文献库，生知库 | 链接生命科学的每一步

日期影响因子

Single-Molecule Methods to Investigate Mechanisms of Transcription by RNA Polymerase of Mycobacterium tuberculosis

利用单分子方法研究结核分枝杆菌RNA聚合酶的转录机制

doi:10.64898/2026.03.27.714832

Lin, Wenxia; Herrera-Asmat, Omar; Tong, Alexander B; Kong, Tiantian; Bustamante, Carlos

发表日期：2026

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FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate.

FACT 通过形成六聚体样中间体来削弱核小体对转录的屏障并保持其完整性

期刊:Molecular Cell

影响因子:16.6

doi:10.1016/j.molcel.2025.05.002

Burgos-Bravo Francesca, Tong Alexander B, Li Chen, DÃaz-Celis CÃ©sar, Kaplan Craig D, LeRoy Gary, Reinberg Danny, Bustamante Carlos

发表日期：2025

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A structural atlas of death domain fold proteins reveals their versatile roles in biology and function

死亡结构域折叠蛋白的结构图谱揭示了它们在生物学和功能中的多种作用

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2426986122

Wu, Emily J; Kandalkar, Ankita T; Ehrmann, Julian F; Tong, Alexander B; Zhang, Jing; Cong, Qian; Wu, Hao

发表日期：2025

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Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase

三种小分子抑制剂对结核分枝杆菌RNA聚合酶转录延伸的多形性影响

影响因子:6.4

doi:10.7554/eLife.105545

Herrera-Asmat, Omar; Tong, Alexander B; Lin, Wenxia; Kong, Tiantian; Del Valle, Juan R; Guerra, Daniel G; Ebright, Yon W; Ebright, Richard H; Bustamante, Carlos

发表日期：2025

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Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1

人类ESCRT-III蛋白CHMP1B和IST1通过摩擦驱动膜断裂

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2204536119

Cada, A King; Pavlin, Mark R; Castillo, Juan P; Tong, Alexander B; Larsen, Kevin P; Ren, Xuefeng; Yokom, Adam L; Tsai, Feng-Ching; Shiah, Jamie V; Bassereau, Patricia M; Bustamante, Carlos J; Hurley, James H

发表日期：2022

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Could AlphaFold revolutionize chemical therapeutics?

AlphaFold能否彻底改变化学疗法？

期刊:Nature Structural & Molecular Biology

影响因子:10.1

doi:10.1038/s41594-021-00670-x

Tong, Alexander B; Burch, Jason D; McKay, Daniel; Bustamante, Carlos; Crackower, Michael A; Wu, Hao

发表日期：2021

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Helical inchworming: a novel translocation mechanism for a ring ATPase

螺旋蠕动：一种新型的环状ATPase易位机制

期刊:Biophysical Reviews

影响因子:3.7

doi:10.1007/s12551-021-00883-w

Tong, Alexander B; Bustamante, Carlos

发表日期：2021

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Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

caspase-1聚合的分子基础及其通过一种新的加帽机制的抑制

期刊:Nature Structural & Molecular Biology

影响因子:10.1

doi:10.1038/nsmb.3199

Lu, Alvin; Li, Yang; Schmidt, Florian I; Yin, Qian; Chen, Shuobing; Fu, Tian-Min; Tong, Alexander B; Ploegh, Hidde L; Mao, Youdong; Wu, Hao

发表日期：2016

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Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

活化的NAIP2-NLRC4炎症小体的冷冻电镜结构揭示了成核聚合作用

影响因子:45.8

doi:10.1126/science.aac5789

Zhang, Liman; Chen, Shuobing; Ruan, Jianbin; Wu, Jiayi; Tong, Alexander B; Yin, Qian; Li, Yang; David, Liron; Lu, Alvin; Wang, Wei Li; Marks, Carolyn; Ouyang, Qi; Zhang, Xinzheng; Mao, Youdong; Wu, Hao

免疫/内分泌

发表日期：2015

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