Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors
PP2A基因的复发性突变导致其失活,进而产生对MEK抑制剂的耐药性。
期刊:Oncogene
影响因子:6.9
doi:10.1038/s41388-019-1012-2
Caitlin M O'Connor ,Daniel Leonard ,Danica Wiredja ,Rita A Avelar ,Zhizhi Wang ,Daniela Schlatzer ,Benjamin Bryson ,Eesha Tokala ,Sarah E Taylor ,Aditya Upadhyay ,Jaya Sangodkar ,Anne-Claude Gingras ,Jukka Westermarck ,Wenqing Xu ,Analisa DiFeo ,David L Brautigan ,Shozeb Haider ,Mark Jackson ,Goutham Narla