日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ablation of prostaglandin E(2) signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours

通过CAR T细胞中的双受体敲除消除前列腺素E(2)信号传导可增强实体瘤的治疗效果

Dörr, Janina; Gregor, Lisa; Lacher, Sebastian B; Oner, Arman; Sun, Yi; Piseddu, Ignazio; Fertig, Luisa; Spajic, Sebastijan; Lesch, Stefanie; Michaelides, Stefanos; Seifert, Matthias; Gottschlich, Adrian; Samson, Natasha; Majed, Lina; Briukhovetska, Daria; Simnica, Donjetë; Hartmann, Viktoria; Gabriel, Kathrin; Cohen, Sonia; Boland, Genevieve M; Andreu-Sanz, David; Carlini, Emanuele; Stock, Sophia; Holtermann, Anne; Müller, Philipp Jie; Strzalkowski, Thaddäus; Trefny, Marcel P; Endres, Stefan; Jenkins, Russell W; Böttcher, Jan P; Kobold, Sebastian

Dissection of single-cell landscapes for the development of chimeric antigen receptor T cells in Hodgkin lymphoma

解析单细胞图谱以研究霍奇金淋巴瘤中嵌合抗原受体T细胞的发育

Gottschlich, Adrian; Grünmeier, Ruth; Hoffmann, Gordon Victor; Nandi, Sayantan; Kavaka, Vladyslav; Müller, Philipp Jie; Jobst, Jakob; Oner, Arman; Kaiser, Rainer; Gärtig, Jan; Piseddu, Ignazio; Frenz-Wiessner, Stephanie; Fairley, Savannah D; Schulz, Heiko; Igl, Veronika; Janert, Thomas Alexander; Di Fina, Lea; Mulkers, Maité; Thomas, Moritz; Briukhovetska, Daria; Simnica, Donjetë; Carlini, Emanuele; Tsiverioti, Christina Angeliki; Trefny, Marcel P; Lorenzini, Theo; Märkl, Florian; Mesquita, Pedro; Brabenec, Ruben; Strzalkowski, Thaddäus; Stock, Sophia; Michaelides, Stefanos; Hellmuth, Johannes; Thelen, Martin; Reinke, Sarah; Klapper, Wolfram; Gelebart, Pascal Francois; Nicolai, Leo; Marr, Carsten; Beltrán, Eduardo; Megens, Remco T A; Klein, Christoph; Baran-Marszak, Fanny; Rosenwald, Andreas; von Bergwelt-Baildon, Michael; Bröckelmann, Paul J; Endres, Stefan; Kobold, Sebastian

Inhibition of Cbl-b restores effector functions of human intratumoral NK cells

抑制 Cbl-b 可恢复人类肿瘤内 NK 细胞的效应功能

Sofia Tundo, Marcel Trefny #, Andrijana Rodić #, Olivia Grueninger, Nicole Brodmann, Anastasiya Börsch, Clara Serger, Jonas Fürst, Melanie Buchi, Katarzyna Buczak, Alex T Müller, Lisa Sach-Peltason, Leyla Don, Petra Herzig, Didier Lardinois, Viola Heinzelmann-Schwarz, Kirsten D Mertz, Aljaž Hojski, 

Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy

删除SNX9可缓解CD8 T细胞耗竭,从而实现有效的细胞癌症免疫治疗。

Marcel P Trefny ,Nicole Kirchhammer ,Priska Auf der Maur ,Marina Natoli ,Dominic Schmid ,Markus Germann ,Laura Fernandez Rodriguez ,Petra Herzig ,Jonas Lötscher ,Maryam Akrami ,Jane C Stinchcombe ,Michal A Stanczak ,Andreas Zingg ,Melanie Buchi ,Julien Roux ,Romina Marone ,Leyla Don ,Didier Lardinois ,Mark Wiese ,Lukas T Jeker ,Mohamed Bentires-Alj ,Jérémie Rossy ,Daniela S Thommen ,Gillian M Griffiths ,Heinz Läubli ,Christoph Hess ,Alfred Zippelius

N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer

N-乙酰半胱氨酸可克服乳腺癌中由NF1缺失引起的对PI3Kα抑制剂的耐药性

Priska Auf der Maur,Marcel P Trefny,Zora Baumann,Milica Vulin,Ana Luisa Correia,Maren Diepenbruck,Nicolas Kramer,Katrin Volkmann,Bogdan-Tiberius Preca,Pedro Ramos,Cedric Leroy,Tobias Eichlisberger,Katarzyna Buczak,Federica Zilli,Ryoko Okamoto,Roland Rad,Michael Rugaard Jensen,Christine Fritsch,Alfred Zippelius,Michael B Stadler,Mohamed Bentires-Alj

Dual TLR9 and PD-L1 targeting unleashes dendritic cells to induce durable antitumor immunity

TLR9 和 PD-L1 双重靶向释放树突状细胞以诱导持久的抗肿瘤免疫力

Laura Fernandez-Rodriguez #, Chiara Cianciaruso #, Ruben Bill, Marcel P Trefny, Richard Klar, Nicole Kirchhammer, Mélanie Buchi, Julia Festag, Sven Michel, Rainer H Kohler, Elham Jones, Andre Maaske, Johannes Vom Berg, Sebastian Kobold, Abhishek S Kashyap, Frank Jaschinski, Karen O Dixon, Mikael J P

13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion

13C 示踪剂分析揭示人类 CD8+ T 细胞分化和衰竭中的代谢检查点情况

Alexander Kirchmair, Niloofar Nemati, Giorgia Lamberti, Marcel Trefny, Anne Krogsdam, Anita Siller, Paul Hörtnagl, Petra Schumacher, Sieghart Sopper, Adolf Sandbichler, Alfred Zippelius, Bart Ghesquière, Zlatko Trajanoski

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade

靶向癌症糖基化可使肿瘤相关巨噬细胞重新极化,从而实现有效的免疫检查点阻断

Michal A Stanczak, Natalia Rodrigues Mantuano, Nicole Kirchhammer, David E Sanin, Francis Jacob, Ricardo Coelho, Arun V Everest-Dass, Jinyu Wang, Marcel P Trefny, Gianni Monaco, Anne Bärenwaldt, Melissa A Gray, Adam Petrone, Abhishek S Kashyap, Katharina Glatz, Benjamin Kasenda, Karl Normington, Jam

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

CD36 介导的代谢适应支持调节性 T 细胞在肿瘤中的存活和功能

Haiping Wang, Fabien Franco, Yao-Chen Tsui, Xin Xie, Marcel P Trefny, Roberta Zappasodi, Syed Raza Mohmood, Juan Fernández-García, Chin-Hsien Tsai, Isabell Schulze, Florence Picard, Etienne Meylan, Roy Silverstein, Ira Goldberg, Sarah-Maria Fendt, Jedd D Wolchok, Taha Merghoub, Camilla Jandus, Alfre

PD-1(+) natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade

PD-1/PD-L1阻断可激活人非小细胞肺癌中的PD-1(+)自然杀伤细胞

Trefny, Marcel P; Kaiser, Monika; Stanczak, Michal A; Herzig, Petra; Savic, Spasenija; Wiese, Mark; Lardinois, Didier; Läubli, Heinz; Uhlenbrock, Franziska; Zippelius, Alfred