Deregulation of m6A-RNA methylation impairs adaptive hypertrophic response and drives maladaptation via mTORC1-S6K1-hyperactivation and autophagy impairment
m6A-RNA甲基化失调会损害适应性肥大反应,并通过mTORC1-S6K1过度激活和自噬功能障碍导致适应不良。
期刊:Cell Communication and Signaling
影响因子:
doi:10.1186/s12964-025-02509-0
Annamalai, Karthika; Dilliker, Soniya; Buchholz, Eric; Castro-Hernández, Ricardo; Panyam, Nikita; Pommeranz, Alessa; Wiederhake, Pascal; Wery von Limont, Nelly; Hempel, Nina; Ebner, Verena; Swarnkar, Surabhi; Mohamed, Belal A; Streckfuss-Bömeke, Katrin; Steffens, Sabine; Herzig, Stephan; Ebert, Antje; Fischer, Andre; Toischer, Karl
m6A/m5C/m7G
mTOR
表观遗传
ORC1
自噬