2022
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Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development

鉴定和开发适合临床开发的亚型选择性变构 AKT 抑制剂

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-022-20208-5
Natalie Page, Mark Wappett, Colin R O'Dowd, Martin O'Rourke, Gerald Gavory, Lixin Zhang, J S Shane Rountree, Linda Jordan, Oliver Barker, Hayley Gibson, Caroline Boyd, Stephanie Feutren-Burton, Estelle McLean, Graham Trevitt, Timothy Harrison
信号转导
PI3K/Akt
发表日期：2022
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RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

RALB GTPase：KRAS 突变结直肠癌中 DR5 表达和 TRAIL 敏感性的关键调节剂

期刊:Cell Death & Disease
影响因子:8.1
doi:10.1038/s41419-020-03131-3
Hajrah Khawaja, Andrew Campbell, Jamie Z Roberts, Arman Javadi, Paul O'Reilly, Darragh McArt, Wendy L Allen, Joanna Majkut, Markus Rehm, Alberto Bardelli, Federica Di Nicolantonio, Christopher J Scott, Richard Kennedy, Nicolas Vitale, Timothy Harrison, Owen J Sansom, Daniel B Longley, Emma Evergren,
肿瘤
肠癌
发表日期：2020
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A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

TRAIL-R2 DISC 组装的修订模型解释了 FLIP(L) 如何抑制或促进细胞凋亡

期刊:EMBO Reports
影响因子:6.5
doi:10.15252/embr.201949254
Luke M Humphreys, Jennifer P Fox, Catherine A Higgins, Joanna Majkut, Tamas Sessler, Kirsty McLaughlin, Christopher McCann, Jamie Z Roberts, Nyree T Crawford, Simon S McDade, Christopher J Scott, Timothy Harrison, Daniel B Longley
信号转导
细胞生物学
其它细胞
Apoptosis
发表日期：2020
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Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

发现和表征高效且选择性的变构 USP7 抑制剂

期刊:Nature Chemical Biology
影响因子:12.9
doi:10.1038/nchembio.2528
Gerald Gavory, Colin R O'Dowd, Matthew D Helm, Jakub Flasz, Elias Arkoudis, Anthony Dossang, Caroline Hughes, Eamon Cassidy, Keeva McClelland, Ewa Odrzywol, Natalie Page, Oliver Barker, Hugues Miel, Timothy Harrison
信号转导
发表日期：2018
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Impact of insurance coverage on utilization of pre-exposure prophylaxis for HIV prevention

保险覆盖范围对艾滋病毒暴露前预防药物利用率的影响

期刊:PLoS One
影响因子:2.6
doi:10.1371/journal.pone.0178737
Patel, Rupa R; Mena, Leandro; Nunn, Amy; McBride, Timothy; Harrison, Laura C; Oldenburg, Catherine E; Liu, Jingxia; Mayer, Kenneth H; Chan, Philip A
HIV
微生物学
发表日期：2017
文献求助 收藏

Patient Recruitment 2.0: Become a Partner in the Patient Journey Using Digital Media

患者招募2.0：利用数字媒体成为患者就医旅程中的合作伙伴

期刊:JMIR Research Protocols
影响因子:1.5
doi:10.2196/resprot.5045
Lindemann, Michael; Freeman, Tobe; Kilchenmann, Timothy; Harrison, Shuree; Chan, Margaret; Wygonik, Mark; Haines, Lea; Gossens, Christian
发表日期：2016
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FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism

FKBPL 和肽衍生物：通过 CD44 依赖机制抑制血管生成的新型生物药剂

期刊:Clinical Cancer Research
影响因子:10
doi:10.1158/1078-0432.CCR-10-2241
Andrea Valentine, Martin O'Rourke, Anita Yakkundi, Jenny Worthington, Michelle Hookham, Roy Bicknell, Helen O McCarthy, Keeva McClelland, Lynn McCallum, Hayder Dyer, Hayley McKeen, David J J Waugh, Jennifer Roberts, Joanne McGregor, Graham Cotton, Iain James, Timothy Harrison, David G Hirst, Tracy R
信号转导
发表日期：2011
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