日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ADAR and hnRNPC deficiency synergize in activating endogenous dsRNA-induced type I IFN responses

ADAR 和 hnRNPC 缺乏可协同激活内源性 dsRNA 诱导的 I 型 IFN 反应

Anna-Maria Herzner, Zia Khan, Eric L Van Nostrand, Sara Chan, Trinna Cuellar, Ronald Chen, Ximo Pechuan-Jorge, Laszlo Komuves, Margaret Solon, Zora Modrusan, Benjamin Haley, Gene W Yeo, Timothy W Behrens, Matthew L Albert

LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation

LACC1 在小鼠关节炎和炎症模型中调节 TNF 和 IL-17

Cara Skon-Hegg, Juan Zhang, Xiumin Wu, Meredith Sagolla, Naruhisa Ota, Arthur Wuster, Jennifer Tom, Emma Doran, Nandhini Ramamoorthi, Patrick Caplazi, John Monroe, Wyne P Lee, Timothy W Behrens

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

配对免疫球蛋白样 2 型受体 Alpha G78R 变体可改变配体结合并对阿尔茨海默病提供保护

Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graham

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice

Ox40/Ox40配体通路促进NZB/W F1小鼠的致病性Th细胞反应、浆母细胞积累和狼疮性肾炎

Jonathan Sitrin ,Eric Suto ,Arthur Wuster ,Jeffrey Eastham-Anderson ,Jeong M Kim ,Cary D Austin ,Wyne P Lee ,Timothy W Behrens

A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains

IL-6R 的一种常见变体与阿尔茨海默病患者大脑中 IL-6 通路活性升高有关

Patrick C G Haddick ,Jessica L Larson ,Nisha Rathore ,Tushar R Bhangale ,Qui T Phung ,Karpagam Srinivasan ,David V Hansen ,Jennie R Lill ,Jonathan Haines ,Lindsay A Farrer ,John S Kauwe ,Gerard D Schellenberg ,Carlos Cruchaga ,Alison M Goate ,Timothy W Behrens ,Ryan J Watts ,Robert R Graham ,Joshua S Kaminker ,Marcel van der Brug

RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency

两名兄弟姐妹均出现 RAC2 功能丧失突变,且具有常见变异性免疫缺陷的特征

Omar K Alkhairy, Nima Rezaei, Robert R Graham, Hassan Abolhassani, Stephan Borte, Kjell Hultenby, Chenglin Wu, Asghar Aghamohammadi, David A Williams, Timothy W Behrens, Lennart Hammarström, Qiang Pan-Hammarström

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

CSK调控多态性与系统性红斑狼疮相关,并影响B细胞信号传导和活化。

Nataly Manjarrez-Orduño ,Emiliano Marasco, Sharon A Chung, Matthew S Katz, Jenna F Kiridly, Kim R Simpfendorfer, Jan Freudenberg, David H Ballard, Emil Nashi, Thomas J Hopkins, Deborah S Cunninghame Graham, Annette T Lee, Marieke J H Coenen, Barbara Franke, Dorine W Swinkels, Robert R Graham, Robert P Kimberly, Patrick M Gaffney, Timothy J Vyse, Timothy W Behrens, Lindsey A Criswell, Betty Diamond, Peter K Gregersen

Association of endogenous anti-interferon-α autoantibodies with decreased interferon-pathway and disease activity in patients with systemic lupus erythematosus

系统性红斑狼疮患者内源性抗干扰素-α自身抗体与干扰素通路减少及疾病活动性的关系

Alyssa M Morimoto, Donna Thibault Flesher, Jihong Yang, Kristen Wolslegel, Xiangdan Wang, Ann Brady, Alexander R Abbas, Valerie Quarmby, Eric Wakshull, Bruce Richardson, Michael J Townsend, Timothy W Behrens

Functional studies on the IBD susceptibility gene IL23R implicate reduced receptor function in the protective genetic variant R381Q

IBD 易感基因 IL23R 的功能研究表明,保护性遗传变异 R381Q 导致受体功能降低

Svetlana Pidasheva, Sara Trifari, Anne Phillips, Jason A Hackney, Yan Ma, Ashley Smith, Sue J Sohn, Hergen Spits, Randall D Little, Timothy W Behrens, Lee Honigberg, Nico Ghilardi, Hilary F Clark

Systematic comparison of gene expression between murine memory and naive B cells demonstrates that memory B cells have unique signaling capabilities

小鼠记忆 B 细胞和幼稚 B 细胞基因表达的系统比较表明,记忆 B 细胞具有独特的信号传导能力

Mary M Tomayko, Shannon M Anderson, Catherine E Brayton, Saheli Sadanand, Natalie C Steinel, Timothy W Behrens, Mark J Shlomchik