日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency

Gata2单倍体不足导致造血干细胞缺陷的根本原因是DNA损伤反应和炎症信号传导受损。

Abdelfattah, Ali; Habib, Ahmad; Thomas, Leigh-Anne; Menendez-Gonzalez, Juan Bautista; Almotiri, Alhomidi; Alqahtani, Hind; Lawson, Hannah; Taha, Sarab; Steadman, Millie; Athalye, Radhika; Gibbs, Alex; Alzahrani, Hamed; Alshahrani, Ali; Cato, Alice; Giles, Peter; Tonks, Alex; Boyd, Ashleigh S; Kranc, Kamil R; Rodrigues, Neil P

Reactive oxygen species and its role in pathogenesis and resistance to therapy in acute myeloid leukemia

活性氧及其在急性髓系白血病发病机制和耐药性中的作用

Khorashad, Jamshid Sorouri; Rizzo, Sian; Tonks, Alex

Crosstalk between β-catenin and WT1 signaling activity in acute myeloid leukemia

急性髓系白血病中β-catenin和WT1信号活性之间的相互作用

Wagstaff, Megan; Tsaponina, Olga; Caalim, Gilian; Greenfield, Hayley; Milton-Harris, Leanne; Mancini, Erika J; Blair, Allison; Heesom, Kate J; Tonks, Alex; Darley, Richard L; Roberts, Stefan G; Morgan, Rhys G

CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis.

CD200胞外域脱落到肿瘤微环境中会导致NK细胞功能障碍和凋亡

Morgan Huw J, Rees Elise, Lanfredini Simone, Powell Kate A, Gore Jasmine, Gibbs Alex, Lovatt Charlotte, Davies Gemma E, Olivero Carlotta, Shorning Boris Y, Tornillo Giusy, Tonks Alex, Darley Richard, Wang Eddie Cy, Patel Girish K

Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux

蛋白激酶Cε过度表达与急性髓系白血病患者预后不良相关,并通过P-糖蛋白介导的药物外排促进柔红霉素耐药。

Nicholson, Rachael; Menezes, Ana Catarina; Azevedo, Aleksandra; Leckenby, Adam; Davies, Sara; Seedhouse, Claire; Gilkes, Amanda; Knapper, Steve; Tonks, Alex; Darley, Richard L

Gata2 haploinsufficiency promotes proliferation and functional decline of hematopoietic stem cells with myeloid bias during aging

Gata2单倍体不足会促进衰老过程中具有髓系偏向性的造血干细胞的增殖和功能衰退。

Abdelfattah, Ali; Hughes-Davies, Antonia; Clayfield, Liam; Menendez-Gonzalez, Juan Bautista; Almotiri, Alhomidi; Alotaibi, Badi; Tonks, Alex; Rodrigues, Neil P

Use of an anti-CD200-blocking antibody improves immune responses to AML in vitro and in vivo

使用抗CD200阻断抗体可改善体外和体内针对急性髓系白血病(AML)的免疫反应。

Rastogi, Namrata; Baker, Sarah; Man, Stephen; Uger, Robert A; Wong, Mark; Coles, Steven J; Hodges, Marie; Gilkes, Amanda F; Knapper, Steven; Darley, Richard L; Tonks, Alex

Make Your Cake and Eat It: Refueling of Immune Fitness in AML Post Allo-HCT Using Baking Soda

鱼与熊掌兼得:利用小苏打恢复异基因造血干细胞移植后急性髓系白血病患者的免疫功能

Tonks, Alex

Reactive oxygen species in leukemias: maintaining cancer cell proliferation via redox signaling and changing metabolic homeostasis

白血病中的活性氧:通过氧化还原信号传导和改变代谢稳态维持癌细胞增殖

Robinson, Andrew J; Darley, Richard L; Tonks, Alex

Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3

活性氧通过糖酵解调节因子PFKFB3驱动急性髓系白血病细胞增殖

Robinson, Andrew J; Hopkins, Goitseone L; Rastogi, Namrata; Hodges, Marie; Doyle, Michelle; Davies, Sara; Hole, Paul S; Omidvar, Nader; Darley, Richard L; Tonks, Alex