日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models

一种寨卡病毒NS2B-NS3蛋白酶的变构抑制剂,在小鼠模型中具有口服疗效。

Ontoria, Jesus M; Torrente, Esther; Missineo, Antonino; Alli, Cristina; Graziani, Rita; Conti, Silvia; Bisbocci, Monica; Quotadamo, Antonio; Ferrigno, Federica; Corio, Alessandra; Ievoli, Giovanni; Bencheva, Leda; Amaudrut, Jérôme; Vasile, Silvana; Beghetto, Elisa; Paolini, Chantal; Alaimo, Nadine; Veneziano, Maria; Nibbio, Martina; Orsale, Maria V; Proto, Giulia; Colaceci, Fabrizio; Orsatti, Laura; Pucci, Vincenzo; Di Fabio, Romano; Tomei, Licia; Montalbetti, Christian; Bresciani, Alberto; Toniatti, Carlo; Paonessa, Giacomo

Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors

发现一系列新型高效SHP2变构抑制剂

Petrocchi, Alessia; Grillo, Alessandro; Ferrante, Luca; Randazzo, Pietro; Prandi, Adolfo; De Matteo, Marilenia; Iaccarino, Costanza; Bisbocci, Monica; Cellucci, Antonella; Alli, Cristina; Nibbio, Martina; Pucci, Vincenzo; Amaudrut, Jérôme; Montalbetti, Christian; Toniatti, Carlo; Di Fabio, Romano

Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes

通过对恶性疟原虫配子体进行高通量筛选发现配子体特异性和全血液阶段传播阻断化学型

Giacomo Paonessa #, Giulia Siciliano #, Rita Graziani, Cristiana Lalli, Ottavia Cecchetti, Cristina Alli, Roberto La Valle, Alessia Petrocchi, Alessio Sferrazza, Monica Bisbocci, Mario Falchi, Carlo Toniatti, Alberto Bresciani, Pietro Alano

Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair

Prdm16 介导的 H3K9 甲基化控制骨骼肌修复过程中的纤维脂肪形成祖细胞身份

Beatrice Biferali, Valeria Bianconi, Daniel Fernandez Perez, Sophie Pöhle Kronawitter, Fabrizia Marullo, Roberta Maggio, Tiziana Santini, Federica Polverino, Stefano Biagioni, Vincenzo Summa, Carlo Toniatti, Diego Pasini, Sigmar Stricker, Romano Di Fabio, Fulvio Chiacchiera, Giovanna Peruzzi, Chiara

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer

胰腺癌间充质亚群的合成脆弱性

Giannicola Genovese,Alessandro Carugo ,James Tepper,Frederick Scott Robinson,Liren Li,Maria Svelto,Luigi Nezi,Denise Corti,Rosalba Minelli,Piergiorgio Pettazzoni,Tony Gutschner,Chia-Chin Wu,Sahil Seth,Kadir Caner Akdemir,Elisabetta Leo,Samirkumar Amin,Marco Dal Molin,Haoqiang Ying,Lawrence N Kwong,Simona Colla,Koichi Takahashi,Papia Ghosh,Virginia Giuliani,Florian Muller,Prasenjit Dey,Shan Jiang,Jill Garvey,Chang-Gong Liu,Jianhua Zhang,Timothy P Heffernan,Carlo Toniatti,Jason B Fleming,Michael G Goggins,Laura D Wood,Alessandro Sgambato,Abbas Agaimy,Anirban Maitra,Charles W M Roberts,Huamin Wang,Andrea Viale,Ronald A DePinho,Giulio F Draetta,Lynda Chin

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination

溶瘤腺病毒和肿瘤靶向免疫调节疗法可改善自体癌症疫苗接种

Hong Jiang ,Yisel Rivera-Molina ,Candelaria Gomez-Manzano ,Karen Clise-Dwyer ,Laura Bover ,Luis M Vence ,Ying Yuan ,Frederick F Lang ,Carlo Toniatti ,Mohammad B Hossain ,Juan Fueyo

Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

雄激素受体抑制剂诱导的“BRCA样”和PARP抑制对去势抵抗性前列腺癌具有合成致死作用。

Li, Likun; Karanika, Styliani; Yang, Guang; Wang, Jiangxiang; Park, Sanghee; Broom, Bradley M; Manyam, Ganiraju C; Wu, Wenhui; Luo, Yong; Basourakos, Spyridon; Song, Jian H; Gallick, Gary E; Karantanos, Theodoros; Korentzelos, Dimitrios; Azad, Abul Kalam; Kim, Jeri; Corn, Paul G; Aparicio, Ana M; Logothetis, Christopher J; Troncoso, Patricia; Heffernan, Timothy; Toniatti, Carlo; Lee, Hyun-Sung; Lee, Ju-Seog; Zuo, Xuemei; Chang, Wenjun; Yin, Jianhua; Thompson, Timothy C

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

MEK 和 CDK4/6 抑制剂联合治疗 KRAS 突变结直肠癌模型的体内外疗效

Michael S Lee, Timothy L Helms, Ningping Feng, Jason Gay, Qing Edward Chang, Feng Tian, Ji Y Wu, Carlo Toniatti, Timothy P Heffernan, Garth Powis, Lawrence N Kwong, Scott Kopetz

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.

共存的基因组改变定义了 KRAS 突变肺腺癌的主要亚型,这些亚型具有不同的生物学特性、免疫特征和治疗脆弱性

Skoulidis Ferdinandos, Byers Lauren A, Diao Lixia, Papadimitrakopoulou Vassiliki A, Tong Pan, Izzo Julie, Behrens Carmen, Kadara Humam, Parra Edwin R, Canales Jaime Rodriguez, Zhang Jianjun, Giri Uma, Gudikote Jayanthi, Cortez Maria A, Yang Chao, Fan Youhong, Peyton Michael, Girard Luc, Coombes Kevin R, Toniatti Carlo, Heffernan Timothy P, Choi Murim, Frampton Garrett M, Miller Vincent, Weinstein John N, Herbst Roy S, Wong Kwok-Kin, Zhang Jianhua, Sharma Padmanee, Mills Gordon B, Hong Waun K, Minna John D, Allison James P, Futreal Andrew, Wang Jing, Wistuba Ignacio I, Heymach John V

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

SMARCA2/4 ATPase 结构域在 SWI/SNF 突变癌症中作为药物靶标的作用优于溴结构域:来自 cDNA 拯救和 PFI-3 抑制剂研究的见解

Bhavatarini Vangamudi, Thomas A Paul #, Parantu K Shah #, Maria Kost-Alimova, Lisa Nottebaum, Xi Shi, Yanai Zhan, Elisabetta Leo, Harshad S Mahadeshwar, Alexei Protopopov, Andrew Futreal, Trang N Tieu, Mike Peoples, Timothy P Heffernan, Joseph R Marszalek, Carlo Toniatti, Alessia Petrocchi, Dominiqu