日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett's Esophagus to adenocarcinoma

上皮和间质的协同变化:从巴雷特食管到腺癌进展的多尺度、多组学分析

Strasser, Michael K; Gibbs, David L; Gascard, Philippe; Bons, Joanna; Hickey, John W; Pan, Deng; Caruso, Joseph A; Wang, Xianhong; Chen-Tanyolac, Chira; Bai, Rosemary; Schürch, Christian M; Tan, Yuqi; Black, Sarah; Chu, Pauline; Ozkan, Alican; Basisty, Nathan; Sangwan, Veena; Rose, Jacob; Shah, Samah; Burton, Jordan B; Camilleri-Broet, Sophie; Fiset, Pierre Olivier; Bertos, Nicholas; Berube, Julie; Djambazian, Haig; Li, Rui; Oikonomopoulos, Spyridon; Elliott, Daffolyn Rachael Fels; Vernovsky, Sarah; Shimshoni, Elee; Collyar, Deborah; Russell, Ann; Ragoussis, Jiannis; Stachler, Matthew D; Goldenring, James R; McDonald, Stuart A C; Ingber, Donald E; Schilling, Birgit; Nolan, Garry P; Tlsty, Thea D; Huang, Sui; Ferri, Lorenzo E

A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma

成纤维细胞中心网络驱动肺鳞状细胞癌肿瘤微环境中的冷纤维化

Miyara, Shoval; Frenkel, Shachaf; Mayo, Avi; Gascard, Philippe; Strasser, Michael; Gibbs, David; Weizman, Eviatar; Shalom, Itay Ben; Stein, Yaniv; Pan, Deng; Caruso, Joseph A; Sangwan, Veena; Bertos, Nicholas; Berube, Julie; Camilleri-Broet, Sophie; Oikonomopoulos, Spyridon; Djambazian, Haig; Umansky, Kfir Baruch; Elkahal, Jacob; Mayer, Shimrit; Fiset, Pierre-Olivier; Ragoussis, Jiannis; Adler, Miri; Tzahor, Eldad; Huang, Sui; Ferri, Lorenzo; Tlsty, Thea D; Scherz-Shouval, Ruth; Alon, Uri

Alterations of the composition and spatial organization of the microenvironment following non-dysplastic Barrett's esophagus through progression to cancer.

从非典型增生性巴雷特食管发展为癌症的过程中,微环境的组成和空间组织发生了改变。

Lin Meng-Lay, Hickey John W, Passman Adam, Carlotti Emanuela, Devkumar Shruthi, Derwa Yannick H, ChinAleong Joanne, Hackett Richard J, Evans James, Sangwan Veena, Novelli Marco R, Justo Manuel Rodriguez, Wright Nicholas A, Jansen Marnix, Underwood Tim J, Huang Sui, Gascard Philippe, McLean Mairi H, Schürch Christian M, Tlsty Thea D, Ferri Lorenzo, Nolan Garry P, McDonald Stuart A C

Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis.

成对突变检测和空间转录组学可识别决定结肠炎肿瘤结果的细胞邻域

Moutin E B, Chang L, Giavara G, Mehmed S, Colombé M, Lourenço F C, Skoufou-Papoutsaki M N, Kemp R, Gascard P, Tlsty T, Tourigny D S, Winton D J

Extracellular Matrix Orchestration of Tissue Remodeling in the Chronically Inflamed Mouse Colon

慢性炎症小鼠结肠组织重塑的细胞外基质协调

Elisa B Moutin, Joanna Bons, Giada Giavara, Filipe Lourenco, Deng Pan, Jordan B Burton, Samah Shah, Mathilde Colombé, Philippe Gascard, Thea Tlsty, Birgit Schilling, Douglas J Winton

A hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state

混合上皮-间质转化程序使基底上皮细胞能够绕过应激诱导的停滞状态,并有助于化生乳腺癌祖细胞状态

Joseph A Caruso, Chira Chen-Tanyolac, Thea D Tlsty

Higher Nodal expression is often associated with poorer survival in patients diagnosed with melanoma and treated with anti-PD1 therapy

在接受抗PD-1治疗的黑色素瘤患者中,较高的淋巴结表达通常与较差的生存率相关。

Gascard, Philippe D; Wang, Xianhong; Nosrati, Mehdi; Kim, Kevin B; Kashani-Sabet, Mohammed; Tlsty, Thea D; Leong, Stanley P; Hendrix, Mary J C

An adaptive Epithelial-Mesenchymal Transition Program Enables Basal Epithelial Cells to Bypass Stress-Induced Stasis and Contributes to Metaplastic Breast Cancer Progenitor State

适应性上皮-间质转变程序使基底上皮细胞能够绕过应激诱导的停滞并促进化生乳腺癌祖细胞状态

Joseph A Caruso, Thea D Tlsty

Antigen-Dependent Inducible T-Cell Reporter System for PET Imaging of Breast Cancer and Glioblastoma

用于乳腺癌和胶质母细胞瘤 PET 成像的抗原依赖性诱导 T 细胞报告系统

Jaehoon Shin, Matthew F L Parker, Iowis Zhu, Aryn Alanizi, Carlos I Rodriguez, Raymond Liu, Payal B Watchmaker, Mausam Kalita, Joseph Blecha, Justin Luu, Brian Wright, Suzanne E Lapi, Robert R Flavell, Hideho Okada, Thea D Tlsty, Kole T Roybal, David M Wilson

Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity

PPARγ活性的丧失是早期促肿瘤基质重编程的特征,并决定了治疗的窗口期。

Caruso, Joseph A; Wang, Xianhong; Murrow, Lyndsay M; Rodriguez, Carlos Ivan; Chen-Tanyolac, Chira; Vu, Lisa; Chen, Yunn-Yi; Gascard, Philippe; Gartner, Zev J; Kerlikowske, Karla; Tlsty, Thea D