日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease

病理性 tau 驱动异位核斑点支架蛋白 SRRM2 在阿尔茨海默病中的神经元细胞质中积累

Pamela J McMillan, Timothy J Strovas, Misa Baum, Brooke K Mitchell, Randall J Eck, Nzinga Hendricks, Jeanna M Wheeler, Caitlin S Latimer, C Dirk Keene, Brian C Kraemer

Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes

不同的 Poly(A) 核酸酶对 sut-2 依赖性 tau 蛋白病表型有不同的影响

Rebecca L Kow, Timothy J Strovas, Pamela J McMillan, Ashley M Jacobi, Mark A Behlke, Aleen D Saxton, Caitlin S Latimer, C Dirk Keene, Brian C Kraemer

AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery

AlphaScreen 发现用于 Tau 蛋白病靶向治疗的 MSUT2 抑制剂

Jeremy D Baker, Rikki L Uhrich, Timothy J Strovas, Aleen D Saxton, Brian C Kraemer

Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA-Protein Interaction

通过小分子抑制 Poly(A):MSUT2 RNA-蛋白质相互作用来靶向病理性 Tau

Jeremy D Baker, Rikki L Uhrich, Timothy J Strovas, Aleen D Saxton, Brian C Kraemer

Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans

tau 和淀粉样蛋白之间的协同毒性导致转基因秀丽隐杆线虫的神经元功能障碍和神经退行性

Sarah J Benbow, Timothy J Strovas, Martin Darvas, Aleen Saxton, Brian C Kraemer

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain

poly(A) 结合蛋白 MSUT2 的活性决定了哺乳动物大脑对病理性 tau 的易感性

Jeanna M Wheeler, Pamela McMillan, Timothy J Strovas, Nicole F Liachko, Alexandre Amlie-Wolf, Rebecca L Kow, Ronald L Klein, Patricia Szot, Linda Robinson, Chris Guthrie, Aleen Saxton, Nicholas M Kanaan, Murray Raskind, Elaine Peskind, John Q Trojanowski, Virginia M Y Lee, Li-San Wang, C Dirk Keene,

Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy

全基因组分析揭示硫酸肝素表异构酶调节 TDP-43 蛋白病

Nicole F Liachko, Aleen D Saxton, Pamela J McMillan, Timothy J Strovas, C Dirk Keene, Thomas D Bird, Brian C Kraemer

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

TTBK1 和 TTBK2 对 tau 和 TDP-43 的病理性磷酸化导致神经退行性病变

Laura M Taylor, Pamela J McMillan, Nicole F Liachko, Timothy J Strovas, Bernardino Ghetti, Thomas D Bird, C Dirk Keene, Brian C Kraemer1

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation

磷酸酶钙调磷酸酶调节病理性 TDP-43 磷酸化

Nicole F Liachko, Aleen D Saxton, Pamela J McMillan, Timothy J Strovas, Heather N Currey, Laura M Taylor, Jeanna M Wheeler, Adrian L Oblak, Bernardino Ghetti, Thomas J Montine, C Dirk Keene, Murray A Raskind, Thomas D Bird, Brian C Kraemer

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43

tau 微管蛋白激酶 TTBK1/2 促进病理性 TDP-43 的积累

Nicole F Liachko, Pamela J McMillan, Timothy J Strovas, Elaine Loomis, Lynne Greenup, Jill R Murrell, Bernardino Ghetti, Murray A Raskind, Thomas J Montine, Thomas D Bird, James B Leverenz, Brian C Kraemer