日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia.

联合靶向治疗可破坏 IDH2 和 TET2 突变型急性髓系白血病中的异常致癌信号传导并逆转表观遗传功能障碍

Shih Alan H, Meydan Cem, Shank Kaitlyn, Garrett-Bakelman Francine E, Ward Patrick S, Intlekofer Andrew M, Nazir Abbas, Stein Eytan M, Knapp Kristina, Glass Jacob, Travins Jeremy, Straley Kim, Gliser Camelia, Mason Christopher E, Yen Katharine, Thompson Craig B, Melnick Ari, Levine Ross L

A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model

突变型IDH2的小分子抑制剂可挽救D-2-羟基戊二酸尿症II型小鼠模型的心肌病

Wang, Fang; Travins, Jeremy; Lin, Zhizhong; Si, Yaguang; Chen, Yue; Powe, Josh; Murray, Stuart; Zhu, Dongwei; Artin, Erin; Gross, Stefan; Santiago, Stephanie; Steadman, Mya; Kernytsky, Andrew; Straley, Kimberly; Lu, Chenming; Pop, Ana; Struys, Eduard A; Jansen, Erwin E W; Salomons, Gajja S; David, Muriel D; Quivoron, Cyril; Penard-Lacronique, Virginie; Regan, Karen S; Liu, Wei; Dang, Lenny; Yang, Hua; Silverman, Lee; Agresta, Samuel; Dorsch, Marion; Biller, Scott; Yen, Katharine; Cang, Yong; Su, Shin-San Michael; Jin, Shengfang

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

发现首个能降低体内肿瘤2-HG水平的强效突变型IDH1抑制剂

Popovici-Muller, Janeta; Saunders, Jeffrey O; Salituro, Francesco G; Travins, Jeremy M; Yan, Shunqi; Zhao, Fang; Gross, Stefan; Dang, Lenny; Yen, Katharine E; Yang, Hua; Straley, Kimberly S; Jin, Shengfang; Kunii, Kaiko; Fantin, Valeria R; Zhang, Shunan; Pan, Qiongqun; Shi, Derek; Biller, Scott A; Su, Shinsan M