日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Veillonella and Streptococcus are associated with aging of the gut microbiota and affect the efficacy of immune checkpoint inhibitors

韦荣氏球菌和链球菌与肠道菌群老化有关，并影响免疫检查点抑制剂的疗效。

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2025.1528521
Hirasawa, Yuya; Isobe, Junya; Hosonuma, Masahiro; Tsurui, Toshiaki; Baba, Yuta; Funayama, Eiji; Tajima, Kohei; Murayama, Masakazu; Narikawa, Yoichiro; Toyoda, Hitoshi; Shida, Midori; Sasaki, Aya; Maruyama, Yuuki; Amari, Yasunobu; Mura, Emiko; Suzuki, Risako; Iriguchi, Nana; Ishiguro, Tomoyuki; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Kubota, Yutaro; Horiike, Atsushi; Sambe, Takehiko; Uchida, Naoki; Wada, Satoshi; Kobayashi, Shinichi; Kiuchi, Yuji; Kuramasu, Atsuo; Yoshimura, Kiyoshi; Tsunoda, Takuya
微生物学
肠道菌群
衰老
免疫/内分泌
发表日期：2025
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Inosine shapes PD-1 blockade responses and synergizes with dual PD-1/CTLA-4 immunotherapy to enhance antitumor immunity

肌苷可调控PD-1阻断反应，并与PD-1/CTLA-4双重免疫疗法产生协同作用，从而增强抗肿瘤免疫力。

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-025-04111-2
Narikawa, Yoichiro; Kuramasu, Atsuo; Hosonuma, Masahiro; Murayama, Masakazu; Funayama, Eiji; Sasaki, Akiko; Baba, Yuta; Toyoda, Hitoshi; Isobe, Junya; Tajima, Kohei; Nakashima, Rie; Sasaki, Aya; Maruyama, Yuki; Yamazaki, Yoshitaka; Shida, Midori; Tsurui, Toshiaki; Hirasawa, Yuya; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Ohkuma, Ryotaro; Kubota, Yutaro; Sambe, Takehiko; Tsuji, Mayumi; Wada, Satoshi; Horiike, Atsushi; Kobayashi, Shinichi; Tsunoda, Takuya; Kobayashi, Sei; Kobayashi, Hitome; Oguchi, Tatsunori; Shimane, Toshikazu; Kiuchi, Yuji; Yoshimura, Kiyoshi
肿瘤
肿瘤免疫
信号转导
PD-1
免疫/内分泌
发表日期：2025
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Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8(+) T cells as a predictor of clinical benefit

Ki-67在抗程序性细胞死亡蛋白-1抗体结合的CD8(+) T细胞中的表达可作为临床获益的预测指标

期刊:Discover Oncology
影响因子:2.9
doi:10.1007/s12672-025-02060-x
Tsurui, Toshiaki; Hosonuma, Masahiro; Sasaki, Aya; Maruyama, Yuuki; Amari, Yasunobu; Funayama, Eiji; Tajima, Kohei; Toyoda, Hitoshi; Isobe, Junya; Yamazaki, Yoshitaka; Baba, Yuta; Shida, Midori; Udaka, Yuko; Mura, Emiko; Suzuki, Risako; Iriguchi, Nana; Ishiguro, Tomoyuki; Hirasawa, Yuya; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Kubota, Yutaro; Horiike, Atsushi; Wada, Satoshi; Kuramasu, Atsuo; Tsuji, Mayumi; Kiuchi, Yuji; Tsunoda, Takuya; Yoshimura, Kiyoshi
T细胞
T细胞
CD8
免疫/内分泌
细胞生物学
Ki-67
发表日期：2025
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Butyricimonas is a key gut microbiome component for predicting postoperative recurrence of esophageal cancer

丁酸单胞菌是预测食管癌术后复发的关键肠道菌群组成部分

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-023-03608-y
Otsuka, Koji; Isobe, Junya; Asai, Yoshiyuki; Nakano, Tomohisa; Hattori, Kouya; Ariyoshi, Tomotake; Yamashita, Takeshi; Motegi, Kentaro; Saito, Akira; Kohmoto, Masahiro; Hosonuma, Masahiro; Kuramasu, Atsuo; Baba, Yuta; Murayama, Masakazu; Narikawa, Yoichiro; Toyoda, Hitoshi; Funayama, Eiji; Tajima, Kohei; Shida, Midori; Hirasawa, Yuya; Tsurui, Toshiaki; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Ohkuma, Ryotaro; Kubota, Yutaro; Sambe, Takehiko; Tsuji, Mayumi; Wada, Satoshi; Kiuchi, Yuji; Kobayashi, Shinichi; Horiike, Atsushi; Goto, Satoru; Murakami, Masahiko; Kim, Yun-Gi; Tsunoda, Takuya; Yoshimura, Kiyoshi
肿瘤
肿瘤免疫
微生物学
肠道菌群
食管癌
发表日期：2024
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Nivolumab receptor occupancy on effector regulatory T cells predicts clinical benefit

效应调节性T细胞上纳武利尤单抗受体的占有率可预测临床获益

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.16061
Hosonuma, Masahiro; Hirasawa, Yuya; Kuramasu, Atsuo; Murayama, Masakazu; Narikawa, Yoichiro; Toyoda, Hitoshi; Baba, Yuta; Isobe, Junya; Funayama, Eiji; Tajima, Kohei; Shida, Midori; Hamada, Kazuyuki; Tsurui, Toshiaki; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Ohkuma, Ryotaro; Kubota, Yutaro; Horiike, Atsushi; Sambe, Takehiko; Tsuji, Mayumi; Wada, Satoshi; Kiuchi, Yuji; Kobayashi, Shinichi; Tsunoda, Takuya; Yoshimura, Kiyoshi
T细胞
信号转导
T细胞
细胞生物学
免疫/内分泌
发表日期：2024
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Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody

异丁酸可增强抗PD-1抗体的抗肿瘤作用

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-024-59677-1
Murayama, Masakazu; Hosonuma, Masahiro; Kuramasu, Atsuo; Kobayashi, Sei; Sasaki, Akiko; Baba, Yuta; Narikawa, Yoichiro; Toyoda, Hitoshi; Isobe, Junya; Funayama, Eiji; Tajima, Kohei; Sasaki, Aya; Maruyama, Yuki; Yamazaki, Yoshitaka; Shida, Midori; Hamada, Kazuyuki; Hirasawa, Yuya; Tsurui, Toshiaki; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Ohkuma, Ryotaro; Kubota, Yutaro; Horiike, Atsushi; Sambe, Takehiko; Tsuji, Mayumi; Wada, Satoshi; Kobayashi, Shinichi; Shimane, Toshikazu; Tsunoda, Takuya; Kobayashi, Hitome; Kiuchi, Yuji; Yoshimura, Kiyoshi
肿瘤
肿瘤免疫
PD-1
发表日期：2024
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MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2D(Low) T cells.

MHC I 类多肽相关序列 B 的脱落通过激活 NKG2D(Low) T 细胞来调节胰腺肿瘤免疫

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-024-73712-1
Toyoda Hitoshi, Kuramasu Atsuo, Hosonuma Masahiro, Murayama Masakazu, Narikawa Yoichiro, Isobe Junya, Baba Yuta, Tajima Kohei, Funayama Eiji, Shida Midori, Maruyama Yuki, Sasaki Aya, Hirasawa Yuya, Tsurui Toshiaki, Ariizumi Hirotsugu, Ishiguro Tomoyuki, Suzuki Risako, Kobayashi Sei, Horiike Atsushi, Hida Noriko, Sambe Takehiko, Nobe Koji, Wada Satoshi, Kobayashi Hitome, Tsuji Mayumi, Kobayashi Shinichi, Tsunoda Takuya, Kudo Yoshifumi, Kiuchi Yuji, Yoshimura Kiyoshi
细胞生物学
肿瘤
肿瘤免疫
发表日期：2024
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Turicibacter and Acidaminococcus predict immune-related adverse events and efficacy of immune checkpoint inhibitor

特里西杆菌属和酸氨基球菌属可预测免疫相关不良事件和免疫检查点抑制剂的疗效

期刊:Frontiers in Immunology
影响因子:5.9
doi:10.3389/fimmu.2023.1164724
Hamada, Kazuyuki; Isobe, Junya; Hattori, Kouya; Hosonuma, Masahiro; Baba, Yuta; Murayama, Masakazu; Narikawa, Yoichiro; Toyoda, Hitoshi; Funayama, Eiji; Tajima, Kohei; Shida, Midori; Hirasawa, Yuya; Tsurui, Toshiaki; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Ohkuma, Ryotaro; Kubota, Yutaro; Sambe, Takehiko; Tsuji, Mayumi; Wada, Satoshi; Kiuchi, Yuji; Kobayashi, Shinichi; Kuramasu, Atsuo; Horiike, Atsushi; Kim, Yun-Gi; Tsunoda, Takuya; Yoshimura, Kiyoshi
免疫/内分泌
发表日期：2023
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