日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRAS Inhibition Activates an Actionable CD24 "Do Not Eat Me" Signal in Pancreatic Cancer

KRAS抑制激活胰腺癌中可发挥作用的CD24“别吃我”信号

Yongkun Wei ,Minghui Liu # ,Er-Yen Yen # ,Jun Yao # ,Zhenzhen Xun ,Phuoc T Nguyen ,Xiaofei Wang ,Zecheng Yang ,Abdelrahman Yousef ,Dean Pan ,Yanqing Jin ,Ching-Fei Li ,Madelaine S Theardy ,Jangho Park ,Yiming Cai ,Mitsunobu Takeda ,Matthew Vasquez ,Elizabeth M Park ,David H Peng ,Yong Zhou ,Hong Zhao ,Timothy P Heffernan ,Andrea Viale ,Huamin Wang ,Stephanie S Watowich ,Han Liang ,Dan Zhao ,Ronald A DePinho ,Wantong Yao ,Haoqiang Ying

KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

KRASG12D抑制可重编程早期和晚期胰腺癌的微环境,从而促进CD8+ T细胞介导的FAS杀伤作用

Krishnan K Mahadevan ,Kathleen M McAndrews ,Valerie S LeBleu ,Sujuan Yang ,Hengyu Lyu ,Bingrui Li ,Amari M Sockwell ,Michelle L Kirtley ,Sami J Morse ,Barbara A Moreno Diaz ,Michael P Kim ,Ningping Feng ,Anastasia M Lopez ,Paola A Guerrero ,Francesca Paradiso ,Hikaru Sugimoto ,Kent A Arian ,Haoqiang Ying ,Yasaman Barekatain ,Lakshmi Kavitha Sthanam ,Patience J Kelly ,Anirban Maitra ,Timothy P Heffernan ,Raghu Kalluri

Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy

Neddylation 抑制使肾髓质癌肿瘤对铂类化疗敏感

Daniel D Shapiro, Niki Millward Zacharias, Durga N Tripathi, Menuka Karki, Jean-Philippe Bertocchio, Melinda Soeung, Rong He, Mary E Westerman, Jianjun Gao, Priya Rao, Truong N A Lam, Eric Jonasch, Luigi Perelli, Emily H Cheng, Alessandro Carugo, Timothy P Heffernan, Cheryl L Walker, Giannicola Geno

Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis

致癌基因 KRAS 通过突变 p53 募集广泛的转录网络,从而驱动胰腺癌转移

Michael P Kim, Xinqun Li, Jenying Deng, Yun Zhang, Bingbing Dai, Kendra L Allton, Tara G Hughes, Christian Siangco, Jithesh J Augustine, Ya'an Kang, Joy M McDaniel, Shunbin Xiong, Eugene J Koay, Florencia McAllister, Christopher A Bristow, Timothy P Heffernan, Anirban Maitra, Bin Liu, Michelle C Bar

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

PRMT1依赖的RNA代谢和DNA损伤反应调控维持胰腺导管腺癌

Virginia Giuliani,Meredith A Miller #,Chiu-Yi Liu #,Stella R Hartono #,Caleb A Class,Christopher A Bristow,Erika Suzuki,Lionel A Sanz,Guang Gao,Jason P Gay,Ningping Feng,Johnathon L Rose,Hideo Tomihara,Joseph R Daniele,Michael D Peoples,Jennifer P Bardenhagen,Mary K Geck Do,Qing E Chang,Bhavatarini Vangamudi,Christopher Vellano,Haoqiang Ying,Angela K Deem,Kim-Anh Do,Giannicola Genovese,Joseph R Marszalek,Jeffrey J Kovacs,Michael Kim,Jason B Fleming,Ernesto Guccione,Andrea Viale,Anirban Maitra,M Emilia Di Francesco,Timothy A Yap,Philip Jones,Giulio Draetta,Alessandro Carugo,Frederic Chedin,Timothy P Heffernan

The cytosolic iron-sulfur cluster assembly (CIA) pathway is required for replication stress tolerance of cancer cells to Chk1 and ATR inhibitors

细胞质铁硫簇组装 (CIA) 途径是癌细胞对 Chk1 和 ATR 抑制剂的复制应激耐受性所必需的

Abena B Redwood, Xiaomei Zhang, Sahil B Seth, Zhongqi Ge, Wendy E Bindeman, Xinhui Zhou, Vidya C Sinha, Timothy P Heffernan, Helen Piwnica-Worms

Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints

通过废除细胞周期检查点来靶向头颈癌中的 DNA 损伤反应

Jessica M Molkentine, David P Molkentine, Kathleen A Bridges, Tongxin Xie, Liangpeng Yang, Aakash Sheth, Timothy P Heffernan, David A Clump, Alma Z Faust, Robert L Ferris, Jeffrey N Myers, Mitchell J Frederick, Kathryn A Mason, Raymond E Meyn, Curtis R Pickering, Heath D Skinner

Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

全面的分子特征分析揭示了肾髓质癌独特的基因组和免疫学特征

Pavlos Msaouel ,Gabriel G Malouf ,Xiaoping Su ,Hui Yao ,Durga N Tripathi ,Melinda Soeung ,Jianjun Gao ,Priya Rao ,Cristian Coarfa ,Chad J Creighton ,Jean-Philippe Bertocchio ,Selvi Kunnimalaiyaan ,Asha S Multani ,Jorge Blando ,Rong He ,Daniel D Shapiro ,Luigi Perelli ,Sanjana Srinivasan ,Federica Carbone ,Patrick G Pilié ,Menuka Karki ,Riyad N H Seervai ,Bujamin H Vokshi ,Dolores Lopez-Terrada ,Emily H Cheng ,Ximing Tang ,Wei Lu ,Ignacio I Wistuba ,Timothy C Thompson ,Irwin Davidson ,Virginia Giuliani ,Katharina Schlacher ,Alessandro Carugo ,Timothy P Heffernan ,Padmanee Sharma ,Jose A Karam ,Christopher G Wood ,Cheryl L Walker ,Giannicola Genovese ,Nizar M Tannir

Pharmacologic profiling of patient-derived xenograft models of primary treatment-naïve triple-negative breast cancer

对未经治疗的原发性三阴性乳腺癌患者来源异种移植模型进行药理学分析

Reid T Powell ,Abena Redwood ,Xuan Liu ,Lei Guo ,Shirong Cai ,Xinhui Zhou ,Yizheng Tu ,Xiaomei Zhang ,Yuan Qi ,Yan Jiang ,Gloria Echeverria ,Ningping Feng ,XiaoYan Ma ,Virginia Giuliani ,Joseph R Marszalek ,Timothy P Heffernan ,Christopher P Vellano ,Jason B White ,Clifford Stephan ,Peter J Davies ,Stacy Moulder ,W Fraser Symmans ,Jeffrey T Chang ,Helen Piwnica-Worms

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

Syndecan 1 是胰腺癌中巨胞饮作用的关键介质

Wantong Yao ,Johnathon L Rose ,Wei Wang ,Sahil Seth ,Hong Jiang ,Ayumu Taguchi ,Jintan Liu ,Liang Yan ,Avnish Kapoor ,Pingping Hou ,Ziheng Chen ,Qiuyun Wang ,Luigi Nezi ,Zhaohui Xu ,Jun Yao ,Baoli Hu ,Piergiorgio F Pettazzoni ,I Lin Ho ,Ningping Feng ,Vandhana Ramamoorthy ,Shan Jiang ,Pingna Deng ,Grace J Ma ,Peter Den ,Zhi Tan ,Shu Xing Zhang ,Huamin Wang ,Y Alan Wang ,Angela K Deem ,Jason B Fleming ,Alessandro Carugo ,Timothy P Heffernan ,Anirban Maitra ,Andrea Viale ,Haoqiang Ying ,Samir Hanash ,Ronald A DePinho ,Giulio F Draetta