Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
TREM2 的缺失可以挽救小胶质细胞的过度激活,但不能挽救前粒蛋白缺乏模型中的溶酶体功能障碍和神经毒性。
期刊:EMBO Journal
影响因子:9.4
doi:10.15252/embj.2021109108
Anika Reifschneider ,Sophie Robinson ,Bettina van Lengerich ,Johannes Gnörich ,Todd Logan ,Steffanie Heindl ,Miriam A Vogt ,Endy Weidinger ,Lina Riedl ,Karin Wind ,Artem Zatcepin ,Ida Pesämaa ,Sophie Haberl ,Brigitte Nuscher ,Gernot Kleinberger ,Julien Klimmt ,Julia K Götzl ,Arthur Liesz ,Katharina Bürger ,Matthias Brendel ,Johannes Levin ,Janine Diehl-Schmid ,Jung Suh ,Gilbert Di Paolo ,Joseph W Lewcock ,Kathryn M Monroe ,Dominik Paquet ,Anja Capell ,Christian Haass