日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Phase I dose-escalation trial of AMXT 1501 dicaprate plus difluoromethylornithine: a dual-agent approach targeting immunosuppressive polyamine metabolism

AMXT 1501 二癸酸酯联合二氟甲基鸟氨酸的 I 期剂量递增试验:一种靶向免疫抑制性多胺代谢的双药疗法

Piha-Paul, S A; Tolcher, A W; Vandross, A L; Spira, A I; Burns, M R

A phase I study to evaluate the safety, pharmacokinetics, and pharmacodynamics of PF-06939999 (PRMT5 inhibitor) in patients with selected advanced or metastatic tumors with high incidence of splicing factor gene mutations

一项 I 期研究,旨在评估 PF-06939999(PRMT5 抑制剂)在具有高发剪接因子基因突变的特定晚期或转移性肿瘤患者中的安全性、药代动力学和药效学。

Rodon, J; Rodriguez, E; Maitland, M L; Tsai, F Y-C; Socinski, M A; Berlin, J D; Thomas, J S; Al Baghdadi, T; Wang, I-M; Guo, C; Golmakani, M; Clark, L N; Gazdoiu, M; Li, M; Tolcher, A W

PF-06952229, a selective TGF-β-R1 inhibitor: preclinical development and a first-in-human, phase I, dose-escalation study in advanced solid tumors

PF-06952229,一种选择性TGF-β-R1抑制剂:临床前开发和首次人体I期剂量递增研究(针对晚期实体瘤)

Yap, T A; Choudhury, A D; Hamilton, E; Rosen, L S; Stratton, K L; Gordon, M S; Schaer, D; Liu, L; Zhang, L; Mittapalli, R K; Zhong, W; Soman, N; Tolcher, A W

A Phase 1 study of ARQ 087, an oral pan-FGFR inhibitor in patients with advanced solid tumours

一项针对晚期实体瘤患者的口服泛FGFR抑制剂ARQ 087的I期研究

Papadopoulos, K P; El-Rayes, B F; Tolcher, A W; Patnaik, A; Rasco, D W; Harvey, R D; LoRusso, P M; Sachdev, J C; Abbadessa, G; Savage, R E; Hall, T; Schwartz, B; Wang, Y; Kazakin, J; Shaib, W L

P-171: The impact on survival of CPT-11 as third-line or later treatment in advanced gastric cancer

P-171:CPT-11作为晚期胃癌三线或后续治疗对生存率的影响

Sottoriva, A; Aravind, P; Thillai, K; Heaton, N; Suddel, A; Kane, P; Karani, J; Peddu, P; Lewis, D; Alkadhimi, G; Sarker, D; Ross, P; Faivre, S; Blanc, J-F; Merle, P; Fasolo, A; Iacobellis, A; Grando, V; Decaens, T; Trojan, J; Villa, E; Stammberger, U; Bruns, R; Raymond, E; Garcia, A; Cortesão, E; Pereira Marta, I; Ribeiro, L; Baratelli, C; Sonetto, C; Benedetto, S; Rubatto, E; Di Scipio, F; Pirro, E; Brizzi Maria, P; Di Maio, M; Berta Giovanni, N; Scagliotti Giorgio, V; Tampellini, M; Choi, HS; Chun, HJ; Lee, JM; Yoo, IK; Lee, JM; Kim, SH; Kim, ES; Keum, B; Jeen, YT; Lee, HS; Kim, CD; Keum, B; Yoo, IK; Lee, JM; Kim, SH; Choi, HS; Kim, ES; Jeen, YT; Chun, HJ; Kim, CD; Chun, HJ; Kim, SH; Lee, JM; Yoo, IK; Lee, JM; Choi, HS; Kim, ES; Keum, B; Jeen, YT; Lee, HS; Kim, CD; Demuth, C; Spindler, K-LG; Johansen, JS; Pallisgaard, N; Nielsen, D; Hoegdall, E; Vittrup, B; Sørensen, B; Yu, JI; Park, HC; Lim, DH; Kim, ST; Park, YS; Park, JO; Choi, SH; Choi, DW; Heo, JS; Lee, IK; Lee, YS; Oh, ST; Lim, A; Le Sourd, S; Senellart, H; Luet, D; Douane, F; Perret, C; Bouvier, A; Métairie, S; Cauchin, E; Philippe, Rougier; Tamara, Matysiak-Budnik; Touchefeu, Y; Kinoshita, J; Fushida, S; Kaji, M; Oyama, K; Hirono, Y; Nezuka, H; Takeda, T; Tsukada, T; Ohyama, S; Fujimura, T; Ohta, T; Andrew, Zhu; Peter, Galle; Masatoshi, Kudo; Richard, Finn; Ling, Yang; Paolo, Abada; Josep, Llovet; Michel, Ducreux; Alfredo, Falcone; Punt, Cornelis JA; Svetlana, Kobina; Manuel, O'Connor Juan; Andres, Cervantes; Pinninti, R; Ostwal, V; Ramaswamy, A; Banavali, S; Manish, Shah; Jaafar, Bennouna; Lin, Shen; Peter, Enzinger; Qiao, Li; Ildiko, Csiki; Minori, Koshiji; Toshihiko, Doi; Kim, TY; Yen, C-J; Al-Batran, S-E; Gao, L; Ferry, D; Hsu, Y; Cheng, R; Orlando, M; Ohtsu, A; Ostrizkova, L; Petruželka, L; Hejduk, K; Zdražilová-Dubská, L; Vocka, M; Brancikova, D; Bencsiková, B; Vyzula, R; Obermannová, R; Abrams, T; Hess, L; Zhu, Y; Schelman, W; Liepa, A; Fuchs, C; Fedyanin, M; Polyanskaya, E; Sekhina, O; Tryakin, A; Tjulandin, S; Khushman, M; Hosein, P; Cameron, D; Clarkson, D; Butler, T; Vu, M; Norden, C; Baliem, W; Jones, V; Bhadkamkar, S; Nelson, C; Lee, F; Singh, A; Taylor, W; Lumachi, F; Chiara, G; Tozzoli, R; Lo Re, G; Basso, S; Alexandersson von Döbeln, G; Wagenius, G; Holtved, E; Hjortland Geir, O; Nilsson, M; Baeksgaard, L; Szpejewska, J; Mørch, CD; Yilmaz, M; Arendt-Nielsen, L; Falkmer, U; Tsuji, A; Nakamura, M; Ogawa, M; Satake, H; Kotake, T; Hatachi, Y; Takagane, A; Okita, Y; Nakamura, K; Onikubo, T; Takeuchi, M; Fujii, M; Nakajima, T; Osumi, H; Shinozaki, E; Suenaga, M; Matsusaka, S; Nakayama, I; Wakatsuki, T; Ogura, M; Ozaka, M; Takashi, I; Takahari, D; Chin, K; Mizunuma, N; Yamaguchi, K; Haddad, P; Ali-Moghaddam, K; Mahmoodzadeh, H; Lashkari, M; Kalaghchi, B; Sharifi-Aliabadi, L; Jankovic, R; Stojanovic-Rundic, S; Micev, M; Krivokapic, Z; Nikolić, V; Popov, I; Gavrilovic, D; Plesinac-Karapandzic, V; Djuric-Stefanovic, A; Radulovic, S; Kishi, T; Matsuo, Y; Nakamura, A; Itasaka, S; Shibuya, K; Mizowaki, T; Hiraoka, M; Bhoriwal, S; Sultania, M; Kumar, S; Deo, S V S; Shukla, N; Pandey, D; Sharma, A; Sahoo, R; Pathy, S; Thulkar, S; Pathak, M; Bayramov, R; Huseynova, S; Abdullayeva, R; İbrahimov, V; Zamora Moreno, J; Ruiz-Garcia, E; Mitsoura, E; Estrada, G; Aiello Crocifoglio, V; Collisson, E; Ohliger, M; Yeh, B; Kelly, D; Pampaloni, M; Ko, A; Tempero, M; Wang, Z; Goto, Y; Nakamura, A; Kishi, T; Sakanaka, K; Itasaka, S; Shibuya, K; Matsumoto, S; Kodama, Y; Takaori, K; Mizowaki, T; Hiraoka, M; Su, CC; Kisro, J; Cohn, A; Yoshino, T; Van Cutsem, E; Hegewisch-Becker, S; Kullmann, F; Brück, P; Liepa, A; Yang, L; Nasroulah, F; Tabernero, J; Kotani, D; Pashtoon, K; Cecchini, M; Shitara, K; Ohtsu, A; Ramanathan, R; Hochster, H; Grothey, A; Yoshino, T; Spindler, K-L; Demuth, C; Soerensen, B; Johansen, J; Nielsen, D; Pallisgaard, N; Høgdall, E; Pfeiffer, P; Yilmaz, M; Jensen, B; Flander, L; Jenkins, M; Win Aung, K; Boussioutas, A; Hopper, J; Giles, G; Winship, I; Macrae, F; Ait Ouakrim, D; Hironaga, Satake; Akihito, Tsuji; Hiroki, Hashida; Hiroaki, Tanioka; Yasuhiro, Miyake; Takanori, Watanabe; Masato, Matsuura; Masahito, Kyogoku; Takeshi, Kotake; Yoshihiro, Okita; Yukimasa, Hatachi; Masahito, Kotaka; Takeshi, Kato; Satoshi, Kaihara; Negri, FV; Bozzetti, C; Azzoni, C; Bottarelli, L; Squadrilli, A; Pedrazzi, G; Lagrasta, C; Tamagnini, I; Bisagni, A; Porzio, R; Tomasello, G; Leonardi, F; Pinto, C; Ardizzoni, A; Sala, R; Quaini, F; Fakhry, H; Jaber, M; Hamza, H; Amira, G; Hatano, E; Uemoto, S; Castro, B; Aral, M; Fareleira, A; Costa-Maia, J; Santos-Sousa, H; Mazzaferro, V; Shaib, W; Rimassa, L; Harris, W; Personeni, N; El-Rayes, B; Tolcher, A; Hall, T; Wang, Y; Schwartz, B; Kazakin, J; Droz Dit Busset, M; Cotsoglou, C; Papadopoulos, K; Iseas, S; Coraglio, M; Dieguez, A; Eleta, M; Bertoncini, C; Tejerina, H; Carballido, M; Bianchi, R; Leiro, F; Mendez, G; Barugel, M; Roca, E; Sobrero, A; Douillard, J-Y; Rivera, F; Forget, F; Karthaus, M; Valladares-Ayerbes, M; Demonty, G; Guan, X; Peeters, M; Vještica, M; Jungic, S; Gojkovic, Z; Rakita, I; Berendika, J; Šipka, D; Ng, C; Chowbay, B; Choo, S P; Tai, D; Somasundaram, N; Yu, Y; Lam, S; Chang, Y; Magri, C; Buhagiar, A; Mifsud, M; Buhagiar, M; Uwagawa, T; Sakamoto, T; Nakaseko, Y; Takano, Y; Furukawa, K; Kanehira, M; Onda, S; Gocho, T; Shiba, H; Arakawa, Y; Aiba, K; Yanaga, K; Bringeland, EA; Wasmuth, HH; Mjønes, P; Myklebust, TÅ; Grønbech, JE; Gaballah, A; Moawad, M; Yassin, M; El-Wasly, N; El-Mahdy, M; Saha, S; Ghosh Dastidar, A; Gupta, S; Sarkar, S; Athmanathan, S; Worlding, J; Baragwanath, P; Williams, N; Manolopoulos, S; Brown, M; Correa, P; Longo Muñoz, F; Earl, J; Martinez Avila, J; Rodriguez Garrote, M; Guerrero, C; Galindo, J; Priego, P; Rodriguez, G; García-Moreno, F; Lopez, F; Hervás, A; Caminoa, A; García, I; Soteras, C; Vázquez-Sequeiros, E; Botella, J; Pachón Olmos, V; Ferreiro Monteagudo, R; Vaz, M; Gómez, A; Guillén-Ponce, C; Carrato, A; Cortesi, E; Masi, G; Mancini, M; Caponnetto, S; Urbano, F; Mosillo, C; Scagnoli, S; Notarianni, E; Pelle, G; Vivaldi, C; Falcone, A; Cianni, R; Iwamoto, S; Hazama, S; Kin, H; Takemoto, H; Kobayashi, K; Takahashi, Y; Kobayashi, M; Maeda, H; Nagata, N; Oba, K; Sakamoto, J; Mishima, H; Makiyama, A; Arimizu, K; Hirano, G; Makiyama, C; Matsushita, Y; Shirakawa, T; Ohmura, H; Komoda, M; Uchino, K; Inadomi, K; Kusaba, H; Shinohara, Y; Kuwayama, M; Kajitani, T; Esaki, T; Baba, E

First-in-human phase I study of copanlisib (BAY 80-6946), an intravenous pan-class I phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors and non-Hodgkin's lymphomas

copanlisib (BAY 80-6946) 是一种静脉注射的泛 I 类磷脂酰肌醇 3-激酶抑制剂,用于治疗晚期实体瘤和非霍奇金淋巴瘤患者,这是首次人体 I 期研究。

Patnaik, A; Appleman, L J; Tolcher, A W; Papadopoulos, K P; Beeram, M; Rasco, D W; Weiss, G J; Sachdev, J C; Chadha, M; Fulk, M; Ejadi, S; Mountz, J M; Lotze, M T; Toledo, F G S; Chu, E; Jeffers, M; Peña, C; Xia, C; Reif, S; Genvresse, I; Ramanathan, R K

Phase I ficlatuzumab monotherapy or with erlotinib for refractory advanced solid tumours and multiple myeloma.

ficlatuzumab 单药治疗或与厄洛替尼联合治疗难治性晚期实体瘤和多发性骨髓瘤的 I 期临床试验

Patnaik A, Weiss G J, Papadopoulos K P, Hofmeister C C, Tibes R, Tolcher A, Isaacs R, Jac J, Han M, Payumo F C, Cotreau M M, Ramanathan R K

Phase I study of humanized monoclonal antibody AVE1642 directed against the type 1 insulin-like growth factor receptor (IGF-1R), administered in combination with anticancer therapies to patients with advanced solid tumors

针对1型胰岛素样生长因子受体(IGF-1R)的人源化单克隆抗体AVE1642的I期研究,该抗体与抗癌疗法联合用于治疗晚期实体瘤患者。

Macaulay, V M; Middleton, M R; Protheroe, A S; Tolcher, A; Dieras, V; Sessa, C; Bahleda, R; Blay, J-Y; LoRusso, P; Mery-Mignard, D; Soria, J-C

Effect of abiraterone acetate plus prednisone on the QT interval in patients with metastatic castration-resistant prostate cancer

醋酸阿比特龙联合泼尼松对转移性去势抵抗性前列腺癌患者QT间期的影响

Tolcher, A W; Chi, K N; Shore, N D; Pili, R; Molina, A; Acharya, M; Kheoh, T; Jiao, J J; Gonzalez, M; Trinh, A; Pankras, C; Tran, N

Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors

一项针对晚期实体瘤患者的lexatumumab (HGS-ETR2) 每2周给药一次的I期和药代动力学研究

Wakelee, H A; Patnaik, A; Sikic, B I; Mita, M; Fox, N L; Miceli, R; Ullrich, S J; Fisher, G A; Tolcher, A W