日期 影响因子
日期:
2020 年 — 2026 年
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影响因子:
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Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia

对6,7-二氢吡唑并[1,5-a]吡嗪-4-酮衍生物作为一类新型mGlu5受体正向变构调节剂的初步研究，该类化合物在精神分裂症的临床前模型中显示出疗效

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2015.11.098
Conde-Ceide, Susana; Alcázar, Jesús; Alonso de Diego, Sergio A; López, Silvia; Martín-Martín, María Luz; Martínez-Viturro, Carlos M; Pena, Miguel-Angel; Tong, Han Min; Lavreysen, Hilde; Mackie, Claire; Bridges, Thomas M; Daniels, J Scott; Niswender, Colleen M; Jones, Carrie K; Macdonald, Gregor J; Steckler, Thomas; Conn, P Jeffrey; Stauffer, Shaun R; Lindsley, Craig W; Bartolomé-Nebreda, José Manuel
信号转导
精神分裂症
神经科学
发表日期：2016
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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)

发现并研究新型咪唑并嘧啶酮和二氢咪唑并嘧啶酮类化合物作为代谢型谷氨酸受体5 (mGlu5) 正向变构调节剂的构效关系

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2015.01.038
Martín-Martín, María Luz; Bartolomé-Nebreda, José Manuel; Conde-Ceide, Susana; Alonso de Diego, Sergio A; López, Silvia; Martínez-Viturro, Carlos M; Tong, Han Min; Lavreysen, Hilde; Macdonald, Gregor J; Steckler, Thomas; Mackie, Claire; Bridges, Thomas M; Daniels, J Scott; Niswender, Colleen M; Noetzel, Meredith J; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W; Stauffer, Shaun R
信号转导
代谢
发表日期：2015
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Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu₠).

四氢萘啶和二氢萘啶酮醚作为代谢型谷氨酸受体 5 (mGluâ‚) 的正向变构调节剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/jm500259z
Turlington Mark, Malosh Chrysa, Jacobs Jon, Manka Jason T, Noetzel Meredith J, Vinson Paige N, Jadhav Satyawan, Herman Elizabeth J, Lavreysen Hilde, Mackie Claire, Bartolomé-Nebreda José M, Conde-Ceide Susana, Martín-Martín M Luz, Tong Han Min, López Silvia, MacDonald Gregor J, Steckler Thomas, Daniels J Scott, Weaver C David, Niswender Colleen M, Jones Carrie K, Conn P Jeffrey, Lindsley Craig W, Stauffer Shaun R
代谢
发表日期：2014
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Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

发现并研究了一系列新型代谢型谷氨酸受体5正向变构调节剂的构效关系及其配体效率

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2014.04.087
Turlington, Mark; Noetzel, Meredith J; Bridges, Thomas M; Vinson, Paige N; Steckler, Thomas; Lavreysen, Hilde; Mackie, Claire; Bartolomé-Nebreda, José M; Conde-Ceide, Susana; Tong, Han Min; Macdonald, Gregor J; Daniels, J Scott; Jones, Carrie K; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Stauffer, Shaun R
信号转导
代谢
发表日期：2014
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