日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics

KRAS4a 和 KRAS4b 对 RAS-RAF 膜动力学表现出不同的脂质依赖性调控作用

Georgouli, Konstantia; Tempkin, Jeremy O B; Stanton, Liam G; Oppelstrup, Tomas; Shrestha, Rebika; Carpenter, Timothy S; Aydin, Fikret; Zhang, Xiaohua; Bhatia, Harsh; Yang, Yue; Van, Que N; Bonilla, Pedro Andrade; Gulten, Gulcin; Goswami, Debanjan; Di Natale, Francesco; Chavez, Joseph R; Moon, Joseph Y; Dharuman, Gautham; Hengartner, Nicolas W; Simanshu, Dhirendra K; Tran, Timothy H; Nguyen, Kien; Stanley, Christopher B; Van Essen, Brian; Bremer, Peer-Timo; Lightstone, Felice C; Stephen, Andrew G; Glosli, James N; Gnanakaran, Sandrasegaram; Turbyville, Thomas J; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H; Ingólfsson, Helgi I

Proline-based tripodal cages with guest-adaptive features for capturing hydrophilic and amphiphilic fluoride substances

具有客体自适应特征的脯氨酸基三脚笼状结构,用于捕获亲水性和两亲性氟化物

Huang, Bo; Li, Sihao; Pan, Cong; Li, Fangzhou; Wojtas, Lukasz; Qiao, Qiao; Tran, Timothy H; Calcul, Laurent; Liu, Wenqi; Ke, Chenfeng; Cai, Jianfeng

Discovery of peptidomimetic inhibitors of CREB/CBP by targeting hydrophobic grooves on the surface of the CBP KIX domain

通过靶向CBP KIX结构域表面的疏水沟槽,发现CREB/CBP的肽模拟抑制剂。

Huang, Bo; Gregory-Lott, Emily; Li, Bingbing X; Tran, Timothy H; Li, Sihao; Xue, Menglin; Wang, Shaohui; Asokan, Anabanadam; Shen, Ning; Sun, Xingming; Cao, Chuanhai; Xiao, Xiangshu; Daughdrill, Gary; Cai, Jianfeng

Unc-51 Like Kinase 3 (ULK3) is essential for autophagy and cell survival in multiple myeloma.

Unc-51 样激酶 3 (ULK3) 对多发性骨髓瘤的自噬和细胞存活至关重要

Tauro Marilena, Li Tao, Sudalagunta Praneeth R, Meads Mark, Canevarolo Rafael Renatino, Nerlakanti Niveditha, Alugubelli Raghunandan R, Lawrence Harshani R, Gunawan Steven, Ayaz Mohammad, Nareddy Pradeep, Yun Sang Young, Shay Gemma, Yang Kathy, Tran Timothy H, Bishop Ryan T, Nasr Mostafa M, Lawrence Nicholas N J, Schönbrunn Ernst, Cleveland John L, Silva Ariosto S, Shain Kenneth H, Lynch Conor C

Structural basis for FN3K-mediated protein deglycation.

FN3K介导的蛋白质去糖基化的结构基础

Lokhandwala Jameela, Matlack Jenet K, Smalley Tracess B, Miner Robert E 3rd, Tran Timothy H, Binning Jennifer M

Structural perspectives on recent breakthrough efforts toward direct drugging of RAS and acquired resistance

从结构角度探讨近期在直接靶向 RAS 和获得性耐药方面取得的突破性进展

Lokhandwala, Jameela; Smalley, Tracess B; Tran, Timothy H

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

Switch-II结构域的变构调节控制KRAS致癌性

Yang, Moon Hee; Tran, Timothy H; Hunt, Bethany; Agnor, Rebecca; Johnson, Christian W; Shui, Bing; Waybright, Timothy J; Nowak, Jonathan A; Stephen, Andrew G; Simanshu, Dhirendra K; Haigis, Kevin M

Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D)

降低动态复杂性使得KRAS(G13D)激发态的结构解析成为可能

Chao, Fa-An; Chan, Albert H; Dharmaiah, Srisathiyanarayanan; Schwieters, Charles D; Tran, Timothy H; Taylor, Troy; Ramakrishnan, Nitya; Esposito, Dominic; Nissley, Dwight V; McCormick, Frank; Simanshu, Dhirendra K; Cornilescu, Gabriel

Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

机器学习驱动的多尺度建模揭示了RAS信号蛋白的脂质依赖性动态变化

Ingólfsson, Helgi I; Neale, Chris; Carpenter, Timothy S; Shrestha, Rebika; López, Cesar A; Tran, Timothy H; Oppelstrup, Tomas; Bhatia, Harsh; Stanton, Liam G; Zhang, Xiaohua; Sundram, Shiv; Di Natale, Francesco; Agarwal, Animesh; Dharuman, Gautham; Kokkila Schumacher, Sara I L; Turbyville, Thomas; Gulten, Gulcin; Van, Que N; Goswami, Debanjan; Jean-Francois, Frantz; Agamasu, Constance; Chen, De; Hettige, Jeevapani J; Travers, Timothy; Sarkar, Sumantra; Surh, Michael P; Yang, Yue; Moody, Adam; Liu, Shusen; Van Essen, Brian C; Voter, Arthur F; Ramanathan, Arvind; Hengartner, Nicolas W; Simanshu, Dhirendra K; Stephen, Andrew G; Bremer, Peer-Timo; Gnanakaran, S; Glosli, James N; Lightstone, Felice C; McCormick, Frank; Nissley, Dwight V; Streitz, Frederick H

Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43

TDP-43假定聚集域中淀粉样原纤维形成的结构证据

Mompeán, Miguel; Hervás, Rubén; Xu, Yunyao; Tran, Timothy H; Guarnaccia, Corrado; Buratti, Emanuele; Baralle, Francisco; Tong, Liang; Carrión-Vázquez, Mariano; McDermott, Ann E; Laurents, Douglas V