日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing.

通过间充质干细胞定向分化和分层3D打印技术构建椎间盘类器官。

期刊:ACS Nano
影响因子:16
doi:10.1021/acsnano.5c14391
Wu Di, Zhu Dingchao, Zhou Xingyu, Li Gaocai, Zhang Xiaoguang, Ma Liang, Liang Huaizhen, Tong Bide, Lei Jie, Wang Hongchuan, Ke Wencan, Feng Xiaobo, Wang Kun, Tan Lei, Shi Yunsong, Yang Cao, Wang Bingjin
发育与干细胞
干细胞
3D/类器官
发表日期：2026
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Microneedle delivery of CAR-M-like engineered macrophages alleviates intervertebral disc degeneration through enhanced efferocytosis capacity

微针递送CAR-M样工程化巨噬细胞可通过增强胞吞作用缓解椎间盘退变

期刊:Cell Reports Medicine
影响因子:10.6
doi:10.1016/j.xcrm.2026.102620
Zhou, Xingyu; Zhu, Dingchao; Wu, Di; Li, Gaocai; Liang, Huaizhen; Zhang, Weifeng; Wu, Yali; Xu, Hanpeng; Zhang, Zhengdong; Tong, Bide; Song, Yu; Wang, Kun; Feng, Xiaobo; Lei, Jie; Wang, Hongchuan; Zhang, Xiaoguang; Ma, Liang; Chen, Yuhang; Wei, Junyu; Ou, Zixuan; Peng, Shuchang; Wu, Xinghuo; Tan, Lei; Wang, Bingjin; Yang, Cao
巨噬细胞
巨噬细胞
细胞生物学
免疫/内分泌
发表日期：2026
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Extracellular vesicle-based targeted protein degradation platform for multiple extracellular proteins.

基于细胞外囊泡的靶向蛋白降解平台，适用于多种细胞外蛋白。

期刊:EMBO Molecular Medicine
影响因子:8.3
doi:10.1038/s44321-025-00371-8
Tong Bide, Zhang Xiaoguang, Zhu Dingchao, Wang Yulei, Wei Junyu, Ou Zixuan, Liang Huaizhen, Xu Hanpeng, Zhang Zhengdong, Lei Jie, Zhou Xingyu, Wu Di, Song Yu, Wang Kun, Feng Xiaobo, Tan Lei, Liao Zhiwei, Yang Cao
细胞生物学
蛋白降解
囊泡
发表日期：2026
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DDX1 methylation mediated MATR3 splicing regulates intervertebral disc degeneration by initiating chromatin reprogramming

DDX1甲基化介导的MATR3剪接通过启动染色质重编程来调控椎间盘退变

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-61486-7
Zhu, Dingchao; Liang, Huaizhen; Tong, Bide; Du, Zhi; Li, Gaocai; Zhang, Weifeng; Wu, Di; Zhou, Xingyu; Lei, Jie; Zhang, Xiaoguang; Ma, Liang; Wang, Bingjin; Feng, Xiaobo; Wang, Kun; Tan, Lei; Song, Yu; Yang, Cao
信号转导
DDX1
表观遗传
ATR
发表日期：2025
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An overview of mechanical microenvironment and mechanotransduction in intervertebral disc degeneration

椎间盘退变中机械微环境和力学传导的概述

期刊:Experimental and Molecular Medicine
影响因子:12.9
doi:10.1038/s12276-025-01546-6
Ke, Wencan; Xu, Hanpeng; Zhang, Chengyi; Liao, Zhiwei; Liang, Huaizhen; Tong, Bide; Yuan, Feijun; Wang, Kun; Hua, Wenbin; Wang, Bingjin; Yang, Cao
发表日期：2025
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Customized extracellular vesicles targeting lysosomal biogenesis deliver therapeutic cargo for intervertebral disc degeneration treatment

靶向溶酶体生物合成的定制化细胞外囊泡可将治疗性药物递送至椎间盘退变部位进行治疗。

期刊:Journal of Nanobiotechnology
影响因子:12.6
doi:10.1186/s12951-025-03772-6
Liao, Zhiwei; Ou, Zixuan; Tong, Bide; Li, Shuai; Yang, Cao
囊泡
细胞生物学
发表日期：2025
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A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation.

利用靶向细胞周期调控实现非侵入性椎间盘再生的声电微环境

期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.adu6860
Zhang Xiaoguang, Liang Huaizhen, Liao Zhiwei, Tong Bide, Wu Di, Ma Liang, Lei Jie, Zhou Xingyu, Zhu Dingchao, Ou Zixuan, Wei Junyu, Tan Lei, Yang Cao
细胞生物学
发表日期：2025
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Addressing osteoblast senescence: Molecular pathways and the frontier of anti-ageing treatments

解决成骨细胞衰老问题：分子通路与抗衰老治疗的前沿

期刊:Clinical and Translational Medicine
影响因子:6.8
doi:10.1002/ctm2.70417
Zhang, Zhengdong; Liu, Pan; Song, Yu; Ma, Liang; Xu, Yan; Lei, Jie; Tong, Bide; Zhu, Dingchao; Liang, Huaizhen; Wang, Hongchuan; Zhou, Xingyu; Ou, Zixuan; Wei, Junyu; Xu, Hanpeng; Wu, Di; Peng, Shuchang; Du, Yifan; Du, Zhi; Wang, Bingjin; Liao, Zhiwei; Ke, Wencan; Zhao, Kangcheng; Xia, Xiqin; Tan, Lei; Feng, Xiaobo; Liu, Gang; Li, Shuai; Wang, Kun; Yang, Cao
信号转导
细胞生物学
细胞衰老
衰老
发表日期：2025
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Disassembly of the TRIM56-ATR complex promotes cytoDNA/cGAS/STING axis-dependent intervertebral disc inflammatory degeneration

TRIM56-ATR复合物的解离促进细胞DNA/cGAS/STING轴依赖性的椎间盘炎症性退变。

期刊:Journal of Clinical Investigation
影响因子:13.6
doi:10.1172/JCI165140
Zhang, Weifeng; Li, Gaocai; Zhou, Xingyu; Liang, Huaizhen; Tong, Bide; Wu, Di; Yang, Kevin; Song, Yu; Wang, Bingjin; Liao, Zhiwei; Ma, Liang; Ke, Wencan; Zhang, Xiaoguang; Lei, Jie; Lei, Chunchi; Feng, Xiaobo; Wang, Kun; Zhao, Kangcheng; Yang, Cao
ATR
STING
炎症
细胞生物学
炎症/感染
发表日期：2024
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