日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic machine learning enables interpretable and generalizable prediction of prime editing outcomes

机制机器学习能够对主要编辑结果进行可解释且可推广的预测。

Hsu, Alvin; Chen, Peter J; Li, Angus H; Hemez, Colin F; Gao, Xin D; Terrey, Markus; Nelson, Charlie; Selvam, Vijay; Cristian, Ana; McElroy, Amber N; Steinbeck, Benjamin J; Mahadeshwar, Gandhar K; Pandey, Smriti; Barsdale, Zachary; Chen, Paul Z; Sousa, Alexander A; Sakai, Holt A; Silverstein, Rachel A; Morad, Ilias; Krueger, Ryan K; Shen, Max W; Kleinstiver, Benjamin P; Lutz, Cathleen M; Tolar, Jakub; Blazar, Bruce R; Osborn, Mark J; Liu, David R

Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

利用实验室进化的 CRISPR 相关转座酶在人类细胞中实现可编程基因插入

Witte, Isaac P; Lampe, George D; Eitzinger, Simon; Miller, Shannon M; Berríos, Kiara N; McElroy, Amber N; King, Rebeca T; Stringham, Olivia G; Gelsinger, Diego R; Vo, Phuc Leo H; Chen, Albert T; Tolar, Jakub; Osborn, Mark J; Sternberg, Samuel H; Liu, David R

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

利用不断进化的重组酶和先导编辑技术,将大型基因高效地位点特异性整合到哺乳动物细胞中。

Pandey, Smriti; Gao, Xin D; Krasnow, Nicholas A; McElroy, Amber; Tao, Y Allen; Duby, Jordyn E; Steinbeck, Benjamin J; McCreary, Julia; Pierce, Sarah E; Tolar, Jakub; Meissner, Torsten B; Chaikof, Elliot L; Osborn, Mark J; Liu, David R

Inflammasome-resistant IPSC-derived myeloid-derived suppressor cells ameliorate xenogeneic graft-versus-host disease

抗炎小体诱导多能干细胞来源的髓系来源抑制细胞可改善异种移植物抗宿主病

Ma, Lie; Koehn, Brent; Zaiken, Michael; Hippen, Keli L; Smith, Kyle; Allred, Jeremy; Williams, Robin; Yao, Ke; Fink, Jordan; Saha, Asim; Koop, Benjamin; Payne, Nathaniel; Widelak, Renata; Panoskaltsis-Mortari, Angela; Riddle, Megan J; Tolar, Jakub; Eide, Cindy; Xia, Lily; Witty, Alec D; Mehta, Amit K; Denholtz, Matthew; Hefazi, Mehrdad; Hani, Sophia; Kenderian, Saad S; Miller, Jeffrey S; Molldrem, Jeffrey J; Kean, Leslie S; Valamehr, Bahram; Blazar, Bruce R

Targeting cell-surface VISTA expression on allospecific naïve T cells promotes tolerance.

靶向同种异体特异性幼稚 T 细胞表面 VISTA 表达可促进耐受性

Koehn Brent H, Nowak Elizabeth C, Skopelja-Gardner Sladjana, Saha Asim, Zaiken Michael C, Allred Jeremy, Peng Yiyung, Davis Wilson L 3rd, Le Mercier Isabelle, Schwertner Nicholas, Molloy Michael J, Rothstein Jay, Carriere Catherine, Riddle Megan J, Eide Cindy R, Tolar Jakub, Panoskaltsis-Mortari Angela, Smith Kyle D, Hippen Keli L, Kim Tae Kon, Noelle Randolph J, Blazar Bruce R

Progress in skin gene therapy: From the inside and out

皮肤基因疗法的进展:由内而外

Osborn, Mark J; Panda, Sidharth; Reineke, Theresa M; Tolar, Jakub; Nyström, Alexander

Analysis of readability of the top web searches for pediatric inborn errors of fatty acid metabolism

对儿科先天性脂肪酸代谢异常相关热门网络搜索结果的可读性分析

Sawyer, Katelyn; Miller, William; Popp, Courtney; Strege, Chloe; Eide, Cindy; Tolar, Jakub

Contribution of HMGB1 to Keratinocyte inflammation in Recessive Dystrophic Epidermolysis Bullosa.

HMGB1 对隐性营养不良型大疱性表皮松解症角质形成细胞炎症的贡献

Bui Kacey Guenther, Chang Ya-Chu, Chiraphapphaiboon Wannasiri, Wang Jianfeng, Ebens Christen L, Bielinsky Anja-Katrin, Tolar Jakub, Nguyen Hai Dang

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice

在经 CD45 抗体药物偶联物预处理的范可尼贫血小鼠中,同种异体移植未出现明显毒性或移植物抗宿主病 (GVHD)。

Saha, Asim; Palchaudhuri, Rahul; Lanieri, Leanne; Hyzy, Sharon; Riddle, Megan J; Panthera, Jamie; Eide, Cindy R; Tolar, Jakub; Panoskaltsis-Mortari, Angela; Gorfinkel, Lev; Tkachev, Victor; Gerdemann, Ulrike; Alvarez-Calderon, Francesca; Palato, Elisa Rojas; MacMillan, Margaret L; Wagner, John E; Kean, Leslie S; Osborn, Mark J; Kiem, Hans-Peter; Scadden, David T; Olson, Lisa M; Blazar, Bruce R

Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid Nanoinjection

将多孔硅纳米针集成到用于核酸纳米注射的医疗器械中

Wang, Cong; Gu, Chenlei; Popp, Courtney; Vashisth, Priya; Mustfa, Salman Ahmad; Martella, Davide Alessandro; Spiteri, Chantelle; McLennan, Samuel; Sun, Ningjia; Riddle, Megan; Eide, Cindy R; Parsons, Maddy; Tolar, Jakub; McGrath, John A; Chiappini, Ciro