日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Implementing a rapid analysis framework to evaluate wellness initiatives in Massachusetts federally qualified health centers

实施快速分析框架,以评估马萨诸塞州联邦认证医疗中心的健康促进计划

Miranda, Isabelle; Lopes, Maria; Banister, Gaurdia; Finley, Watura; Sylvia, Louisa G; Jones, Dorothy A; Carrington, Scune; Feldpausch, Meghan N; Pannell, Madeleine; Fioroni, Tinamarie; Park, Elyse R

In vivo biodistribution and pharmacokinetics of sotrovimab, a SARS-CoV-2 monoclonal antibody, in healthy cynomolgus monkeys

SARS-CoV-2单克隆抗体sotrovimab在健康食蟹猴体内的体内生物分布和药代动力学

Aweda, Tolulope A; Cheng, Shih-Hsun; Lenhard, Stephen C; Sepp, Armin; Skedzielewski, Tinamarie; Hsu, Chih-Yang; Marshall, Shelly; Haag, Heather; Kehler, Jonathan; Jagdale, Prabhas; Peter, Alessia; Schmid, Michael A; Gehman, Andrew; Doan, Minh; Mayer, Andrew P; Gorycki, Peter; Fanget, Marie; Colas, Christophe; Smith, Brenda; Maier, Curtis C; Alsaid, Hasan

Immuno-PET Monitoring of CD8(+) T Cell Infiltration Post ICOS Agonist Antibody Treatment Alone and in Combination with PD-1 Blocking Antibody Using a (89)Zr Anti-CD8(+) Mouse Minibody in EMT6 Syngeneic Tumor Mouse

在EMT6同源肿瘤小鼠模型中,使用(89)Zr抗CD8(+)小鼠微型抗体,通过免疫PET监测ICOS激动剂抗体单独治疗以及与PD-1阻断抗体联合治疗后CD8(+) T细胞的浸润情况。

Alsaid, Hasan; Cheng, Shih-Hsun; Bi, Meixia; Xie, Fang; Rambo, Mary; Skedzielewski, Tinamarie; Hoang, Bao; Mohanan, Sunish; Comroe, Debra; Gehman, Andrew; Hsu, Chih-Yang; Farhangi, Kamyar; Tran, Hoang; Sherina, Valeriia; Doan, Minh; Groseclose, M Reid; Hopson, Christopher B; Brett, Sara; Wilson, Ian A; Nicholls, Andrew; Ballas, Marc; Waight, Jeremy D; Jucker, Beat M

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

pH 响应性纳米粒子靶向内体中的神经激肽 1 受体以预防慢性疼痛

Paulina D Ramírez-García, Jeffri S Retamal, Priyank Shenoy, Wendy Imlach, Matthew Sykes, Nghia Truong, Luis Constandil, Teresa Pelissier, Cameron J Nowell, Song Y Khor, Louis M Layani, Chris Lumb, Daniel P Poole, TinaMarie Lieu, Gregory D Stewart, Quynh N Mai, Dane D Jensen, Rocco Latorre, Nicole N

Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity

结肠支配传入神经上的致痒因子TGR5、MrgprA3和MrgprC11的激活可诱发内脏高敏感性。

Castro, Joel; Harrington, Andrea M; Lieu, TinaMarie; Garcia-Caraballo, Sonia; Maddern, Jessica; Schober, Gudrun; O'Donnell, Tracey; Grundy, Luke; Lumsden, Amanda L; Miller, Paul; Ghetti, Andre; Steinhoff, Martin S; Poole, Daniel P; Dong, Xinzhong; Chang, Lin; Bunnett, Nigel W; Brierley, Stuart M

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

蛋白激酶 D 和 Gβγ 通过蛋白酶激活受体 2 的偏向激动剂介导持续的伤害性信号传导

Peishen Zhao, Luke A Pattison, Dane D Jensen, Nestor N Jimenez-Vargas, Rocco Latorre, TinaMarie Lieu, Josue O Jaramillo, Cintya Lopez-Lopez, Daniel P Poole, Stephen J Vanner, Brian L Schmidt, Nigel W Bunnett

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

神经激肽1受体在内体中的信号传导介导持续性伤害感受,是延长疼痛缓解的有效治疗靶点。

Jensen, Dane D; Lieu, TinaMarie; Halls, Michelle L; Veldhuis, Nicholas A; Imlach, Wendy L; Mai, Quynh N; Poole, Daniel P; Quach, Tim; Aurelio, Luigi; Conner, Joshua; Herenbrink, Carmen Klein; Barlow, Nicholas; Simpson, Jamie S; Scanlon, Martin J; Graham, Bimbil; McCluskey, Adam; Robinson, Phillip J; Escriou, Virginie; Nassini, Romina; Materazzi, Serena; Geppetti, Pierangelo; Hicks, Gareth A; Christie, Macdonald J; Porter, Christopher J H; Canals, Meritxell; Bunnett, Nigel W

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

降钙素基因相关肽受体的内体信号传导介导疼痛传递

Yarwood, Rebecca E; Imlach, Wendy L; Lieu, TinaMarie; Veldhuis, Nicholas A; Jensen, Dane D; Klein Herenbrink, Carmen; Aurelio, Luigi; Cai, Zhijian; Christie, MacDonald J; Poole, Daniel P; Porter, Christopher J H; McLean, Peter; Hicks, Gareth A; Geppetti, Pierangelo; Halls, Michelle L; Canals, Meritxell; Bunnett, Nigel W

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease

G-CSF受体阻断可缓解关节炎疼痛和疾病

Ming-Chin Lee ,James A McCubbin ,Anne D Christensen ,Daniel P Poole ,Pradeep Rajasekhar ,TinaMarie Lieu ,Nigel W Bunnett ,Sonia Garcia-Caraballo ,Andelain Erickson ,Stuart M Brierley ,Reem Saleh ,Adrian Achuthan ,Andrew J Fleetwood ,Robin L Anderson ,John A Hamilton ,Andrew D Cook

Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice

对 GSK2849330(一种 ADCC 和 CDC 优化的抗 HER3 mAb)的生物分布及其在人类肿瘤小鼠中肿瘤巨噬细胞募集的作用进行无创成像评估

Hasan Alsaid, Tinamarie Skedzielewski, Mary V Rambo, Kristen Hunsinger, Bao Hoang, William Fieles, Edward R Long, James Tunstead, Danielle J Vugts, Matthew Cleveland, Neil Clarke, Christopher Matheny, Beat M Jucker