日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors

发现一种小分子抑制剂,该抑制剂能将Polθ捕获在DNA上,并与PARP抑制剂产生协同作用。

William Fried # ,Mrityunjay Tyagi # ,Leonid Minakhin ,Gurushankar Chandramouly ,Taylor Tredinnick ,Mercy Ramanjulu ,William Auerbacher ,Marissa Calbert ,Timur Rusanov ,Trung Hoang ,Nikita Borisonnik ,Robert Betsch ,John J Krais ,Yifan Wang ,Umeshkumar M Vekariya ,John Gordon ,George Morton ,Tatiana Kent ,Tomasz Skorski ,Neil Johnson ,Wayne Childers ,Xiaojiang S Chen ,Richard T Pomerantz

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

非光敏性毛发硫营养不良症中,套索脱支酶与内含子结合复合物之间的功能联系存在缺陷。

Brittany A Townley ,Luke Buerer ,Ning Tsao ,Albino Bacolla ,Fadhel Mansoori ,Timur Rusanov ,Nathanial Clark ,Negar Goodarzi ,Nicolas Schmidt ,Sridhar Nonavinkere Srivatsan ,Hua Sun ,Reilly A Sample ,Joshua R Brickner ,Drew McDonald ,Miaw-Sheue Tsai ,Matthew J Walter ,David F Wozniak ,Alex S Holehouse ,Vladimir Pena ,John A Tainer ,William G Fairbrother ,Nima Mosammaparast

Polθ reverse transcribes RNA and promotes RNA-templated DNA repair

Polθ 逆转录 RNA 并促进 RNA 模板 DNA 修复

Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba A Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M Stark, Xiaojiang S C

Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining

Polθ通过微同源介导的末端连接促进5’-DNA-蛋白质交联的修复

Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T Pomerantz