日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Whole-genome sequencing analysis of anthropometric traits in 672,976 individuals reveals convergence between rare and common genetic associations

对 672,976 名个体的全基因组测序分析显示,人体测量特征存在罕见和常见遗传关联,并揭示了二者之间的趋同性。

Hawkes, Gareth; Wright, Harrison I W; Beaumont, Robin N; Chundru, Kartik; Hanson, Aimee; Jackson, Leigh; Murray, Anna; Patel, Kashyap; Frayling, Timothy M; Wright, Caroline F; Wood, Andrew R; Weedon, Michael N

Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height

对 333,100 名个体进行全基因组测序,揭示了罕见的非编码单变异和与身高相关的聚集性变异

Hawkes, Gareth; Beaumont, Robin N; Li, Zilin; Mandla, Ravi; Li, Xihao; Albert, Christine M; Arnett, Donna K; Ashley-Koch, Allison E; Ashrani, Aneel A; Barnes, Kathleen C; Boerwinkle, Eric; Brody, Jennifer A; Carson, April P; Chami, Nathalie; Chen, Yii-Der Ida; Chung, Mina K; Curran, Joanne E; Darbar, Dawood; Ellinor, Patrick T; Fornage, Myrian; Gordeuk, Victor R; Guo, Xiuqing; He, Jiang; Hwu, Chii-Min; Kalyani, Rita R; Kaplan, Robert; Kardia, Sharon L R; Kooperberg, Charles; Loos, Ruth J F; Lubitz, Steven A; Minster, Ryan L; Naseri, Take; Viali, Satupa'itea; Mitchell, Braxton D; Murabito, Joanne M; Palmer, Nicholette D; Psaty, Bruce M; Redline, Susan; Shoemaker, M Benjamin; Silverman, Edwin K; Telen, Marilyn J; Weiss, Scott T; Yanek, Lisa R; Zhou, Hufeng; Liu, Ching-Ti; North, Kari E; Justice, Anne E; Locke, Jonathan M; Owens, Nick; Murray, Anna; Patel, Kashyap; Frayling, Timothy M; Wright, Caroline F; Wood, Andrew R; Lin, Xihong; Manning, Alisa; Weedon, Michael N

PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice

周期性关节负荷前进行 PTH 治疗可改善小鼠软骨健康并减轻负荷诱发的骨关节炎发展

Adrien Y Antoinette, Sophia N Ziemian, Allison R Brown, Erin B Hudson, Carolyn Chlebek, Timothy M Wright, Steven R Goldring, Mary B Goldring, Miguel Otero, Marjolein C H van der Meulen

The role of accelerometer-derived sleep traits on glycated haemoglobin and glucose levels: a Mendelian randomization study

加速度计衍生的睡眠特征对糖化血红蛋白和血糖水平的影响:一项孟德尔随机化研究

Liu, Junxi; Richmond, Rebecca C; Anderson, Emma L; Bowden, Jack; Barry, Ciarrah-Jane S; Dashti, Hassan S; Daghlas, Iyas S; Lane, Jacqueline M; Kyle, Simon D; Vetter, Céline; Morrison, Claire L; Jones, Samuel E; Wood, Andrew R; Frayling, Timothy M; Wright, Alison K; Carr, Matthew J; Anderson, Simon G; Emsley, Richard A; Ray, David W; Weedon, Michael N; Saxena, Richa; Rutter, Martin K; Lawlor, Deborah A

Collagen XI mutation lowers susceptibility to load-induced cartilage damage in mice

胶原蛋白 XI 突变降低小鼠对负荷诱发软骨损伤的敏感性

Derek T Holyoak, Miguel Otero, Naa Shidaa Armar, Sophia N Ziemian, Ariana Otto, Devinne Cullinane, Timothy M Wright, Steven R Goldring, Mary B Goldring, Marjolein C H van der Meulen

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

高通量表型筛选确定氯法齐明是治疗隐孢子虫病的潜在药物

Melissa S Love, Federico C Beasley, Rajiv S Jumani, Timothy M Wright, Arnab K Chatterjee, Christopher D Huston, Peter G Schultz, Case W McNamara

Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody-drug Conjugate

通过抗体-药物偶联物将抗炎PDE4抑制剂靶向递送至免疫细胞

Shan Yu ,Aaron D Pearson ,Reyna Kv Lim ,David T Rodgers ,Sijia Li ,Holly B Parker ,Meredith Weglarz ,Eric N Hampton ,Michael J Bollong ,Jiayin Shen ,Claudio Zambaldo ,Danling Wang ,Ashley K Woods ,Timothy M Wright ,Peter G Schultz ,Stephanie A Kazane ,Travis S Young ,Matthew S Tremblay

Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant

Kv1.3 通道阻断抗体作为选择性免疫抑制剂的合理设计

Rongsheng E Wang, Ying Wang, Yuhan Zhang, Chase Gabrelow, Yong Zhang, Victor Chi, Qiangwei Fu, Xiaozhou Luo, Danling Wang, Sean Joseph, Kristen Johnson, Arnab K Chatterjee, Timothy M Wright, Vân T B Nguyen-Tran, John Teijaro, Argyrios N Theofilopoulos, Peter G Schultz, Feng Wang

Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

针对 B 细胞恶性肿瘤的 CAR-T 细胞开关介导激活和重新靶向

David T Rodgers, Magdalena Mazagova, Eric N Hampton, Yu Cao, Nitya S Ramadoss, Ian R Hardy, Andrew Schulman, Juanjuan Du, Feng Wang, Oded Singer, Jennifer Ma, Vanessa Nunez, Jiayin Shen, Ashley K Woods, Timothy M Wright, Peter G Schultz, Chan Hyuk Kim, Travis S Young

Versatile strategy for controlling the specificity and activity of engineered T cells

控制工程 T 细胞特异性和活性的多功能策略

Jennifer S Y Ma, Ji Young Kim, Stephanie A Kazane, Sei-Hyun Choi, Hwa Young Yun, Min Soo Kim, David T Rodgers, Holly M Pugh, Oded Singer, Sophie B Sun, Bryan R Fonslow, James N Kochenderfer, Timothy M Wright, Peter G Schultz, Travis S Young, Chan Hyuk Kim, Yu Cao