日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dynamic Behavior and Substrate Interactions of the Polymyxin Resistance Determinant MCR-1 Investigated by Molecular Dynamics Simulations in the Membrane Environment

利用分子动力学模拟研究膜环境中多粘菌素耐药决定簇MCR-1的动态行为和底物相互作用

Lythell, Emily; Badley, Jack; Suardíaz, Reynier; Gurr, Catherine R; Tooke, Catherine L; Hinchliffe, Philip; Oliveira, A Sofia F; Van der Kamp, Marc W; Spencer, James; Mulholland, Adrian J

Mechanistic basis for inhibition of the extended-spectrum β-lactamase GES-1 by enmetazobactam and tazobactam

恩美他唑巴坦和他唑巴坦抑制超广谱β-内酰胺酶GES-1的机制基础

Beer, Michael; Hinchliffe, Philip; Hanževački, Marko; Bethel, Christopher R; Tooke, Catherine L; Van der Kamp, Marc W; Papp-Wallace, Krisztina M; Bonomo, Robert A; Shapiro, Stuart; Mulholland, Adrian J; Spencer, James

Dynamical responses predict a distal site that modulates activity in an antibiotic resistance enzyme

动态响应预测远端位点能够调节抗生素耐药酶的活性。

Beer, Michael; Oliveira, Ana Sofia F; Tooke, Catherine L; Hinchliffe, Philip; Tsz Yan Li, Angie; Balega, Balazs; Spencer, James; Mulholland, Adrian J

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

比阿培南与VIM金属β-内酰胺酶和丝氨酸β-内酰胺酶KPC-2反应的研究

Lucic, Anka; Malla, Tika R; Calvopiña, Karina; Tooke, Catherine L; Brem, Jürgen; McDonough, Michael A; Spencer, James; Schofield, Christopher J

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography.

一种利用连续晶体学方法研究酶催化的按需逐滴法

Butryn Agata, Simon Philipp S, Aller Pierre, Hinchliffe Philip, Massad Ramzi N, Leen Gabriel, Tooke Catherine L, Bogacz Isabel, Kim In-Sik, Bhowmick Asmit, Brewster Aaron S, Devenish Nicholas E, Brem Jürgen, Kamps Jos J A G, Lang Pauline A, Rabe Patrick, Axford Danny, Beale John H, Davy Bradley, Ebrahim Ali, Orlans Julien, Storm Selina L S, Zhou Tiankun, Owada Shigeki, Tanaka Rie, Tono Kensuke, Evans Gwyndaf, Owen Robin L, Houle Frances A, Sauter Nicholas K, Schofield Christopher J, Spencer James, Yachandra Vittal K, Yano Junko, Kern Jan F, Orville Allen M

Allosteric communication in class A β-lactamases occurs via cooperative coupling of loop dynamics

A类β-内酰胺酶的变构通讯是通过环动力学的协同耦合实现的。

Galdadas, Ioannis; Qu, Shen; Oliveira, Ana Sofia F; Olehnovics, Edgar; Mack, Andrew R; Mojica, Maria F; Agarwal, Pratul K; Tooke, Catherine L; Gervasio, Francesco Luigi; Spencer, James; Bonomo, Robert A; Mulholland, Adrian J; Haider, Shozeb

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants

l,d-转肽酶和丝氨酸β-内酰胺酶半胱氨酸变体对非水解性β-内酰胺类抗生素的片段化作用

Lohans, Christopher T; Chan, H T Henry; Malla, Tika R; Kumar, Kiran; Kamps, Jos J A G; McArdle, Darius J B; van Groesen, Emma; de Munnik, Mariska; Tooke, Catherine L; Spencer, James; Paton, Robert S; Brem, Jürgen; Schofield, Christopher J

β-Lactamases and β-Lactamase Inhibitors in the 21st Century

21世纪的β-内酰胺酶和β-内酰胺酶抑制剂

Tooke, Catherine L; Hinchliffe, Philip; Bragginton, Eilis C; Colenso, Charlotte K; Hirvonen, Viivi H A; Takebayashi, Yuiko; Spencer, James

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

瑞巴坦抑制A类β-内酰胺酶的分子机制

Tooke, Catherine L; Hinchliffe, Philip; Lang, Pauline A; Mulholland, Adrian J; Brem, Jürgen; Schofield, Christopher J; Spencer, James

Profiling interactions of vaborbactam with metallo-β-lactamases

分析vaborbactam与金属β-内酰胺酶的相互作用

Langley, Gareth W; Cain, Ricky; Tyrrell, Jonathan M; Hinchliffe, Philip; Calvopiña, Karina; Tooke, Catherine L; Widlake, Emma; Dowson, Christopher G; Spencer, James; Walsh, Timothy R; Schofield, Christopher J; Brem, Jürgen