日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dorsal root ganglion toxicity after AAV intra-CSF delivery of a RNAi expression construct into non-human primates and mice.

将 RNAi 表达构建体通过 AAV 脑脊液内递送至非人灵长类动物和小鼠后,引起背根神经节毒性

Hawley Zachary C E, Pardo Ingrid D, Cao Shaolong, Zavodszky Maria I, Casey Fergal, Ferber Kyle, Luo Yi, Hana Sam, Chen Shukkwan K, Doherty Jessica, Costa Raquel, Cullen Patrick, Liu Yuqing, Carlile Thomas M, Chowdhury Twinkle, Doyle Benjamin, Clarner Pete, Mangaudis Kevin, Guilmette Edward, Bourque Shawn, Koske David, Nadella Murali V P, Trapa Patrick, Hawes Michael L, Raitcheva Denitza, Lo Shih-Ching

A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase

一种模拟体内酶周转(在自杀性抑制剂药物存在下)的新方法:MAG脂肪酶的脑PET概念验证研究

Volpi, Tommaso; Holden, Daniel; Gallezot, Jean-Dominique; Nabulsi, Nabeel; Lim, Keunpoong; Labaree, David; Gao, Hong; Kapinos, Michael; Keliher, Edmund J; Fonseca, Kari R; Trapa, Patrick; Varrone, Andrea; Halldin, Christer; Maresca, Kevin P; Huang, Yiyun; Carson, Richard E

Inhibition of immune response reduces pathology in dorsal root ganglia and peripheral nerves in cynomolgus macaques following AAV gene therapy

抑制免疫反应可减轻食蟹猴在接受腺相关病毒(AAV)基因治疗后背根神经节和周围神经的病理变化。

Grubor, Branka; Henry, Kate L; Chan, Su Jing; Sheehan, Mark; Shah, Anumeha; Pellerin, Alex; Bai, Judy; Nadella, Prasad; Bommegowda, Santhosh; Cullen, Patrick; Tien, Eric; Chen, Vivian; van der Munnik, Nicholas P; White-Hunt, Stephanie; Plowey, Edward D; Hamann, Stefan; Guise, Amanda J; Xu, Shanqin; Kirkland, Melissa; Doherty, Jessica; Lyashenko, Eugenia; Bhat, Guruharsha; Glajch, Kelly; Lo, Shih-Ching; Gianni, Davide; Clarner, Pete; Gagnon, Jake; Chu, Jenhwa; Nambiar, Kalyani; Lulla, Mukesh; Zheng, Fengmei; Weldeab, Asmerom; Bartlett, Dan; Gutnick, Amos; Reynolds, Taylor; Zhu, Kan; Huh, Dann; Carlile, Thomas M; Fikes, James; Trapa, Patrick; Suh, Junghae; Morris, Dale; Burkly, Linda

Target occupancy study and whole-body dosimetry with a MAGL PET ligand [(11)C]PF-06809247 in non-human primates

在非人灵长类动物中利用 MAGL PET 配体 [(11)C]PF-06809247 进行靶区占有率研究和全身剂量测定

Arakawa, Ryosuke; Takano, Akihiro; Nag, Sangram; Jia, Zhisheng; Amini, Nahid; Maresca, Kevin P; Zhang, Lei; Keliher, Edmund J; Butler, Christopher R; Piro, Justin R; Samad, Tarek A; Smith, Deborah; Nason, Deane; O'Neil, Steve; Trapa, Patrick; Fonseca, Kari R; Litchfield, John; McCarthy, Timothy; Carson, Richard E; Halldin, Christer

Next-generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells

下一代布鲁顿酪氨酸激酶抑制剂 BIIB091 可选择性地有效抑制 B 细胞和 Fc 受体信号传导以及 B 细胞和髓细胞中的下游功能

Eris Bame, Hao Tang, Jeremy C Burns, Million Arefayene, Klaus Michelsen, Bin Ma, Isaac Marx, Robin Prince, Allie M Roach, Urjana Poreci, Douglas Donaldson, Patrick Cullen, Fergal Casey, Jing Zhu, Thomas M Carlile, Dipen Sangurdekar, Baohong Zhang, Patrick Trapa, Joseph Santoro, Param Muragan, Alex P

Optimization of dose and route of administration of the P-glycoprotein inhibitor, valspodar (PSC-833) and the P-glycoprotein and breast cancer resistance protein dual-inhibitor, elacridar (GF120918) as dual infusion in rats

在大鼠中优化 P-糖蛋白抑制剂 valspodar (PSC-833) 和 P-糖蛋白及乳腺癌耐药蛋白双重抑制剂 elacridar (GF120918) 的剂量和给药途径的双重输注

Rowbottom, Christopher; Pietrasiewicz, Alicia; Tuczewycz, Taras; Grater, Richard; Qiu, Daniel; Kapadnis, Sudarshan; Trapa, Patrick

Development of a one-step RT-ddPCR method to determine the expression and potency of AAV vectors

开发一步法 RT-ddPCR 方法来确定 AAV 载体的表达和效力

Pete Clarner, Shukkwan K Lau, Twinkle Chowdhury, Edward Guilmette, Patrick Trapa, Shih-Ching Lo, Shen Shen

Insights from mathematical modeling for convection-enhanced intraputamenal delivery of GDNF

利用数学模型研究对流增强型壳核内GDNF递送的启示

Belova, Elena; Shaffer, Christopher L; Trapa, Patrick E

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging

发现一种可调节大脑中 Tau 磷酸化的高选择性糖原合酶激酶 3 抑制剂 (PF-04802367):PET 神经影像学的转化

Steven H Liang, Jinshan Michael Chen, Marc D Normandin, Jeanne S Chang, George C Chang, Christine K Taylor, Patrick Trapa, Mark S Plummer, Kimberly S Para, Edward L Conn, Lori Lopresti-Morrow, Lorraine F Lanyon, James M Cook, Karl E G Richter, Charlie E Nolan, Joel B Schachter, Fouad Janat, Ye Che, 

Preclinical pharmacokinetic/pharmacodynamic modeling and simulation in the pharmaceutical industry: an IQ consortium survey examining the current landscape

制药行业临床前药代动力学/药效动力学建模与模拟:IQ联盟对当前形势的调查

Schuck, Edgar; Bohnert, Tonika; Chakravarty, Arijit; Damian-Iordache, Valeriu; Gibson, Christopher; Hsu, Cheng-Pang; Heimbach, Tycho; Krishnatry, Anu Shilpa; Liederer, Bianca M; Lin, Jing; Maurer, Tristan; Mettetal, Jerome T; Mudra, Daniel R; Nijsen, Marjoleen Jma; Raybon, Joseph; Schroeder, Patricia; Schuck, Virna; Suryawanshi, Satyendra; Su, Yaming; Trapa, Patrick; Tsai, Alice; Vakilynejad, Majid; Wang, Shining; Wong, Harvey