日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multi-omic analysis of SDHB-deficient pheochromocytomas and paragangliomas identifies metastasis and treatment-related molecular profiles.

对 SDHB 缺乏型嗜铬细胞瘤和副神经节瘤进行多组学分析,可识别转移和治疗相关的分子特征

Flynn Aidan, Pattison Andrew D, Balachander Shiva, Boehm Emma, Bowen Blake, Dwight Trisha, Rossello Fernando J, Hofmann Oliver, Martelotto Luciano, Zethoven Maia, Kirschner Lawrence S, Else Tobias, Fishbein Lauren, Gill Anthony J, Tischler Arthur S, Giordano Thomas, Prodanov Tamara, Noble Jane R, Reddel Roger R, Trainer Alison H, Ghayee Hans Kumar, Bourdeau Isabelle, Elston Marianne, Ishak Diana, Ngeow Yuen Yie Joanne, Hicks Rodney J, Crona Joakim, à kerström Tobias, Stålberg Peter, Dahia Patricia, Grimmond Sean, Clifton-Bligh Roderick, Pacak Karel, Tothill Richard W

Whole genome sequencing improves tissue-of-origin diagnosis and treatment options for cancer of unknown primary

全基因组测序可改善原发灶不明癌症的组织来源诊断和治疗选择。

Richard J Rebello # ,Atara Posner # ,Ruining Dong ,Owen W J Prall ,Tharani Sivakumaran ,Camilla B Mitchell ,Aidan Flynn ,Alex Caneborg ,Catherine Mitchell ,Sehrish Kanwal ,Clare Fedele ,Samantha Webb ,Krista Fisher ,Hui-Li Wong ,Shiva Balachander ,Wenying Zhu ,Shannon Nicolson ,Voula Dimitriadis ,Nicholas Wilcken ,Anna DeFazio ,Bo Gao ,Madhu Singh ,Ian M Collins ,Christopher Steer ,Mark Warren ,Narayan Karanth ,Huiling Xu ,Andrew Fellowes ,Rodney J Hicks ,Kym Pham Stewart ,Charles Shale ,Peter Priestley ,Sarah-Jane Dawson ,Joseph H A Vissers ,Stephen B Fox ,Penelope Schofield ,David Bowtell ,Oliver Hofmann ,Sean M Grimmond ,Linda Mileshkin ,Richard W Tothill

Pathologist-initiated whole genome and transcriptome sequencing demonstrates diagnostic utility in resolving difficult-to-diagnose tumors

病理学家发起的全基因组和转录组测序在解决疑难肿瘤诊断方面展现出诊断价值

Vissers, Joseph H A; Mitchell, Catherine; Prall, Owen W J; Lo, Wing-Yee; Kanwal, Sehrish; Luen, Stephen J; Watts, Stephen C; Angel, Christopher M; Khoo, Christine; Pang, Jia-Min B; Murray, William K; Snell, Cameron; Christie, Michael; Rebello, Richard J; Tothill, Richard W; Pham, Kym; Hofmann, Oliver; Fox, Stephen B; Grimmond, Sean M

Solving unknown primary cancer with earlier diagnosis - the SUPER-ED trial: study protocol for a stepped-wedge cluster randomised controlled trial to support earlier diagnosis for people presenting with malignancy of undefined primary origin

通过早期诊断解决原发灶不明癌症难题——SUPER-ED试验:一项阶梯楔形整群随机对照试验的研究方案,旨在支持对原发灶不明恶性肿瘤患者进行早期诊断

Ugalde, Anna; Tothill, Richard W; Quinn, Stephen; Wong, Hui-Li; Prall, Owen; Mitchell, Catherine; Wickramasinghe, Nilmini; Fedele, Clare; Richards, Natalie; Todio, Elizabeth; Bryant, Cindy; Collins, Louisa G; McLean, Sarah; Ko, Hyun Soo; Akhurst, Tim; Steer, Christopher; Gao, Bo; Wong, Mark; Georgiou, Chloe; Karanth, Narayan; Kuchel, Anna; Nott, Louise; Padinharakam, Shamsudheen; Shackleton, Mark; Collins, Ian M; Singh, Madhu; Wong, Rachel; Wong, Zee Wan; Butler, Alexis; Sivakumaran, Tharani; Schofield, Penelope; Mileshkin, Linda

Unravelling mutational signatures with plasma circulating tumour DNA

利用血浆循环肿瘤DNA揭示突变特征

Hollizeck, Sebastian; Wang, Ning; Wong, Stephen Q; Litchfield, Cassandra; Guinto, Jerick; Ftouni, Sarah; Rebello, Richard; Kanwal, Sehrish; Dong, Ruining; Grimmond, Sean; Sandhu, Shahneen; Mileshkin, Linda; Tothill, Richard W; Chandrananda, Dineika; Dawson, Sarah-Jane

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins

癌症中后生动物基因调控网络的破坏会改变单细胞和多细胞起源基因之间的共表达平衡。

Trigos, Anna S; Bongiovanni, Felicia; Zhang, Yangyi; Zethoven, Maia; Tothill, Richard; Pearson, Richard; Papenfuss, Anthony T; Goode, David L

A genome-wide CRISPR/Cas9 screen identifies DNA-PK as a sensitiser to 177Lutetium-DOTA-octreotate radionuclide therapy

全基因组 CRISPR/Cas9 筛选确定 DNA-PK 是 177Lutetium-DOTA-octreotate 放射性核素治疗的敏感剂

Kelly Waldeck, Jessica Van Zuylekom, Carleen Cullinane, Twishi Gulati, Kaylene J Simpson, Richard W Tothill, Benjamin Blyth, Rodney J Hicks

Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary

原发灶不明癌症免疫治疗反应的免疫和基因组生物标志物

Posner, Atara; Sivakumaran, Tharani; Pattison, Andrew; Etemadmoghadam, Dariush; Thio, Niko; Wood, Colin; Fisher, Krista; Webb, Samantha; DeFazio, Anna; Wilcken, Nicholas; Gao, Bo; Karapetis, Christos S; Singh, Madhu; Collins, Ian M; Richardson, Gary; Steer, Christopher; Warren, Mark; Karanth, Narayan; Fellowes, Andrew; Fox, Stephen B; Hicks, Rodney J; Schofield, Penelope; Bowtell, David; Prall, Owen W J; Tothill, Richard William; Mileshkin, Linda

Baseline mutational profiles of patients with carcinoma of unknown primary origin enrolled in the CUPISCO study

CUPISCO 研究中纳入的原发灶不明癌患者的基线突变谱

Westphalen, C B; Federer-Gsponer, J; Pauli, C; Karapetyan, A R; Chalabi, N; Durán-Pacheco, G; Beringer, A; Bochtler, T; Cook, N; Höglander, E; Jin, D X; Losa, F; Mileshkin, L; Moch, H; Ross, J S; Sokol, E S; Tothill, R W; Krämer, A

Australian Genomics: Outcomes of a 5-year national program to accelerate the integration of genomics in healthcare

澳大利亚基因组学:一项旨在加速基因组学融入医疗保健的五年国家计划的成果

Stark, Zornitza; Boughtwood, Tiffany; Haas, Matilda; Braithwaite, Jeffrey; Gaff, Clara L; Goranitis, Ilias; Spurdle, Amanda B; Hansen, David P; Hofmann, Oliver; Laing, Nigel; Metcalfe, Sylvia; Newson, Ainsley J; Scott, Hamish S; Thorne, Natalie; Ward, Robyn L; Dinger, Marcel E; Best, Stephanie; Long, Janet C; Grimmond, Sean M; Pearson, John; Waddell, Nicola; Barnett, Christopher P; Cook, Matthew; Field, Michael; Fielding, David; Fox, Stephen B; Gecz, Jozef; Jaffe, Adam; Leventer, Richard J; Lockhart, Paul J; Lunke, Sebastian; Mallett, Andrew J; McGaughran, Julie; Mileshkin, Linda; Nones, Katia; Roscioli, Tony; Scheffer, Ingrid E; Semsarian, Christopher; Simons, Cas; Thomas, David M; Thorburn, David R; Tothill, Richard; White, Deborah; Dunwoodie, Sally; Simpson, Peter T; Phillips, Peta; Brion, Marie-Jo; Finlay, Keri; Quinn, Michael Cj; Mattiske, Tessa; Tudini, Emma; Boggs, Kirsten; Murray, Sean; Wells, Kathy; Cannings, John; Sinclair, Andrew H; Christodoulou, John; North, Kathryn N