日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Identification and biological evaluation of benzimidazole-based compounds as novel TGFβR1 inhibitors

鉴定和生物学评价苯并咪唑类化合物作为新型TGFβR1抑制剂

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2600746
Tseng, Hui-Ju; Wu, Yi-Wen; Chen, Yan-Ling; Lin, Tony Eight; Fang-Chin, Yu-Ting; Wu, Yueh-Lin; Sung, Tzu-Ying; Yen, Shih-Chung; Hsieh, Jui-Hua; Hsu, Kai-Cheng; Pan, Shiow-Lin
TGFβ
发表日期：2026
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Consensus Pharmacological Interactions for PLK2 Inhibitor Identification in Colorectal Cancer Treatment

结直肠癌治疗中PLK2抑制剂鉴定的共识药理学相互作用

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.5c02197
Wu, Yi-Wen; Yang, Chun-Lin; Lin, Tony Eight; Yeh, Yun-Hsuan; Fang-Chin, Yu-Ting; Sung, Tzu-Ying; Yen, Shih-Chung; Hsieh, Jui-Hua; Chung, Cheng-Chih; Pan, Shiow-Lin; Hsu, Kai-Cheng
肿瘤
肠癌
肿瘤免疫
发表日期：2026
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Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure-Based Virtual Screening.

利用基于结构的虚拟筛选方法鉴定和生物学评价一种靶向胰腺癌中选择性剪接的新型 CLK4 抑制剂

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202416323
Yang Chun-Lin, Wu Yi-Wen, Tu Huang-Ju, Yeh Yun-Hsuan, Lin Tony Eight, Sung Tzu-Ying, Li Mu-Chun, Yen Shih-Chung, Hsieh Jui-Hua, Yu Ming-Chin, Hsieh Sen-Yung, Hsieh Hsing-Pang, Pan Shiow-Lin, Hsu Kai-Cheng
肿瘤
胰腺癌
发表日期：2025
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The Cyclin-Dependent Kinase 8 Inhibitor E966-0530-45418 Attenuates Pulmonary Fibrosis In Vitro and In Vivo

细胞周期蛋白依赖性激酶8抑制剂E966-0530-45418在体外和体内均能减轻肺纤维化

期刊:International Journal of Biological Sciences
影响因子:8.2
doi:10.7150/ijbs.105826
Ching-Hsuan Chou,Wei-Jan Huang,Kai-Cheng Hsu,Jui-Yi Hsu,Tony Eight Lin,Chia-Ron Yang
细胞生物学
发表日期：2025
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Exploring diarylheptanoid derivatives to target LIMK1 as potential agents against colorectal cancer

探索以LIMK1为靶点的二芳基庚烷衍生物作为潜在的结直肠癌治疗药物

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.4
doi:10.1080/14756366.2025.2583826
Chen, Liang-Chieh; Chang, Tung-Cheng; Tseng, Hui-Ju; Chu, Jung-Chun; Huang, Yun-Yi; Peng, Hao-Yuan; Kuo, Yi-Chen; Wu, Yi-Wen; Lin, Tony Eight; Yen, Shih-Chung; Hsu, Kai-Cheng; Huang, Wei-Jan; Pan, Shiow-Lin
肿瘤
肠癌
肿瘤免疫
LIMK1
发表日期：2025
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Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening

利用基于结构的虚拟筛选鉴定高效 CDK8 抑制剂

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.4c02011
Lin, Tony Eight; Chou, Ching-Hsuan; Wu, Yi-Wen; Sung, Tzu-Ying; Hsu, Jui-Yi; Yen, Shih-Chung; Hsieh, Jui-Hua; Chang, Yu-Wei; Pan, Shiow-Lin; Huang, Wei-Jan; Hsu, Kai-Cheng; Yang, Chia-Ron
CDK8
发表日期：2025
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Establishment of an Integrated Model for Predicting Compound Mutagenicity with a Feature Importance Analysis

基于特征重要性分析的化合物致突变性预测综合模型的建立

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.5c01586
Yang, Chao-Hsu; Lin, Tony Eight; Hsieh, Jui-Hua; Hsu, Kai-Cheng; Chiueh, Pei-Te
毒理研究
发表日期：2025
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A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant Müller glia activation and oxidative stress

新型 HDAC8 抑制剂 H7E 通过改善异常 Müller 胶质细胞活化和氧化应激发挥对青光眼损伤的视网膜保护作用

期刊:Biomedicine & Pharmacotherapy
影响因子:6.9
doi:10.1016/j.biopha.2024.116538
Liang-Huan Wu, Yu-Wen Cheng, Fan-Li Lin, Kai-Cheng Hsu, Mong-Heng Wang, Jing-Lun Yen, Tsung-Jen Wang, Tony Eight Lin, Yi-Chien Liu, Wei-Jan Huang, George Hsiao
细胞生物学
胶质细胞
发表日期：2024
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Discovering a novel dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitor and its impact on tau phosphorylation and amyloid-β formation

发现一种新型双特异性酪氨酸磷酸化调节激酶1A (DYRK1A) 抑制剂及其对tau蛋白磷酸化和β-淀粉样蛋白形成的影响

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.6
doi:10.1080/14756366.2024.2418470
Huang-Ju Tu ，Min-Wu Chao ，Cheng-Chung Lee ，Chao-Shiang Peng ，Yi-Wen Wu ，Tony Eight Lin ，Yu-Wei Chang ，Shih-Chung Yen ，Kai-Cheng Hsu ，Shiow-Lin Pan ，Wei-Chun HuangFu
DYR
磷酸化
DYRK1A
信号转导
发表日期：2024
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Synthesis and biological evaluation of ortho-phenyl phenylhydroxamic acids containing phenothiazine with improved selectivity for class IIa histone deacetylases

含吩噻嗪的邻苯基苯异羟肟酸的合成及生物学评价，以提高对 IIa 类组蛋白去乙酰化酶的选择性

期刊:Journal of Enzyme Inhibition and Medicinal Chemistry
影响因子:5.6
doi:10.1080/14756366.2024.2406025
Kai-Cheng Hsu, Yun-Yi Huang, Jung-Chun Chu, Yu-Wen Huang, Jing-Lan Hu, Tony Eight Lin, Shih-Chung Yen, Jing-Ru Weng, Wei-Jan Huang
表观遗传
发表日期：2024
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