日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation

弥漫性大B细胞淋巴瘤的转录组分类识别出具有可靶向MYC失调的高危活化B细胞样亚群

Matthew E Stokes,Kerstin Wenzl,C Chris Huang,María Ortiz,Chih-Chao Hsu,Matthew J Maurer,Nicholas Stong,Yumi Nakayama,Lei Wu,Hsiling Chiu,Ann Polonskaia,Samuel A Danziger,Fadi Towfic,Joel Parker,Rebecca L King,Brian K Link,Susan L Slager,Vivekananda Sarangi,Yan W Asmann,Joseph P Novak,Akshay Sudhindra,Stephen M Ansell,Thomas M Habermann,Patrick R Hagner,Grzegorz S Nowakowski,James R Cerhan,Anne J Novak #,Anita K Gandhi #

Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma

全基因组分析揭示复发/难治性多发性骨髓瘤中的新驱动因素和高风险双重打击事件

Ansari-Pour, Naser; Samur, Mehmet; Flynt, Erin; Gooding, Sarah; Towfic, Fadi; Stong, Nicholas; Estevez, Maria Ortiz; Mavrommatis, Konstantinos; Walker, Brian; Morgan, Gareth; Munshi, Nikhil; Avet-Loiseau, Herve; Thakurta, Anjan

Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma

2q37位点COP9信号体基因的缺失与多发性骨髓瘤的IMiD耐药性相关

Gooding, Sarah; Ansari-Pour, Naser; Kazeroun, Mohammad; Karagoz, Kubra; Polonskaia, Ann; Salazar, Mirian; Fitzsimons, Evie; Sirinukunwattana, Korsuk; Chavda, Selina; Ortiz Estevez, Maria; Towfic, Fadi; Flynt, Erin; Pierceall, William; Royston, Daniel; Yong, Kwee; Ramasamy, Karthik; Vyas, Paresh; Thakurta, Anjan

Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL

Aiolos/Ikaros 相互作用组揭示了 Cereblon 调节剂与 HDAC 抑制剂在 DLBCL 中的联合应用原理

Patrick R Hagner, Hsiling Chiu, Vivek S Chopra, Martino Colombo, Nisha Patel, Maria Ortiz Estevez, Michelle F Waldman, Remco Loos, Fadi Towfic, Anita K Gandhi

Multiple Myeloma Patient Tumors With High Levels of Cereblon Exon-10 Deletion Splice Variant Upregulate Clinically Targetable Pro-Inflammatory Cytokine Pathways

多发性骨髓瘤患者肿瘤中高水平的Cereblon外显子10缺失剪接变体上调临床可靶向的促炎细胞因子通路

Karagoz, Kubra; Stokes, Matthew; Ortiz-Estévez, María; Towfic, Fadi; Flynt, Erin; Gooding, Sarah; Pierceall, William; Thakurta, Anjan

Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways

整合多组学分析发现,高风险多发性骨髓瘤亚组与显著的DNA丢失以及DNA修复和细胞周期通路失调相关。

Ortiz-Estévez, María; Towfic, Fadi; Flynt, Erin; Stong, Nicholas; Jang, In Sock; Wang, Kai; Trotter, Matthew W B; Thakurta, Anjan

Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN

伊比度胺 (CC-220) 是一种强效的 cereblon E3 连接酶调节剂,对 CRBN 失调的来那度胺和泊马度胺耐药的多发性骨髓瘤细胞具有抗肿瘤和免疫刺激活性。

Bjorklund, Chad C; Kang, Jian; Amatangelo, Michael; Polonskaia, Ann; Katz, Mark; Chiu, Hsiling; Couto, Suzana; Wang, Maria; Ren, Yan; Ortiz, Maria; Towfic, Fadi; Flynt, J Erin; Pierceall, William; Thakurta, Anjan

Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease

多发性骨髓瘤DREAM挑战赛揭示表观遗传调控因子PHF19是侵袭性疾病的标志物

Mason, Mike J; Schinke, Carolina; Eng, Christine L P; Towfic, Fadi; Gruber, Fred; Dervan, Andrew; White, Brian S; Pratapa, Aditya; Guan, Yuanfang; Chen, Hongjie; Cui, Yi; Li, Bailiang; Yu, Thomas; Chaibub Neto, Elias; Mavrommatis, Konstantinos; Ortiz, Maria; Lyzogubov, Valeriy; Bisht, Kamlesh; Dai, Hongyue Y; Schmitz, Frank; Flynt, Erin; Dan Rozelle; Danziger, Samuel A; Ratushny, Alexander; Dalton, William S; Goldschmidt, Hartmut; Avet-Loiseau, Herve; Samur, Mehmet; Hayete, Boris; Sonneveld, Pieter; Shain, Kenneth H; Munshi, Nikhil; Auclair, Daniel; Hose, Dirk; Morgan, Gareth; Trotter, Matthew; Bassett, Douglas; Goke, Jonathan; Walker, Brian A; Thakurta, Anjan; Guinney, Justin

High subclonal fraction of 17p deletion is associated with poor prognosis in multiple myeloma

17p缺失的高亚克隆比例与多发性骨髓瘤预后不良相关

Thakurta, Anjan; Ortiz, Maria; Blecua, Pedro; Towfic, Fadi; Corre, Jill; Serbina, Natalya V; Flynt, Erin; Yu, Zhinuan; Yang, Zhihong; Palumbo, Antonio; Dimopoulos, Meletios A; Gutierrez, Norma C; Goldschmidt, Hartmut; Sonneveld, Pieter; Avet-Loiseau, Herve

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

新型突变驱动因素的鉴定揭示了多发性骨髓瘤中的癌基因依赖性

Walker, Brian A; Mavrommatis, Konstantinos; Wardell, Christopher P; Ashby, T Cody; Bauer, Michael; Davies, Faith E; Rosenthal, Adam; Wang, Hongwei; Qu, Pingping; Hoering, Antje; Samur, Mehmet; Towfic, Fadi; Ortiz, Maria; Flynt, Erin; Yu, Zhinuan; Yang, Zhihong; Rozelle, Dan; Obenauer, John; Trotter, Matthew; Auclair, Daniel; Keats, Jonathan; Bolli, Niccolo; Fulciniti, Mariateresa; Szalat, Raphael; Moreau, Philippe; Durie, Brian; Stewart, A Keith; Goldschmidt, Hartmut; Raab, Marc S; Einsele, Hermann; Sonneveld, Pieter; San Miguel, Jesus; Lonial, Sagar; Jackson, Graham H; Anderson, Kenneth C; Avet-Loiseau, Herve; Munshi, Nikhil; Thakurta, Anjan; Morgan, Gareth J