日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Novel GPU Engines for Virtual Screening of Giga-Sized Libraries Identify Inhibitors of Challenging Targets

用于对千兆级化合物库进行虚拟筛选的新型GPU引擎，可识别出具有挑战性靶点的抑制剂

期刊:Journal of Chemical Information and Modeling
影响因子:5.3
doi:10.1021/acs.jcim.5c01335
Raush, Eugene; Totrov, Maxim; Hoop, Cody L; Knowlan, Kevin M; Bianchi, Remington; Tarasova, Nadya I
发表日期：2025
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Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant Plasmodium falciparum

β-咔啉衍生物的表征揭示了其对环状体和DHA诱导的休眠期恶性疟原虫具有高抗药性屏障和强效活性。

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.5c00714
Haney, Reagan S; Butler, Joshua H; Wardlaw, Lyric A; Merino, Emilio F; Mendiola, Victoria; Cooper, Caitlin A; Mathew, Jopaul; Tumwebaze, Patrick K; Rosenthal, Philip J; Cooper, Roland A; Kyle, Dennis E; Rizopoulos, Zaira; Baud, Delphine; Brand, Stephen; Totrov, Maxim; Carlier, Paul R; Cassera, Maria Belen
发表日期：2025
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Stereospecific Resistance to N2-Acyl Tetrahydro-β-carboline Antimalarials Is Mediated by a PfMDR1 Mutation That Confers Collateral Drug Sensitivity

对N2-酰基四氢-β-咔啉类抗疟药的立体特异性耐药性是由PfMDR1突变介导的，该突变赋予了药物的附带敏感性。

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.4c01001
Bremers, Emily K; Butler, Joshua H; Do Amaral, Leticia S; Merino, Emilio F; Almolhim, Hanan; Zhou, Bo; Baptista, Rodrigo P; Totrov, Maxim; Carlier, Paul R; Cassera, Maria Belen
发表日期：2025
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Benzo-ring modification on Malaria Box hit MMV008138: effects on antimalarial potency and microsomal stability

疟疾靶点 MMV008138 的苯并环修饰：对抗疟疾效力和微粒体稳定性的影响

期刊:RSC Medicinal Chemistry
影响因子:3.6
doi:10.1039/d5md00439j
Ghavami, Maryam; Li, Haibo; Liu, Lixuan; Butler, Joshua H; Ding, Sha; Butschek, Grant J; Haney, Reagan S; Council-Troche, R McAlister; Grams, R Justin; Merino, Emilio F; Davis, Jennifer M; Totrov, Maxim; Cassera, Maria B; Carlier, Paul R
微生物学
多发性骨髓瘤
疟疾
发表日期：2025
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β-Carboline-3-carboxamide Antimalarials: Structure-Activity Relationship, ADME-Tox Studies, and Resistance Profiling

β-咔啉-3-甲酰胺类抗疟药：构效关系、ADME-Tox研究及耐药性分析

期刊:ACS Infectious Diseases
影响因子:3.8
doi:10.1021/acsinfecdis.4c00653
Mathew, Jopaul; Zhou, Bo; Haney, Reagan S; Kunz, Kevin A; Do Amaral, Leticia S; Roy Chowdhury, Rudraneel; Butler, Joshua H; Li, Haibo; Chakraborty, Amarraj J; Tabassum, Anika; Bremers, Emily K; Merino, Emilio F; Coyle, Rachael; Lee, Marcus C S; Baud, Delphine; Brand, Stephen; Totrov, Maxim; Cassera, Maria Belen; Carlier, Paul R
发表日期：2024
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Corrigendum: Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1

更正：免疫复合物疫苗接种可调节针对 HIV-1 的功能性抗体的诱导。

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2023.1329069
Hioe, Catarina E; Liu, Xiaomei; Banin, Andrew N; Heindel, Daniel W; Klingler, Je Romine; Rao, Priyanka G; Luo, Christina C; Jiang, Xunqing; Pandey, Shilpi; Ordonez, Tracy; Barnette, Philip; Totrov, Maxim; Zhu, Jiang; Na das, Arthur; Zolla-Pazner, Susan; Upadhyay, Chitra; Shen, Xiaoying; Kong, Xiang-Peng; Hessell, Ann J
HIV
免疫/内分泌
微生物学
发表日期：2023
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Vaccination with immune complexes modulates the elicitation of functional antibodies against HIV-1.

用免疫复合物进行疫苗接种可以调节针对 HIV-1 的功能性抗体的诱导

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2023.1271686
Hioe Catarina E, Liu Xiaomei, Banin Andrew N, Heindel Daniel W, Klingler Jéromine, Rao Priyanka G, Luo Christina C, Jiang Xunqing, Pandey Shilpi, Ordonez Tracy, Barnette Philip, Totrov Maxim, Zhu Jiang, Nádas Arthur, Zolla-Pazner Susan, Upadhyay Chitra, Shen Xiaoying, Kong Xiang-Peng, Hessell Ann J
免疫/内分泌
发表日期：2023
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New boronate drugs and evolving NDM-mediated beta-lactam resistance

新型硼酸酯类药物和不断演变的NDM介导的β-内酰胺类耐药性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/aac.00579-23
Lomovskaya, Olga; Tsivkovski, Ruslan; Totrov, Maxim; Dressel, Dana; Castanheira, Mariana; Dudley, Michael
发表日期：2023
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Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases

QPX7728 的生化特性研究：一种新型超广谱丝氨酸和金属β-内酰胺酶抑制剂

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00130-20
Tsivkovski, Ruslan; Totrov, Maxim; Lomovskaya, Olga
发表日期：2020
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Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

环状硼酸酯 QPX7728 是一种超广谱丝氨酸和金属β-内酰胺酶抑制剂，其对β-内酰胺酶的抑制谱具有显著的增强作用：增强多种抗生素对表达单一β-内酰胺酶的同源菌株的活性

期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.5
doi:10.1128/AAC.00212-20
Lomovskaya, Olga; Tsivkovski, Ruslan; Nelson, Kirk; Rubio-Aparicio, Debora; Sun, Dongxu; Totrov, Maxim; Dudley, Michael N
发表日期：2020
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