日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Correlative Biomarker Analysis of PSMA Expression on CTCs and PSMA Imaging in a Phase I Study of PSMA Targeted Tubulysin Conjugate EC1169

在PSMA靶向Tubulysin缀合物EC1169的I期研究中,对CTC上PSMA表达进行相关性生物标志物分析和PSMA成像

Zaidi, Samir; Kuo, Phillip H; Paiva Prudente, Tiago; Lacuna, Kristine P; Babiker, Hani M; Aparicio, Renan; Schonhoft, Joseph D; Fernandez, Luisa; Messmann, Richard; Groaning, Michael; Tolcher, Anthony W; Gordon, Michael S; Yoo, Don C; Vaishampayan, Ulka; Picus, Joel; Petrylak, Daniel P; Sartor, Oliver; Morris, Michael J

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

综合群体药代动力学、药效学和安全性分析,为ATR抑制剂Tuvusertib的临床开发中的剂量选择提供信息

Mukker, Jatinder Kaur; Diderichsen, Paul Matthias; Hellmann, Farina; Yap, Timothy A; Plummer, Ruth; Tolcher, Anthony W; de Bono, Johann S; Gounaris, Ioannis; Szucs, Zoltan; Zimmermann, Astrid; Kareva, Irina; Bolleddula, Jayaprakasam; Seithel-Keuth, Annick; Locatelli, Giuseppe; Enderlin, Marta; Hicking, Christine; Zutshi, Anup; Gao, Wei; Strotmann, Rainer; Benincosa, Lisa; Venkatakrishnan, Karthik

An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors

研究性ATRi药物Tuvusertib对实体瘤患者QTc间期影响的非临床和临床综合风险评估

Mukker, Jatinder Kaur; Yap, Timothy A; Tolcher, Anthony W; de Bono, Johann S; Plummer, Ruth; Grosser, Gary; van Amsterdam, Christoph; Schieferstein, Hanno; Witjes, Han; Diderichsen, Paul Matthias; Krebs-Brown, Axel; Gao, Wei; Strotmann, Rainer; Szucs, Zoltan; Gounaris, Ioannis; Venkatakrishnan, Karthik

TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial

TIGIT抑制剂M6223单药治疗或与bintrafusp alfa联合治疗晚期实体瘤患者:一项首次人体I期剂量递增试验

Naing, Aung; McKean, Meredith; Tolcher, Anthony; Victor, Anja; Hu, Ping; Gao, Wei; Nogueira Filho, Marco A F; Kitzing, Thomas; Gleicher, Stephan; Holland, Daniel; Richter, Emilia; Tadjalli-Mehr, Keyvan; Siu, Lillian L

A First-in-Human Study of Cinrebafusp Alfa, a HER2/4-1BB Bispecific Molecule, in Patients with HER2-Positive Advanced Solid Malignancies

Cinrebafusp Alfa(一种 HER2/4-1BB 双特异性分子)在 HER2 阳性晚期实体恶性肿瘤患者中的首次人体研究

Piha-Paul, Sarina; Olwill, Shane A; Hamilton, Erika; Tolcher, Anthony; Pohlmann, Paula; Liu, Stephen V; Wurzenberger, Cornelia; Hasenkamp, Laura-Carolin; Hansbauer, Eva-Maria; Shroff, Rachna; Hurvitz, Sara; Krishnamurthy, Anuradha; Patnaik, Amita; Hahn, Noah; Kumar, Raman; Duerr, Manuela; Zettl, Markus; Aviano, Kayti; Matis, Louis; Bruns, Ingmar; Ku, Geoffrey

A First-in-Human Study of ATM Inhibitor Lartesertib as Monotherapy in Patients with Advanced Solid Tumors

一项针对晚期实体瘤患者的ATM抑制剂Lartesertib单药治疗的首次人体研究

Siu, Lillian L; Yap, Timothy A; Genta, Sofia; Pennock, Gregory; Hicking, Christine; Vagge, Deepthi S; Mukker, Jatinder Kaur; Locatelli, Giuseppe; Tolcher, Anthony W

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism

AMXT 1501 二癸酸酯联合二氟甲基鸟氨酸的 I 期剂量递增试验:一种靶向免疫抑制性多胺代谢的双药疗法

Piha-Paul, S A; Tolcher, A W; Vandross, A L; Spira, A I; Burns, M R

Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2- and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study

Datopotamab Deruxtecan 治疗晚期或转移性 HR+/HER2- 和三阴性乳腺癌:来自 I 期 TROPION-PanTumor01 研究的结果

Bardia, Aditya; Krop, Ian E; Kogawa, Takahiro; Juric, Dejan; Tolcher, Anthony W; Hamilton, Erika P; Mukohara, Toru; Lisberg, Aaron; Shimizu, Toshio; Spira, Alexander I; Tsurutani, Junji; Damodaran, Senthil; Papadopoulos, Kyriakos P; Greenberg, Jonathan; Kobayashi, Fumiaki; Zebger-Gong, Hong; Wong, Rie; Kawasaki, Yui; Nakamura, Tadakatsu; Meric-Bernstam, Funda

First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors

首次人体研究:毛细血管扩张性共济失调和Rad3相关(ATR)抑制剂Tuvusertib(M1774)作为单药疗法治疗实体瘤患者

Yap, Timothy A; Tolcher, Anthony W; Plummer, Ruth; Mukker, Jatinder Kaur; Enderlin, Marta; Hicking, Christine; Grombacher, Thomas; Locatelli, Giuseppe; Szucs, Zoltan; Gounaris, Ioannis; de Bono, Johann S

Phase I Study of GS-3583, an FMS-like Tyrosine Kinase 3 Agonist Fc Fusion Protein, in Patients with Advanced Solid Tumors

GS-3583(一种FMS样酪氨酸激酶3激动剂Fc融合蛋白)在晚期实体瘤患者中的I期研究

Tolcher, Anthony W; Brody, Joshua D; Rajakumaraswamy, Nishanthan; Kuhne, Michelle; Trowe, Torsten; Dauki, Anees M; Pai, Shantheri; Han, Ling; Lin, Kai-Wen; Petrarca, Michael; Kummar, Shivaani