日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies

鉴定并进行单碱基基因编辑功能验证,以鉴定顺式EPO变体作为EPO增效疗法的遗传预测因子

Charli E Harlow,Josan Gandawijaya,Rosemary A Bamford,Emily-Rose Martin,Andrew R Wood,Peter J van der Most,Toshiko Tanaka,Hampton L Leonard,Amy S Etheridge,Federico Innocenti,Robin N Beaumont,Jessica Tyrrell,Mike A Nalls,Eleanor M Simonsick,Pranav S Garimella,Eric J Shiroma,Niek Verweij,Peter van der Meer,Ron T Gansevoort,Harold Snieder,Paul J Gallins,Dereje D Jima,Fred Wright,Yi-Hui Zhou,Luigi Ferrucci,Stefania Bandinelli,Dena G Hernandez,Pim van der Harst,Vickas V Patel,Dawn M Waterworth,Audrey Y Chu,Asami Oguro-Ando,Timothy M Frayling

Prosaposin is a regulator of progranulin levels and oligomerization

Prosaposin 是前颗粒蛋白水平和寡聚化的调节剂

Alexandra M Nicholson, NiCole A Finch, Marcio Almeida, Ralph B Perkerson, Marka van Blitterswijk, Aleksandra Wojtas, Basar Cenik, Sergio Rotondo, Venette Inskeep, Laura Almasy, Thomas Dyer, Juan Peralta, Goo Jun, Andrew R Wood, Timothy M Frayling, Christian Fuchsberger, Sharon Fowler, Tanya M Teslov

Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus

综合遗传和表观遗传分析确定了 FTO 2 型糖尿病和肥胖易感基因位点的单倍型特异性甲基化

Christopher G Bell, Sarah Finer, Cecilia M Lindgren, Gareth A Wilson, Vardhman K Rakyan, Andrew E Teschendorff, Pelin Akan, Elia Stupka, Thomas A Down, Inga Prokopenko, Ian M Morison, Jonathan Mill, Ruth Pidsley; International Type 2 Diabetes 1q Consortium; Panos Deloukas, Timothy M Frayling, Andrew