日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models

一种寨卡病毒NS2B-NS3蛋白酶的变构抑制剂,在小鼠模型中具有口服疗效。

Ontoria, Jesus M; Torrente, Esther; Missineo, Antonino; Alli, Cristina; Graziani, Rita; Conti, Silvia; Bisbocci, Monica; Quotadamo, Antonio; Ferrigno, Federica; Corio, Alessandra; Ievoli, Giovanni; Bencheva, Leda; Amaudrut, Jérôme; Vasile, Silvana; Beghetto, Elisa; Paolini, Chantal; Alaimo, Nadine; Veneziano, Maria; Nibbio, Martina; Orsale, Maria V; Proto, Giulia; Colaceci, Fabrizio; Orsatti, Laura; Pucci, Vincenzo; Di Fabio, Romano; Tomei, Licia; Montalbetti, Christian; Bresciani, Alberto; Toniatti, Carlo; Paonessa, Giacomo

Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors

发现一系列新型高效SHP2变构抑制剂

Petrocchi, Alessia; Grillo, Alessandro; Ferrante, Luca; Randazzo, Pietro; Prandi, Adolfo; De Matteo, Marilenia; Iaccarino, Costanza; Bisbocci, Monica; Cellucci, Antonella; Alli, Cristina; Nibbio, Martina; Pucci, Vincenzo; Amaudrut, Jérôme; Montalbetti, Christian; Toniatti, Carlo; Di Fabio, Romano

Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

雄激素受体抑制剂诱导的“BRCA样”和PARP抑制对去势抵抗性前列腺癌具有合成致死作用。

Li, Likun; Karanika, Styliani; Yang, Guang; Wang, Jiangxiang; Park, Sanghee; Broom, Bradley M; Manyam, Ganiraju C; Wu, Wenhui; Luo, Yong; Basourakos, Spyridon; Song, Jian H; Gallick, Gary E; Karantanos, Theodoros; Korentzelos, Dimitrios; Azad, Abul Kalam; Kim, Jeri; Corn, Paul G; Aparicio, Ana M; Logothetis, Christopher J; Troncoso, Patricia; Heffernan, Timothy; Toniatti, Carlo; Lee, Hyun-Sung; Lee, Ju-Seog; Zuo, Xuemei; Chang, Wenjun; Yin, Jianhua; Thompson, Timothy C

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

基于结构的IACS-9571设计:一种选择性高亲和力双重TRIM24-BRPF1溴结构域抑制剂

Palmer, Wylie S; Poncet-Montange, Guillaume; Liu, Gang; Petrocchi, Alessia; Reyna, Naphtali; Subramanian, Govindan; Theroff, Jay; Yau, Anne; Kost-Alimova, Maria; Bardenhagen, Jennifer P; Leo, Elisabetta; Shepard, Hannah E; Tieu, Trang N; Shi, Xi; Zhan, Yanai; Zhao, Shuping; Barton, Michelle C; Draetta, Giulio; Toniatti, Carlo; Jones, Philip; Geck Do, Mary; Andersen, Jannik N

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.

共存的基因组改变定义了 KRAS 突变肺腺癌的主要亚型,这些亚型具有不同的生物学特性、免疫特征和治疗脆弱性

Skoulidis Ferdinandos, Byers Lauren A, Diao Lixia, Papadimitrakopoulou Vassiliki A, Tong Pan, Izzo Julie, Behrens Carmen, Kadara Humam, Parra Edwin R, Canales Jaime Rodriguez, Zhang Jianjun, Giri Uma, Gudikote Jayanthi, Cortez Maria A, Yang Chao, Fan Youhong, Peyton Michael, Girard Luc, Coombes Kevin R, Toniatti Carlo, Heffernan Timothy P, Choi Murim, Frampton Garrett M, Miller Vincent, Weinstein John N, Herbst Roy S, Wong Kwok-Kin, Zhang Jianhua, Sharma Padmanee, Mills Gordon B, Hong Waun K, Minna John D, Allison James P, Futreal Andrew, Wang Jing, Wistuba Ignacio I, Heymach John V