日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Sequential Reconstruction of Calicheamicin γ(1) (I) Iodo-Thiobenzoate by Selective Carrier Protein Trapping Reveals a Flavin-Dependent Iodinase

通过选择性载体蛋白捕获对卡利奇霉素γ(1)(I)碘代硫代苯甲酸酯进行序列重构,揭示了一种黄素依赖性碘化酶

Pang, Fang; Townsend, Craig A

Structural Basis for 3-Amino-3-carboxypropyl Transfer in Nocardicin Biosynthesis

诺卡氏菌素生物合成中3-氨基-3-羧丙基转移的结构基础

Gao, Yaojie; Karasawa, Masayuki; Quan, Zhiyang; Mori, Takahiro; Kanaida, Masahiro; Townsend, Craig A; Terada, Tohru; Abe, Ikuro; Awakawa, Takayoshi

l-2,3-Diaminopropionate Binding Mode of the SulM Adenylation Domain Limits Engineering Monobactam Analogue Biosynthesis with Larger Substrates

1-2,3-二氨基丙酸酯与SulM腺苷酰化结构域的结合模式限制了利用较大底物进行单环β-内酰胺类似物生物合成的工程改造

Kahlert, Lukas; Patel, Ketan D; Lichstrahl, Michael S; Li, Rongfeng; He, Chengkun; Gulick, Andrew M; Townsend, Craig A

Erratum: The dabABC operon is a marker of C4-alkylated monobactam biosynthesis and responsible for (2S,3R)-diaminobutyrate production

更正:dabABC操纵子是C4烷基化单环β-内酰胺类抗生素生物合成的标志,负责(2S,3R)-二氨基丁酸的生成。

Li, Rongfeng; Lichstrahl, Michael S; Zandi, Trevor A; Kahlert, Lukas; Townsend, Craig A

The structure of the monobactam-producing thioesterase domain of SulM forms a unique complex with the upstream carrier protein domain

SulM的单环β-内酰胺酶结构域与上游载体蛋白结构域形成独特的复合物。

Patel, Ketan D; Oliver, Ryan A; Lichstrahl, Michael S; Li, Rongfeng; Townsend, Craig A; Gulick, Andrew M

Normal and Aberrant Methyltransferase Activities Give Insights into the Final Steps of Dynemicin A Biosynthesis

正常和异常的甲基转移酶活性为了解动力素A生物合成的最后步骤提供了重要线索。

Pal, Paramita; Wessely, Serena M L; Townsend, Craig A

Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam biosynthesis

功能化2,3-二氨基丙酸酯的合成及其在定向单环β-内酰胺类抗生素生物合成中的应用潜力

Lichstrahl, Michael S; Kahlert, Lukas; Li, Rongfeng; Zandi, Trevor A; Yang, Jerry; Townsend, Craig A

Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening

利用FRET耦合高通量诱导剂筛选靶向发现隐蔽的烯二炔天然产物

Han, Esther J; Lee, Seoung Rak; Townsend, Craig A; Seyedsayamdost, Mohammad R

Dynemicin A Derivatives as Potential Cancer Chemotherapeutics by Mutasynthesis

通过突变合成法制备动力素A衍生物作为潜在的抗癌化疗药物

Pal, Paramita; Alley, Jamie R; Cohen, Douglas R; Townsend, Craig A

Sea Urchin Polyketide Synthase SpPks1 Produces the Naphthalene Precursor to Echinoderm Pigments

海胆聚酮合酶 SpPks1 产生棘皮动物色素的萘前体

Li, Feng; Lin, Zhenjian; Torres, Joshua P; Hill, Eric A; Li, Dehai; Townsend, Craig A; Schmidt, Eric W