日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality

具有两个亲电弹头的分子双螺旋结构作为一种新型药理学模式

Li, Zhengnian; Jiang, Jie; Ficarro, Scott B; Beyett, Tyler S; To, Ciric; Tavares, Isidoro; Zhu, Yingde; Li, Jiaqi; Eck, Michael J; Jänne, Pasi A; Marto, Jarrod A; Zhang, Tinghu; Che, Jianwei; Gray, Nathanael S

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer

一种针对非小细胞肺癌中耐药突变型 EGFR 的变构抑制剂

To, Ciric; Beyett, Tyler S; Jang, Jaebong; Feng, William W; Bahcall, Magda; Haikala, Heidi M; Shin, Bo H; Heppner, David E; Rana, Jaimin K; Leeper, Brittaney A; Soroko, Kara M; Poitras, Michael J; Gokhale, Prafulla C; Kobayashi, Yoshihisa; Wahid, Kamal; Kurppa, Kari J; Gero, Thomas W; Cameron, Michael D; Ogino, Atsuko; Mushajiang, Mierzhati; Xu, Chunxiao; Zhang, Yanxi; Scott, David A; Eck, Michael J; Gray, Nathanael S; Jänne, Pasi A

Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC

喹唑啉酮类药物作为变构第四代EGFR抑制剂用于治疗非小细胞肺癌

Gero, Thomas W; Heppner, David E; Beyett, Tyler S; To, Ciric; Azevedo, Seth C; Jang, Jaebong; Bunnell, Thomas; Feru, Frederic; Li, Zhengnian; Shin, Bo Hee; Soroko, Kara M; Gokhale, Prafulla C; Gray, Nathanael S; Jänne, Pasi A; Eck, Michael J; Scott, David A

Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations

突变选择性变构EGFR降解剂对多种耐药突变有效

Jang, Jaebong; To, Ciric; De Clercq, Dries J H; Park, Eunyoung; Ponthier, Charles M; Shin, Bo Hee; Mushajiang, Mierzhati; Nowak, Radosław P; Fischer, Eric S; Eck, Michael J; Jänne, Pasi A; Gray, Nathanael S

EGFR-Mutated Lung Cancers Resistant to Osimertinib through EGFR C797S Respond to First-Generation Reversible EGFR Inhibitors but Eventually Acquire EGFR T790M/C797S in Preclinical Models and Clinical Samples

EGFR C797S 突变导致的对奥希替尼耐药的 EGFR 突变型肺癌对第一代可逆性 EGFR 抑制剂有反应,但在临床前模型和临床样本中最终会获得 EGFR T790M/C797S 突变。

Rangachari, Deepa; To, Ciric; Shpilsky, Jason E; VanderLaan, Paul A; Kobayashi, Susumu S; Mushajiang, Mierzhati; Lau, Christie J; Paweletz, Cloud P; Oxnard, Geoffrey R; Jänne, Pasi A; Costa, Daniel B

Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors

二苯并二氮杂卓酮类化合物作为变构突变选择性EGFR抑制剂的发现与优化

De Clercq, Dries J H; Heppner, David E; To, Ciric; Jang, Jaebong; Park, Eunyoung; Yun, Cai-Hong; Mushajiang, Mierzhati; Shin, Bo Hee; Gero, Thomas W; Scott, David A; Jänne, Pasi A; Eck, Michael J; Gray, Nathanael S

Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.

合成三萜类化合物靶向 Arp2/3 复合物,抑制分支肌动蛋白聚合

To Ciric, Shilton Brian H, Di Guglielmo Gianni M

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex

合成三萜类化合物2-氰基-3,12-二氧代油酸-1,9-二烯-28-酸-咪唑化物通过影响细胞骨架和极性复合物,改变转化生长因子β依赖性信号传导和细胞迁移。

To, Ciric; Kulkarni, Sarang; Pawson, Tony; Honda, Tadashi; Gribble, Gordon W; Sporn, Michael B; Wrana, Jeffrey L; Di Guglielmo, Gianni M