日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Free energy perturbations in enzyme kinetic models reveal cryptic epistasis

酶动力学模型中的自由能扰动揭示了隐蔽的上位性

Buda, Karol; Tokuriki, Nobuhiko

Widespread promiscuous alkaline phosphatases underscore ancient microbial phosphite utilization

广泛存在的兼具多种底物活性的碱性磷酸酶凸显了古代微生物对亚磷酸盐的利用。

Sakuma, Morito; Konno, Naoki; Gholipour, Sevan; Chen, John Z; Tokuriki, Nobuhiko

Exploring Large Protein Sequence Space through Homology- and Representation-based Hierarchical Clustering

通过基于同源性和表征的层次聚类探索大型蛋白质序列空间

Chen, John Z; Gall, Barnabas; Pulsford, Sacha B; Tokuriki, Nobuhiko; Jackson, Colin J

Real-world efficacy of sublingual immunotherapy with Japanese cedar pollen for cypress pollinosis

日本柳杉花粉舌下免疫疗法治疗柏树花粉症的真实世界疗效

Oka, Aiko; Yamashita, Tamami; Kanai, Kengo; Yuta, Atsushi; Ogawa, Yukiko; Takahara, Eriko; Shiratsuchi, Hideki; Terada, Akihiko; Tsunoda, Takatsugu; Masuda, Takeshi; Masuno, Satoru; Kanai, Kenichi; Nagakura, Hitoshi; Tokuda, Reiko; Arao, Harumi; Bamba, Hitoshi; Yasuda, Shigenobu; Mimura, Hideya; Nakazato, Mahoko; Nakazato, Hidehisa; Houya, Noriyuki; Tsuzuki, Hideaki; Tokuriki, Masaharu; Sakaida, Mayuko; Amesara, Ryo; Ohkawa, Chikahisa; Hama, Takemitsu; Ikeda, Hiroki; Fukushima, Hisaki; Niitsu, Sumiko; Sakaguchi, Hirofumi; Iba, Norihito; Kumanomidou, Hiroshi; Hyo, Yoshiyuki; Takagi, Ryo; Koike, Takashi; Yamada, Marie; Okano, Mitsuhiro

Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamase

上位性是由于 β-内酰胺酶的酶进化过程中限速步骤的转移而产生的

Christopher Fröhlich #, H Adrian Bunzel #, Karol Buda, Adrian J Mulholland, Marc W van der Kamp, Pål J Johnsen, Hanna-Kirsti S Leiros, Nobuhiko Tokuriki

Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype

阈值样选择下的中性漂移促进了抗生素耐药表型的变异

Erdoğan, Ayşe Nisan; Dasmeh, Pouria; Socha, Raymond D; Chen, John Z; Life, Benjamin E; Jun, Rachel; Kiritchkov, Linda; Kehila, Dan; Serohijos, Adrian W R; Tokuriki, Nobuhiko

Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning

通过共同进化统计建模和深度突变扫描了解 B1 β-内酰胺酶中的上位性网络

J Z Chen, M Bisardi, D Lee, S Cotogno, F Zamponi, M Weigt, N Tokuriki

Rapid evolutionary change in trait correlations of single proteins

单个蛋白质特征相关性的快速进化变化

Pouria Dasmeh #, Jia Zheng #, Ayşe Nisan Erdoğan, Nobuhiko Tokuriki, Andreas Wagner1

Measuring differential fitness costs and interactions between genetic cassettes using fluorescent spectrophotometry

利用荧光分光光度法测量基因盒之间的差异适应性代价和相互作用

Kehila, Dan; Tokuriki, Nobuhiko

Changes in vaccine coverage and incidence of acute gastroenteritis and severe rotavirus gastroenteritis in children <5 years in Shibata City, Niigata Prefecture, Japan

日本新潟县柴田市5岁以下儿童疫苗接种率及急性肠胃炎和重症轮状病毒肠胃炎发病率的变化

Oishi, Tomohiro; Hasegawa, Satoshi; Nakano, Tokushi; Sudo, Shoji; Kuwajima, Hiroaki; Tokuriki, Shuko; Tamura, Tsutomu