日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering

用于多重基因组编辑、疾病建模和免疫细胞工程的Cas12a敲入小鼠

Kaiyuan Tang #   ,Liqun Zhou #   ,Xiaolong Tian ,Shao-Yu Fang,Erica Vandenbulcke ,Andrew Du ,Johanna Shen ,Hanbing Cao,Jerry Zhou ,Krista Chen ,Hyunu R Kim,Zhicheng Luo ,Shan Xin,Shawn H Lin   ,Daniel Park ,Luojia Yang   ,Yueqi Zhang,Kazushi Suzuki,Medha Majety ,Xinyu Ling,Stanley Z Lam ,Ryan D Chow ,Ping Ren,Bo Tao ,Keyi Li,Adan Codina   ,Xiaoyun Dai ,Xingbo Shang ,Suxia Bai,Timothy Nottoli,Andre Levchenko   ,Carmen J Booth,Chen Liu,Rong Fan       ,Matthew B Dong   ,Xiaoyu Zhou  ,Sidi Chen

Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis

组织力学稳态中通过 talin 1 感知细胞刚度

Manasa Chanduri,Abhishek Kumar,Dar Weiss,Nir Emuna,Igor Barsukov,Miusi Shi,Keiichiro Tanaka,Xinzhe Wang,Amit Datye,Jean Kanyo,Florine Collin,TuKiet Lam,Udo D Schwarz,Suxia Bai,Timothy Nottoli,Benjamin T Goult,Jay D Humphrey,Martin A Schwartz      0

Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

神经发育障碍相关 TRIO 变异的杂合性导致小鼠的行为、神经元发育和突触传递出现明显缺陷

Yevheniia Ishchenko, Amanda T Jeng, Shufang Feng, Timothy Nottoli, Cindy Manriquez-Rodriguez, Khanh K Nguyen, Melissa G Carrizales, Matthew J Vitarelli, Ellen E Corcoran, Charles A Greer, Samuel A Myers, Anthony J Koleske

Cell type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development

小鼠皮质发育过程中由于 Chd8 单倍体不足导致细胞类型特异性基因表达失调

Kristina M Yim, Marybeth Baumgartner, Martina Krenzer, María F Rosales Larios, Guillermina Hill-Terán, Timothy Nottoli, Rebecca A Muhle, James P Noonan

Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations

大脑大静脉畸形中脑血管发育关键信号调节因子的突变

Shujuan Zhao # ,Kedous Y Mekbib # ,Martijn A van der Ent # ,Garrett Allington # ,Andrew Prendergast ,Jocelyn E Chau ,Hannah Smith ,John Shohfi ,Jack Ocken ,Daniel Duran ,Charuta G Furey ,Le Thi Hao ,Phan Q Duy ,Benjamin C Reeves ,Junhui Zhang ,Carol Nelson-Williams ,Di Chen ,Boyang Li ,Timothy Nottoli ,Suxia Bai ,Myron Rolle ,Xue Zeng ,Weilai Dong ,Po-Ying Fu ,Yung-Chun Wang ,Shrikant Mane ,Paulina Piwowarczyk ,Katie Pricola Fehnel ,Alfred Pokmeng See ,Bermans J Iskandar ,Beverly Aagaard-Kienitz ,Quentin J Moyer ,Evan Dennis ,Emre Kiziltug ,Adam J Kundishora ,Tyrone DeSpenza Jr ,Ana B W Greenberg ,Seblewengel M Kidanemariam ,Andrew T Hale ,James M Johnston ,Eric M Jackson ,Phillip B Storm ,Shih-Shan Lang ,William E Butler ,Bob S Carter ,Paul Chapman ,Christopher J Stapleton ,Aman B Patel ,Georges Rodesch ,Stanislas Smajda ,Alejandro Berenstein ,Tanyeri Barak ,E Zeynep Erson-Omay ,Hongyu Zhao ,Andres Moreno-De-Luca ,Mark R Proctor ,Edward R Smith ,Darren B Orbach ,Seth L Alper ,Stefania Nicoli ,Titus J Boggon ,Richard P Lifton ,Murat Gunel ,Philip D King ,Sheng Chih Jin ,Kristopher T Kahle

Isradipine therapy in Cacna1dIle772Met/+ mice ameliorates primary aldosteronism and neurologic abnormalities

Cacna1dIle772Met/+ 小鼠接受伊拉地平治疗可改善原发性醛固酮增多症和神经系统异常

Gabriel Stölting, Hoang An Dinh, Marina Volkert, Nicole Hellmig, Julia Schewe, Luise Hennicke, Eric Seidel, Herbert Oberacher, Junhui Zhang, Richard P Lifton, Iris Urban, Melissa Long, Marion Rivalan, Timothy Nottoli, Ute I Scholl

Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations

盖伦静脉畸形中内皮细胞 Ras 信号网络的遗传失调

Shujuan Zhao, Kedous Y Mekbib, Martijn A van der Ent, Garrett Allington, Andrew Prendergast, Jocelyn E Chau, Hannah Smith, John Shohfi, Jack Ocken, Daniel Duran, Charuta G Furey, Hao Thi Le, Phan Q Duy, Benjamin C Reeves, Junhui Zhang, Carol Nelson-Williams, Di Chen, Boyang Li, Timothy Nottoli, Suxi

Modeling uniquely human gene regulatory function via targeted humanization of the mouse genome

通过小鼠基因组的靶向人源化模拟独特的人类基因调控功能

Emily V Dutrow, Deena Emera, Kristina Yim, Severin Uebbing, Acadia A Kocher, Martina Krenzer, Timothy Nottoli, Daniel B Burkhardt, Smita Krishnaswamy, Angeliki Louvi, James P Noonan3

Loss of Serum Glucocorticoid-Inducible Kinase 1 SGK1 Worsens Malabsorption and Diarrhea in Microvillus Inclusion Disease (MVID)

血清糖皮质激素诱导激酶 1 SGK1 的缺失加剧了微绒毛包涵体病 (MVID) 中的吸收不良和腹泻症状

Md Kaimul Ahsan, Diego Carlos Dos Reis, Andrea Barbieri, Kaelyn D Sumigray, Timothy Nottoli, Pedro J Salas, Nadia A Ameen

A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus-like Disease in Mice

与系统性红斑狼疮相关的人类MSH6种系变异可诱发小鼠出现类似狼疮的疾病

Rithy Meas ,Joanne Nititham ,Kimberly E Taylor ,Stephen Maher ,Kaylyn Clairmont ,Kelly E W Carufe ,Michael Kashgarian ,Timothy Nottoli ,Ana Cheong ,Zachary D Nagel ,Patrick M Gaffney ,Lindsey A Criswell ,Joann B Sweasy