日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A single dose of a CD137 antibody-drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD

单剂量CD137抗体药物偶联物可保护恒河猴同种异体造血干细胞移植受者免受急性移植物抗宿主病(GVHD)的侵害。

Gerdemann, Ulrike; Kimler, Kyle; Warren, Matthew R; McGuckin, Connor; Fleming, Ryan A; D'Ambra, Matthew R; Eran, Alal; Albanese, Alexandre; Chen, Edward; Winschel, Marlana; Cagnin, Lorenzo; Lane, Jennifer; Gorfinkel, Lev; Adams, Bartley; Kwun, Jean; Lanieri, Leanne; Hoban, Megan; Lamothe, Tahirih L; Hyzy, Sharon; Olson, Lisa M; Panoskaltsis-Mortari, Angela; Prockop, Susan E; Blazar, Bruce R; Kean, Leslie S; Tkachev, Victor

Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease

器官特异性微环境驱动急性移植物抗宿主病中T细胞的分化进化

Omdahl, Kayleigh Ingersoll; Bermea, Rene S; Fleming, Ryan; Kimler, Kyle; Kaminski, James; Hariri, Lida P; Ly, Amy; Rui, Xianliang; Cagnin, Lorenzo; Lane, Jennifer; Gerdemann, Ulrike; Blazar, Bruce R; Tkachev, Victor; Kean, Leslie S

Enhanced Costimulation Blockade With αCD154, αCD2, and αCD28 to Promote Heart Allograft Tolerance in Nonhuman Primates

利用αCD154、αCD2和αCD28增强共刺激阻断作用以促进非人灵长类动物心脏同种异体移植耐受性

Chaban, Ryan; Ileka, Ikechukwu; Kinoshita, Kohei; McGrath, Gannon; Habibabady, Zahra; Ma, Madelyn; Diaz, Victoria; Maenaka, Akihiro; Rosales, Ivy; Lederman, Seth; Tkachev, Victor; Madsen, Joren C; Pierson, Richard N 3rd

PTPN2-KO CAR-T Cells Demonstrate Enhanced Effector Function, CNS Infiltration, and Toxicity in a Non-Human Primate CAR-T Model

在非人灵长类动物CAR-T模型中,PTPN2-KO CAR-T细胞表现出增强的效应功能、中枢神经系统浸润和毒性。

Alvarez Calderon, Francesca; Fleming, Ryan A; Winschel, Marlana; Gorfinkel, Lev; Sutherland, Rebecca; Michaelis, Katherine; Kaminski, James; Palato, Elisa Rojas; Ingersoll, Kayleigh; Cagnin, Lorenzo; Lane, Jennifer; Tkachev, Victor; Kean, Leslie S; Gerdemann, Ulrike

Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies

对环孢素A进行精准编辑可产生对环孢素和沃克洛孢素耐药的细胞疗法

Wobma, Holly; Alvarez Calderon, Francesca; Dong, Jiayi; Omdahl, Kayleigh; Rui, Xianliang; Rojas Palato, Elisa J; Bermea, Rene S; Albanese, Alexandre; Wachter, Franziska; Winschel, Marlana; Michaelis, Katherine A; Cagnin, Lorenzo; Tkachev, Victor; Prockop, Susan E; Nigrovic, Peter A; Blazar, Bruce R; Gerdemann, Ulrike; Kean, Leslie S

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice

在经 CD45 抗体药物偶联物预处理的范可尼贫血小鼠中,同种异体移植未出现明显毒性或移植物抗宿主病 (GVHD)。

Saha, Asim; Palchaudhuri, Rahul; Lanieri, Leanne; Hyzy, Sharon; Riddle, Megan J; Panthera, Jamie; Eide, Cindy R; Tolar, Jakub; Panoskaltsis-Mortari, Angela; Gorfinkel, Lev; Tkachev, Victor; Gerdemann, Ulrike; Alvarez-Calderon, Francesca; Palato, Elisa Rojas; MacMillan, Margaret L; Wagner, John E; Kean, Leslie S; Osborn, Mark J; Kiem, Hans-Peter; Scadden, David T; Olson, Lisa M; Blazar, Bruce R

B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates

B细胞靶向CAR-T细胞疗法可激活患者和非人灵长类动物体内的CD8+细胞毒性CAR-Neg旁观者T细胞。

Kaminski, James; Fleming, Ryan A; Alvarez-Calderon, Francesca; Winschel, Marlana B; McGuckin, Connor; Ho, Emily E; Eng, Fay; Rui, Xianliang; Keskula, Paula; Cagnin, Lorenzo; Charles, Joanne; Zavistaski, Jillian; Margossian, Steven P; Kapadia, Malika A; Rottman, James B; Lane, Jennifer; Baumeister, Susanne H C; Tkachev, Victor; Shalek, Alex K; Kean, Leslie S; Gerdemann, Ulrike

Human OX40L-CAR-T(regs) target activated antigen-presenting cells and control T cell alloreactivity.

人类 OX40L-CAR-T(regs) 靶向活化的抗原呈递细胞并控制 T 细胞同种异体反应性

Rui Xianliang, Alvarez Calderon Francesca, Wobma Holly, Gerdemann Ulrike, Albanese Alexandre, Cagnin Lorenzo, McGuckin Connor, Michaelis Katherine A, Naqvi Kisa, Blazar Bruce R, Tkachev Victor, Kean Leslie S

A New Approach of Detecting ALK Fusion Oncogenes by RNA Sequencing Exon Coverage Analysis

一种利用RNA测序外显子覆盖率分析检测ALK融合癌基因的新方法

Zakharova, Galina; Suntsova, Maria; Rabushko, Elizaveta; Mohammad, Tharaa; Drobyshev, Alexey; Seryakov, Alexander; Poddubskaya, Elena; Moisseev, Alexey; Smirnova, Anastasia; Sorokin, Maxim; Tkachev, Victor; Simonov, Alexander; Guguchkin, Egor; Karpulevich, Evgeny; Buzdin, Anton

Bioinformatic and clinical experimental assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new combined and individual survival biomarkers outperforming MGMT promoter methylation

生物信息学和临床实验分析揭示了人类胶质母细胞瘤对替莫唑胺的耐药和敏感性机制,并鉴定出新的联合和个体生存生物标志物,其性能优于MGMT启动子甲基化。

Modestov, Alexander; Zolotovskaia, Marianna; Suntsova, Maria; Zakharova, Galina; Seryakov, Aleksander; Jovcevska, Ivana; Mlakar, Jernej; Poddubskaya, Elena; Moisseev, Aleksey; Vykhodtsev, Grigory; Roumiantsev, Sergey; Sorokin, Maksim; Tkachev, Victor; Simonov, Aleksander; Buzdin, Anton