日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Polyfunctional anti-human epidermal growth factor receptor 3 (anti-HER3) antibodies induced by HER3 vaccines have multiple mechanisms of antitumor activity against therapy resistant and triple negative breast cancers

HER3 疫苗诱导的多功能抗人表皮生长因子受体 3（抗 HER3）抗体具有多种抗肿瘤活性机制，可对抗治疗耐药性和三阴性乳腺癌

期刊:Breast Cancer Research
影响因子:6.1
doi:10.1186/s13058-018-1023-x
Takuya Osada, Zachary C Hartman, Junping Wei, Gangjun Lei, Amy C Hobeika, William R Gwin, Marcio A Diniz, Neil Spector, Timothy M Clay, Wei Chen, Michael A Morse, H Kim Lyerly
肿瘤
乳腺癌
Human
发表日期：2018
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Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells

疫苗诱导的多克隆 HER2 特异性抗体介导肿瘤细胞中的受体内化和降解

期刊:Breast Cancer Research
影响因子:6.1
doi:10.1186/bcr3204
Xiu-Rong Ren, Junping Wei, Gangjun Lei, Jiangbo Wang, Jiuyi Lu, Wenle Xia, Neil Spector, Larry S Barak, Timothy M Clay, Takuya Osada, Erika Hamilton, Kimberly Blackwell, Amy C Hobeika, Michael A Morse, H Kim Lyerly, Wei Chen
信号转导
肿瘤
肿瘤细胞
ELISA
IF
WB
Human
BLM
发表日期：2012
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Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system

侵袭性三阴性乳腺癌表型可塑性的证据：一种新的模型系统重现了人类生物学

期刊:PLoS One
影响因子:2.9
doi:10.1371/journal.pone.0045684
Nicholas C D'Amato, Julie H Ostrander, Michelle L Bowie, Christopher Sistrunk, Alexander Borowsky, Robert D Cardiff, Katie Bell, Lawrence J T Young, Karl Simin, Robin E Bachelder, Jeff Delrow, Alyssa Dawson, Lisa D Yee, Krzysztof Mrózek, Timothy M Clay, Takuya Osada, Victoria L Seewaldt
肿瘤
乳腺癌
WB
Human
发表日期：2012
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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations

抗蠕虫化合物氯硝柳胺可下调 Wnt 信号并在具有激活 APC 突变的肿瘤中引发抗肿瘤反应

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-10-3978
Takuya Osada, Minyong Chen, Xiao Yi Yang, Ivan Spasojevic, Jeffrey B Vandeusen, David Hsu, Bryan M Clary, Timothy M Clay, Wei Chen, Michael A Morse, H Kim Lyerly
肿瘤
Wnt/β-Catenin
发表日期：2011
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Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity

MyD88 异位过表达产生的配体非依赖性 Toll 样受体信号可产生局部和全身抗肿瘤免疫

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-10-0905
Zachary C Hartman, Takuya Osada, Oliver Glass, Xiao Y Yang, Gang-Jun Lei, H Kim Lyerly, Timothy M Clay
信号转导
肿瘤
Toll-Like Receptor
发表日期：2010
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Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo

体内 HER2 免疫和药物联合抑制的协同作用

期刊:International Journal of Cancer
影响因子:5.7
doi:10.1002/ijc.24995
Michael A Morse, Junping Wei, Zachary Hartman, Wenle Xia, Xiu-Rong Ren, Gangjun Lei, William T Barry, Takuya Osada, Amy C Hobeika, Sharon Peplinski, Haixiang Jiang, Gayathri R Devi, Wei Chen, Neil Spector, Andrea Amalfitano, H Kim Lyerly, Timothy M Clay
免疫
IHC
Goat
IgG
发表日期：2010
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CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer

CSPG4蛋白作为三阴性乳腺癌抗体免疫治疗的新靶点

期刊:Jnci-Journal of the National Cancer Institute
影响因子:
doi:10.1093/jnci/djq343
Xinhui Wang, Takuya Osada, Yangyang Wang, Ling Yu, Koichi Sakakura, Akihiro Katayama, James B McCarthy, Adam Brufsky, Mamatha Chivukula, Thaer Khoury, David S Hsu, William T Barry, H Kim Lyerly, Timothy M Clay, Soldano Ferrone
免疫
乳腺癌
发表日期：2010
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Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo

腺病毒感染会触发快速的 MyD88 调节转录组反应，这对体内急性期和适应性免疫反应至关重要

期刊:Journal of Virology
影响因子:4
doi:10.1128/JVI.01936-06
Zachary C Hartman, Anne Kiang, Ruth S Everett, Delila Serra, Xiao Y Yang, Timothy M Clay, Andrea Amalfitano
免疫
Sequencing
发表日期：2007
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