日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Author Correction: Targeting the SHOC2-RAS interaction in RAS-mutant cancers

作者更正:靶向 RAS 突变癌症中的 SHOC2-RAS 相互作用

Hauseman, Zachary J; Stauffer, Frédéric; Beyer, Kim S; Mollé, Sandra; Cavicchioli, Elena; Marchand, Jean-Remy; Fodor, Michelle; Viscomi, Jessica; Dhembi, Anxhela; Katz, Stéphanie; Faggion, Beatrice; Lanter, Mylene; Kerr, Grainne; Schildknecht, Daniela; Handl, Cornelia; Maddalo, Danilo; Pissot Soldermann, Carole; Brady, Jacob; Shrestha, Om; Nguyen, Zachary; Leder, Lukas; Cremosnik, Gregor; Lopez Romero, Sandra; Hassiepen, Ulrich; Stams, Travis; Linder, Markus; Galli, Giorgio G; Guthy, Daniel A; King, Daniel A; Maira, Sauveur-Michel; Thoma, Claudio R; Ehmke, Veronika; Tordella, Luca

Targeting the SHOC2-RAS interaction in RAS-mutant cancers.

靶向 RAS 突变癌症中的 SHOC2-RAS 相互作用

Hauseman Zachary J, Stauffer Frédéric, Beyer Kim S, Mollé Sandra, Cavicchioli Elena, Marchand Jean-Remy, Fodor Michelle, Viscomi Jessica, Dhembi Anxhela, Katz Stéphanie, Faggion Beatrice, Lanter Mylene, Kerr Grainne, Schildknecht Daniela, Handl Cornelia, Maddalo Danilo, Pissot Soldermann Carole, Brady Jacob, Shrestha Om, Nguyen Zachary, Leder Lukas, Cremosnik Gregor, Lopez Romero Sandra, Hassiepen Ulrich, Stams Travis, Linder Markus, Galli Giorgio G, Guthy Daniel A, King Daniel A, Maira Sauveur-Michel, Thoma Claudio R, Ehmke Veronika, Tordella Luca

Identification and characterization of binders to a cryptic and functional pocket in KRAS

鉴定和表征KRAS中隐蔽功能口袋的结合蛋白

Beyer, Kim S; Klein, Jessica; Katz, Stéphanie; Welker, Patrick; Lanter, Mylene; Guthy, Daniel; Pollehn, Kerstin; Gluck-Gadé, Aurélie; Bleu, Melusine; Desogus, Jessica; Hattenberger, Marc; Borrello, Damiano; Abdul Rahman, Wassim; Zink, Florence; Ostermann, Nils; Jahnke, Wolfgang; Dumelin, Christoph E; Leder, Lukas; Esser, Oliver; Muller, Lionel; Marzinzik, Andreas; Cébé, Regis; Müller, Kathrin; Galli, Giorgio G; Tordella, Luca; Cotesta, Simona; Brachmann, Saskia M; Maira, Sauveur-Michel

Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers

IAG933通过直接和选择性地药理学手段破坏YAP-TEAD界面,从而抑制Hippo依赖性和RAS-MAPK改变的癌症。

Emilie A Chapeau ,Laurent Sansregret ,Giorgio G Galli ,Patrick Chène ,Markus Wartmann ,Thanos P Mourikis ,Patricia Jaaks ,Sabrina Baltschukat ,Ines A M Barbosa ,Daniel Bauer ,Saskia M Brachmann ,Clara Delaunay ,Claire Estadieu ,Jason E Faris ,Pascal Furet ,Stefanie Harlfinger ,Andreas Hueber ,Eloísa Jiménez Núñez ,David P Kodack ,Emeline Mandon ,Typhaine Martin ,Yannick Mesrouze ,Vincent Romanet ,Clemens Scheufler ,Holger Sellner ,Christelle Stamm ,Dario Sterker ,Luca Tordella ,Francesco Hofmann ,Nicolas Soldermann ,Tobias Schmelzle

Author Correction: DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance

作者更正:基于 DCAF1 的 PROTAC 具有针对临床验证靶点的活性,可克服内在和获得性降解剂耐药性。

Schröder, Martin; Renatus, Martin; Liang, Xiaoyou; Meili, Fabian; Zoller, Thomas; Ferrand, Sandrine; Gauter, Francois; Li, Xiaoyan; Sigoillot, Frederic; Gleim, Scott; Stachyra, Therese-Marie; Thomas, Jason R; Begue, Damien; Khoshouei, Maryam; Lefeuvre, Peggy; Andraos-Rey, Rita; Chung, BoYee; Ma, Renate; Pinch, Benika; Hofmann, Andreas; Schirle, Markus; Schmiedeberg, Niko; Imbach, Patricia; Gorses, Delphine; Calkins, Keith; Bauer-Probst, Beatrice; Maschlej, Magdalena; Niederst, Matt; Maher, Rob; Henault, Martin; Alford, John; Ahrne, Erik; Tordella, Luca; Hollingworth, Greg; Thomä, Nicolas H; Vulpetti, Anna; Radimerski, Thomas; Holzer, Philipp; Carbonneau, Seth; Thoma, Claudio R

Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens

通过大规模功能表观基因组筛选揭示 YAP 反应元件的癌症谱系特异性调控

Inês A M Barbosa, Rajaraman Gopalakrishnan, Samuele Mercan, Thanos P Mourikis, Typhaine Martin, Simon Wengert, Caibin Sheng, Fei Ji, Rui Lopes, Judith Knehr, Marc Altorfer, Alicia Lindeman, Carsten Russ, Ulrike Naumann, Javad Golji, Kathleen Sprouffske, Louise Barys, Luca Tordella, Dirk Schübeler, T

CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung Cancer

CRISPR 筛选确定了非小细胞肺癌对 KRASG12C 和 SHP2 抑制剂组合的耐药机制

Anirudh Prahallad #, Andreas Weiss #, Hans Voshol, Grainne Kerr, Kathleen Sprouffske, Tina Yuan, David Ruddy, Morgane Meistertzheim, Malika Kazic-Legueux, Tina Kottarathil, Michelle Piquet, Yichen Cao, Laetitia Martinuzzi-Duboc, Alexandra Buhles, Flavia Adler, Salvatore Mannino, Luca Tordella, Laure

Structure of the MRAS-SHOC2-PP1C phosphatase complex

MRAS-SHOC2-PP1C磷酸酶复合物的结构

Zachary J Hauseman #,Michelle Fodor #,Anxhela Dhembi,Jessica Viscomi,David Egli,Melusine Bleu,Stephanie Katz,Eunyoung Park,Dong Man Jang,Kathryn A Porter,Fabian Meili,Hongqiu Guo,Grainne Kerr,Sandra Mollé,Camilo Velez-Vega,Kim S Beyer,Giorgio G Galli,Saveur-Michel Maira,Travis Stams,Kirk Clark,Michael J Eck,Luca Tordella,Claudio R Thoma,Daniel A King

Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms

靶向 ASNS 联合 l-天冬酰胺酶治疗实体肿瘤的疗效评估及耐药机制研究

Verena Apfel, Damien Begue, Valentina Cordo', Laura Holzer, Laetitia Martinuzzi, Alexandra Buhles, Grainne Kerr, Ines Barbosa, Ulrike Naumann, Michelle Piquet, David Ruddy, Andreas Weiss, Stephane Ferretti, Reinaldo Almeida, Debora Bonenfant, Luca Tordella, Giorgio G Galli

PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

PAX8 通过增强子元件激活肾细胞癌中的代谢基因

Melusine Bleu, Swann Gaulis, Rui Lopes, Kathleen Sprouffske, Verena Apfel, Sjoerd Holwerda, Marco Pregnolato, Umut Yildiz, Valentina Cordoʹ, Antonella F M Dost, Judith Knehr, Walter Carbone, Felix Lohmann, Charles Y Lin, James E Bradner, Audrey Kauffmann, Luca Tordella, Guglielmo Roma, Giorgio G Gal