Toth Eric A相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design.

天然可溶性 E1E2 糖蛋白异二聚体在自组装蛋白纳米颗粒上的应用，用于丙型肝炎病毒疫苗设计。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-026-69418-9

He Linling, Lee Yi-Zong, Zhang Yi-Nan, Newby Maddy L, Janus Benjamin M, Gonzalez Fabrizio G, Ward Garrett, DesRoberts Connor, Hung Shr-Hau, Giang Erick, Allen Joel D, Kulakova Liudmila, Toth Eric A, Fuerst Thomas R, Law Mansun, Ofek Gilad, Crispin Max, Zhu Jiang

发表日期：2026

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Substrate specificity in a designed RAS-targeting protease is coupled to active site and distal motions

设计的RAS靶向蛋白酶的底物特异性与活性位点和远端运动相关。

doi:10.64898/2026.01.15.699477

Chu, Betty; He, Yanan; Chen, Yihong; Toth, Eric A; Orban, John

发表日期：2026

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mAbClust with AlphaFold 3 avoids hallucinations to define a quaternary broadly neutralizing HCV epitope

mAbClust 结合 AlphaFold 3 可避免产生幻觉，从而确定一个广谱中和 HCV 表位的四级结构。

doi:10.64898/2026.01.06.698032

Paul, Harry T; Mimms, Jessica L; Aboueid, Hanna; Buitrago, Laura Sanchez; Kulakova, Liudmila; Wilcox, Xander; Kuhn, Katrina; Zhang, Hao; Toth, Eric A; Skinner, Nicole; Flyak, Andrew I; Ofek, Gilad; Benjamin Larman, H; Fuerst, Thomas R; Ray, Stuart C; Cox, Andrea L; Bailey, Justin R

发表日期：2026

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Virus-Mimicking Polymer Nanocomplexes Co-Assembling HCV E1E2 and Core Proteins with TLR 7/8 Agonist-Synthesis, Characterization, and In Vivo Activity

病毒模拟聚合物纳米复合物与 TLR 7/8 激动剂共组装 HCV E1E2 和核心蛋白——合成、表征及体内活性

期刊:Journal of Functional Biomaterials

影响因子:5.2

doi:10.3390/jfb16010034

Fuerst, Thomas R; Marin, Alexander; Jeong, Sarah; Kulakova, Liudmila; Hlushko, Raman; Gorga, Katrina; Toth, Eric A; Singh, Nevil J; Andrianov, Alexander K

发表日期：2025

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Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.

利用二价 Fab 作为参考标记，确定了 HCV E2 糖蛋白与中和抗体和非中和抗体结合的冷冻电镜结构

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-025-08239-w

Shahid Salman, Karade Sharanbasappa S, Hasan S Saif, Yin Rui, Jiang Liqun, Liu Yanxin, Felbinger Nathaniel, Kulakova Liudmila, Toth Eric A, Keck Zhen-Yong, Foung Steven K H, Fuerst Thomas R, Pierce Brian G, Mariuzza Roy A

免疫/内分泌

发表日期：2025

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Polyphosphazene-Mediated Assembly of TLR4 and TLR7/8 Agonists Enables a Potent Nano-Adjuvant Delivery System for Hepatitis C Virus Vaccine Antigens

聚磷腈介导的TLR4和TLR7/8激动剂组装可实现丙型肝炎病毒疫苗抗原的高效纳米佐剂递送系统

期刊:Vaccines

影响因子:3.4

doi:10.3390/vaccines13101012

Andrianov, Alexander K; Marin, Alexander; Jeong, Sarah; Kulakova, Liudmila; Chowdhury, Ananda; Hlushko, Raman; Das, Sayan; Moy, Francesca; Toth, Eric A; Ernst, Robert K; Fuerst, Thomas R

发表日期：2025

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Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity

丙型肝炎病毒E2糖蛋白的糖基化工程改造可改善其生化特性并增强其免疫原性

doi:10.1101/2025.04.02.646860

Kulakova, Liudmila; Li, Kiki H; Chiang, Austin W T; Schwoerer, Michael P; Schoffelen, Sanne; Elkholy, Khadija; Chao, Kinlin L; Shahid, Salman; Kumar, Bhoj; Murray, Nathan B; Archer-Hartmann, Stephanie; Azadi, Parastoo; Voldborg, Bjørn G; Marin, Alexander; Mariuzza, Roy A; Andrianov, Alexander K; Ploss, Alexander; Lewis, Nathan E; Toth, Eric A; Fuerst, Thomas R

免疫/内分泌

发表日期：2025

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Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design

用于丙型肝炎病毒疫苗设计的天然可溶性E1E2糖蛋白异二聚体在自组装蛋白纳米颗粒上的应用

doi:10.1101/2025.05.16.654559

He, Linling; Lee, Yi-Zong; Zhang, Yi-Nan; Newby, Maddy L; Janus, Benjamin M; Gonzalez, Fabrizio G; Ward, Garrett; DesRoberts, Connor; Hung, Shr-Hau; Giang, Erick; Allen, Joel D; Kulakova, Liudmila; Toth, Eric A; Fuerst, Thomas R; Law, Mansun; Ofek, Gilad; Crispin, Max; Zhu, Jiang

发表日期：2025

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B cell transcriptomics reveals lasting dysregulation and rapid decline of protective memory after hepatitis C cure

B细胞转录组学研究揭示丙型肝炎治愈后保护性记忆的持续失调和快速衰退

doi:10.1101/2025.10.24.664545

Chen, Fang; Giang, Erick; Natarajan, Padmaja; Mondala, Tony S; Head, Steven R; Lau, Sing Chau; Sundaresan, Aishwarya; Kulakova, Liudmila; Lin, Xiaohe; Aneja, Jasneet; Andrabi, Raiees; Zhang, Yun; Scheuermann, Richard H; Toth, Eric A; Fuerst, Thomas R; Lewis-Ximenez, Lia; Kim, Arthur Y; Pockros, Paul; Lauer, Georg M; Law, Mansun

细胞生物学

免疫/内分泌

发表日期：2025

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Enhanced Production of HCV E1E2 Subunit Vaccine Candidates via Protein-Protein Interaction Identification in Glycoengineered CHO cells.

通过糖基工程化 CHO 细胞中蛋白质-蛋白质相互作用鉴定增强 HCV E1E2 亚单位疫苗候选物的产量

doi:10.1101/2025.05.20.655202

Wu Mina Ying Min, Rocamora Frances, Robinson Caressa M, Shin Seunghyeon, Toth Eric A, Fuerst Thomas R, Maurya Svetlana, Lewis Nathan E

细胞生物学

发表日期：2025

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