日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Drug- and Cell-Type-Specific Effects of ROCK Inhibitors as a Potential Cause of Reticular Corneal Epithelial Edema

ROCK抑制剂的药物和细胞类型特异性效应可能是网状角膜上皮水肿的潜在原因

期刊:Cells
影响因子:5.2
doi:10.3390/cells14040258
Schlötzer-Schrehardt, Ursula; Gießl, Andreas; Zenkel, Matthias; Bartsch, Alexander; Okumura, Naoki; Koizumi, Noriko; Kinoshita, Shigeru; Tourtas, Theofilos; Kruse, Friedrich E
细胞生物学
ROCK
发表日期：2025
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Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy

Emricasan（一种泛半胱天冬酶抑制剂）在减少 Fuchs 内皮角膜营养不良中的细胞死亡和细胞外基质积累方面的治疗潜力

期刊:Cells
影响因子:5.2
doi:10.3390/cells14070498
Fujimoto, Sohya; Endo, Mako; Tonomura, Shigehito; Tsuji, Fuuga; Haraguchi, Hirotaka; Hasegawa, Kanna; Numao, Taisuke; Izumi, Ayaka; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; Oyama, Yuki; Ikawa, Masahito; Jun, Albert S; Koizumi, Noriko; Okumura, Naoki
细胞生物学
发表日期：2025
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The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

TCF4基因调控Fuchs内皮角膜营养不良中角膜内皮细胞的凋亡

期刊:Investigative Ophthalmology & Visual Science
影响因子:4.7
doi:10.1167/iovs.66.3.16
Nakagawa, Tatsuya; Honda, Tetsuro; Yuasa, Taichi; Nishiuchi, Go; Sato, Masakazu; Tokunaga, Ayumi; Nakahara, Makiko; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; Padmanabhan, Prema; Chatterjee, Amit; Sathe, Gajanan; Ghose, Vivek; Janakiraman, Narayanan; Blake, Derek J; Koizumi, Noriko; Elchuri, Sailaja; Okumura, Naoki
凋亡
表观遗传
Apoptosis
信号转导
内皮细胞
细胞生物学
发表日期：2025
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The PERK-p38 MAPK Axis Drives Endoplasmic Reticulum Stress-Induced Apoptosis in Fuchs Endothelial Corneal Dystrophy

PERK-p38 MAPK轴驱动Fuchs内皮角膜营养不良中内质网应激诱导的细胞凋亡

期刊:Investigative Ophthalmology & Visual Science
影响因子:4.7
doi:10.1167/iovs.66.11.63
Onishi, Takako; Yuasa, Taichi; Ueda, Naoyuki; Miyadai, Keita; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; Koizumi, Noriko; Okumura, Naoki
凋亡
p38 MAPK
表观遗传
Apoptosis
内质网应激
MAPK/ERK
细胞生物学
PERK
发表日期：2025
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Protective Effects of Estradiol on Disease Progression in a Murine Model of Fuchs Endothelial Corneal Dystrophy

雌二醇对 Fuchs 内皮角膜营养不良小鼠模型疾病进展的保护作用

期刊:Investigative Ophthalmology & Visual Science
影响因子:4.7
doi:10.1167/iovs.66.15.64
Oka, Itsuki; Fujimoto, Sohya; Fukui, Tomohiro; Mayumi, Kota; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; Jun, Albert S; Koizumi, Noriko; Okumura, Naoki
发表日期：2025
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Comprehensive analysis of splicing variants in corneal endothelial cells of patients with Fuchs endothelial corneal dystrophy

对 Fuchs 内皮角膜营养不良患者角膜内皮细胞剪接变异体的综合分析

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-92119-0
Yuasa, Taichi; Tokuda, Yuichi; Nakano, Masakazu; Tashiro, Kei; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; Koizumi, Noriko; Okumura, Naoki
细胞生物学
内皮细胞
发表日期：2025
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A feasibility of computational drug screening for Fuchs endothelial corneal dystrophy

利用计算机辅助药物筛选治疗 Fuchs 内皮角膜营养不良的可行性

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-95003-z
Oka, Itsuki; Toyokawa, Yoshiaki; Imai, Kouta; Nakagawa, Tatsuya; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; Koizumi, Noriko; Okumura, Naoki
发表日期：2025
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Comprehensive identification of dysregulated extracellular matrix molecules in the corneal endothelium of patients with Fuchs endothelial corneal dystrophy.

对 Fuchs 内皮角膜营养不良患者角膜内皮细胞外基质分子失调进行全面鉴定

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-91850-y
Inagaki Soichiro, Vaitinadapoule Hanielle, Yuasa Taichi, Nakagawa Tatsuya, Ikegawa Masaya, Toyama Yumiko, Nirasawa Takashi, Tokuda Yuichi, Nakano Masakazu, Tashiro Kei, Tourtas Theofilos, Schlötzer-Schrehardt Ursula, Kruse Friedrich, Aouimeur Ines, He Zhiguo, Gain Philippe, Koizumi Noriko, Thuret Gilles, Okumura Naoki
细胞生物学
发表日期：2025
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Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

Fuchs内皮角膜营养不良患者角膜内皮细胞中TCF4亚型的失调

期刊:Investigative Ophthalmology & Visual Science
影响因子:4.7
doi:10.1167/iovs.65.6.27
Honda, Tetsuro; Nakagawa, Tatsuya; Yuasa, Taichi; Tokuda, Yuichi; Nakano, Masakazu; Tashiro, Kei; Tourtas, Theofilos; Schlötzer-Schrehardt, Ursula; Kruse, Friedrich; Yamamoto, Koji; Koizumi, Noriko; Okumura, Naoki
细胞生物学
内皮细胞
发表日期：2024
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Characterisation of ectasia after penetrating keratoplasty in keratoconus eyes using anterior segment optical coherence tomography

利用前节光学相干断层扫描对圆锥角膜眼穿透性角膜移植术后角膜扩张进行表征

期刊:British Journal of Ophthalmology
影响因子:3.5
doi:10.1136/bjo-2022-322859
Weller, Julia M; Hübner, Lisa; Kruse, Friedrich E; Tourtas, Theofilos
发表日期：2024
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