日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Decoding efficacy and resistance space at a drug binding site

解码药物结合位点的疗效和耐药性空间

Altmann, Simone; Mendoza-Martinez, Cesar; Ridgway, Melanie; Tinti, Michele; Saini, Jagmohan S; Ibrahim, Peter E G F; Thomas, Michael; De Rycker, Manu; Bodkin, Michael J; Horn, David

Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3

锥虫布氏锥虫CPSF3中与阿可唑硼罗耐药性相关的突变

Ridgway, Melanie; Novotná, Markéta; Mendoza-Martinez, Cesar; Tinti, Michele; Altmann, Simone; Sloan, Graeme; Horn, David

Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes

锥虫动质体丢失的遗传起源和蛋白质组学后果

Ridgway, Melanie; Escrivani, Douglas O; Novotná, Markéta; Wood, Amy; Tinti, Michele; Schnaufer, Achim; Horn, David

Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas' disease drug discovery

在恰加斯病药物研发过程中,利用非靶向代谢组学对细胞色素b抑制剂进行筛选

MacLeod, A Kenneth; Tulloch, Lindsay B; Tinti, Michele; Edwards, Darren; Wyllie, Susan; Read, Kevin D

Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

精确编辑的组蛋白尾部会破坏锥虫中的多顺反子基因表达调控

Novotná, Markéta; Tinti, Michele; Faria, Joana R C; Horn, David

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease

靶向赖氨酰tRNA合成酶的抗锥虫喹唑啉类药物在急性恰加斯病小鼠模型中显示出部分疗效。

Tulloch, Lindsay B; Tawell, Hugh; Taylor, Annie E; Lima, Marta Lopes; Dawson, Alice; Carvalho, Sandra; Wall, Richard J; Corpas-Lopez, Victoriano; Dey, Gourav; Duggan, Jack; Magalhaes, Luma Godoy; Torrie, Leah S; Frame, Laura; Robinson, David; Patterson, Stephen; Tinti, Michele; Weaver, George W; Robinson, William J; Cal, Monica; Kaiser, Marcel; Mäser, Pascal; Sjö, Peter; Perry, Benjamin; Kelly, John M; Francisco, Amanda Fortes; Bhambra, Avninder S; Wyllie, Susan

A non-coding role for trypanosome VSG transcripts in allelic exclusion

锥虫VSG转录本在等位基因排斥中发挥非编码作用

Escrivani, Douglas O; Hutchinson, Sebastian; Tinti, Michele; Wright, Jane E; Marques, Catarina A; Faria, Joana R C; Trenaman, Anna; Horn, David

Cryptosporidium oocyst wall proteins are true components of the oocyst wall and COWP8 is not required for parasite transmission.

隐孢子虫卵囊壁蛋白是卵囊壁的真正组成部分,COWP8 不是寄生虫传播所必需的。

Bacchetti Ross, Stevens Sarah, Lemgruber Leandro, Gonzalez Oliva Mariana Azevedo, Sands Emma M, Alexandrou Konstantinos, Tinti Michele, Robinson Lee, Hanna Jack C, Seizova Simona, Goddard Peyton, Vassalli Massimo, Pawlowic Mattie Christine

A high-throughput protein tagging toolkit that retains endogenous untranslated regions for studying gene regulation in kinetoplastids

一种高通量蛋白质标记工具包,可保留内源性非翻译区,用于研究动质体中的基因调控

Carbajo, Carla Gilabert; Han, Xiaoyang; Savur, Bhairavi; Upadhyaya, Arushi; Taha, Fatima; Tinti, Michele; Wheeler, Richard J; Yates, Phillip A; Tiengwe, Calvin

A high-throughput protein tagging toolkit that retains endogenous UTRs for studying gene regulation in Kinetoplastids

一种保留内源性UTR的高通量蛋白质标记工具包,用于研究动质体中的基因调控

Carbajo, Carla Gilabert; Han, Xiaoyang; Savur, Bhairavi; Upadhyaya, Arushi; Taha, Fatima; Tinti, Michele; Wheeler, Richard J; Yates, Phillip A; Tiengwe, Calvin