Spot 14 protein interacts and co-operates with chicken ovalbumin upstream promoter-transcription factor 1 in the transcription of the L-type pyruvate kinase gene through a specificity protein 1 (Sp1) binding site.

Spot 14 蛋白通过特异性蛋白 1 (Sp1) 结合位点与鸡卵清蛋白上游启动子转录因子 1 相互作用并协同作用，从而转录 L 型丙酮酸激酶基因