日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mithramycin alters EWS::FLI1 DNA binding and RNA polymerase II processivity to inhibit nascent transcription

米索霉素通过改变 EWS::FLI1 与 DNA 的结合以及 RNA 聚合酶 II 的加工能力来抑制新生转录。

Kaufman, Rebecca; Flores, Guillermo; Boguslawski, Elissa A; Kinn-Gurzo, Seneca; Chassé, Maggie; Beddows, Ian; Adams, Marie; Stout, Matthew C; Gaetano, Lauren; Lopez, Raphael; Veluvolu, Sridhar; Fuller, Andrew; Kitchen-Goosen, Susan M; Tolstyka, Zachary P; Gedminas, Jenna M; Grohar, Patrick J

Exploiting divergent mechanisms of trabectedin for bone tumors

利用曲贝替定治疗骨肿瘤的不同机制

Tolstyka, Zachary P; Grohar, Patrick J

Uridine-derived ribose fuels glucose-restricted pancreatic cancer

尿苷衍生的核糖为葡萄糖受限的胰腺癌提供能量

Zeribe C Nwosu # ,Matthew H Ward # ,Peter Sajjakulnukit # ,Pawan Poudel # ,Chanthirika Ragulan ,Steven Kasperek ,Megan Radyk ,Damien Sutton ,Rosa E Menjivar ,Anthony Andren ,Juan J Apiz-Saab ,Zachary Tolstyka ,Kristee Brown ,Ho-Joon Lee ,Lindsey N Dzierozynski ,Xi He ,Hari Ps ,Julia Ugras ,Gift Nyamundanda ,Li Zhang ,Christopher J Halbrook ,Eileen S Carpenter ,Jiaqi Shi ,Leah P Shriver ,Gary J Patti ,Alexander Muir ,Marina Pasca di Magliano ,Anguraj Sadanandam ,Costas A Lyssiotis

Cysteine depletion induces pancreatic tumor ferroptosis in mice

小鼠体内半胱氨酸耗竭可诱导胰腺肿瘤发生铁死亡。

Badgley, Michael A; Kremer, Daniel M; Maurer, H Carlo; DelGiorno, Kathleen E; Lee, Ho-Joon; Purohit, Vinee; Sagalovskiy, Irina R; Ma, Alice; Kapilian, Jonathan; Firl, Christina E M; Decker, Amanda R; Sastra, Steve A; Palermo, Carmine F; Andrade, Leonardo R; Sajjakulnukit, Peter; Zhang, Li; Tolstyka, Zachary P; Hirschhorn, Tal; Lamb, Candice; Liu, Tong; Gu, Wei; Seeley, E Scott; Stone, Everett; Georgiou, George; Manor, Uri; Iuga, Alina; Wahl, Geoffrey M; Stockwell, Brent R; Lyssiotis, Costas A; Olive, Kenneth P

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

组织来源决定了GOT1依赖性,并赋予放射疗法合成致死性。

Barbara S Nelson # ,Lin Lin # ,Daniel M Kremer ,Cristovão M Sousa ,Cecilia Cotta-Ramusino ,Amy Myers ,Johanna Ramos ,Tina Gao ,Ilya Kovalenko ,Kari Wilder-Romans ,Joseph Dresser ,Mary Davis ,Ho-Joon Lee ,Zeribe C Nwosu ,Scott Campit ,Oksana Mashadova ,Brandon N Nicolay ,Zachary P Tolstyka ,Christopher J Halbrook ,Sriram Chandrasekaran ,John M Asara ,Howard C Crawford ,Lewis C Cantley ,Alec C Kimmelman ,Daniel R Wahl ,Costas A Lyssiotis

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma

安静基因组背景下的异常氧化代谢是透明细胞乳头状肾细胞癌的基础

Jianing Xu #, Ed Reznik #, Ho-Joon Lee, Gunes Gundem, Philip Jonsson, Judy Sarungbam, Anna Bialik, Francisco Sanchez-Vega, Chad J Creighton, Jake Hoekstra, Li Zhang, Peter Sajjakulnukit, Daniel Kremer, Zachary Tolstyka, Jozefina Casuscelli, Steve Stirdivant, Jie Tang, Nikolaus Schultz, Paul Jeng, Yi

Correction to Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery

对基于海藻糖的嵌段共聚阳离子进行校正可促进聚合物复合物的稳定,从而实现冻干和体内pDNA递送。

Tolstyka, Zachary P; Phillips, Haley; Cortez, Mallory; Wu, Yaoying; Ingle, Nilesh; Bell, Jason B; Hackett, Perry B; Reineke, Theresa M

High-Throughput Excipient Discovery Enables Oral Delivery of Poorly Soluble Pharmaceuticals

高通量辅料发现技术实现难溶性药物的口服递送

Ting, Jeffrey M; Tale, Swapnil; Purchel, Anatolii A; Jones, Seamus D; Widanapathirana, Lakmini; Tolstyka, Zachary P; Guo, Li; Guillaudeu, Steven J; Bates, Frank S; Reineke, Theresa M

Trehalose-Based Block Copolycations Promote Polyplex Stabilization for Lyophilization and in Vivo pDNA Delivery

基于海藻糖的嵌段共聚阳离子促进聚合物复合物的稳定,从而实现冻干和体内pDNA递送。

Tolstyka, Zachary P; Phillips, Haley; Cortez, Mallory; Wu, Yaoying; Ingle, Nilesh; Bell, Jason B; Hackett, Perry B; Reineke, Theresa M

Poly(trehalose): sugar-coated nanocomplexes promote stabilization and effective polyplex-mediated siRNA delivery

聚海藻糖:糖包覆的纳米复合物可促进稳定化和有效的聚合物介导的siRNA递送。

Sizovs, Antons; Xue, Lian; Tolstyka, Zachary P; Ingle, Nilesh P; Wu, Yaoying; Cortez, Mallory; Reineke, Theresa M