文献库，生知库 | 链接生命科学的每一步

Ibrahim M Sabbarini, Dvir Reif, Kibum Park, Alexander J McQuown, Anjali R Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I Shakhnovich, Andrew W Murray, Vladimir Denic

发表日期：2025

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Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model

在基于 CRISPR/Cas9 的 LRP2 敲除人肾细胞模型中，放射性标记的 15 肽内化是由巨蛋白（LRP2 受体）介导的。

期刊:EJNMMI Radiopharmacy and Chemistry

影响因子:3.3

doi:10.1186/s41181-024-00262-2

Durinova, Anna; Smutna, Lucie; Barta, Pavel; Kamaraj, Rajamanikkam; Smutny, Tomas; Schmierer, Bernhard; Pavek, Petr; Trejtnar, Frantisek

Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney

验证新鲜分离的大鼠肾细胞作为放射性标记受体特异性肽在肾脏中摄取的临床前评估工具的有效性

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph16050696

Barta, Pavel; Nachtigal, Petr; Maixnerova, Jana; Zemankova, Lenka; Trejtnar, Frantisek

Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α

自磷酸化的 C 末端与 CK1δ 激酶结构域之间的模糊相互作用抑制了 TAp63α 的活化

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-023-43515-x

Mahil Lambert #, Jakob Gebel #, Charlotte Trejtnar, Nicole Wesch, Süleyman Bozkurt, Martin Adrian-Allgood, Frank Löhr, Christian Münch, Volker Dötsch

表观遗传

发表日期：2023

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New total synthesis and structure confirmation of putative (+)-hyacinthacine C3 and (+)-5- epi-hyacinthacine C3

假定的 (+)-hyacinthacine C3 和 (+)-5-epi-hyacinthacine C3 的新全合成和结构确认

期刊:RSC Advances

影响因子:3.9

doi:10.1039/d1ra06225e

Lívia Dikošová, Barbora Otočková, Tomáš Malatinský, Jana Doháňošová, Mária Kopáčová, Anna Ďurinová, Lucie Smutná, František Trejtnar, Róbert Fischer

信号转导

发表日期：2021

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Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid

高活性抗分枝杆菌2-(2-异烟酰肼亚甲基)丙酸互酯的设计与合成

期刊:Pharmaceuticals

影响因子:

doi:10.3390/ph14121302

Václav Pflégr, Jana Maixnerová, Jiřina Stolaříková, Adrián Pál, Jana Korduláková, František Trejtnar, Jarmila Vinšová, Martin Krátký

微生物学

发表日期：2021

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Novel Aminoguanidine Hydrazone Analogues: From Potential Antimicrobial Agents to Potent Cholinesterase Inhibitors

新型氨基胍腙类似物：从潜在的抗菌剂到强效胆碱酯酶抑制剂

期刊:Pharmaceuticals

影响因子:

doi:10.3390/ph14121229

Martin Krátký, Šárka Štěpánková, Klára Konečná, Katarína Svrčková, Jana Maixnerová, Markéta Švarcová, Ondřej Janďourek, František Trejtnar, Jarmila Vinšová

微生物学

发表日期：2021

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3-Substituted N-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation

3-取代N-苄基吡嗪-2-甲酰胺衍生物的合成、抗分枝杆菌及抗菌评价

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules22030495

Lucia Semelková, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Lucie Navrátilová, František Trejtnar, Vladimír Kubíček, Jiří Kuneš, Martin Doležal, Jan Zitko0

免疫

发表日期：2017

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Sulfadiazine Salicylaldehyde-Based Schiff Bases: Synthesis, Antimicrobial Activity and Cytotoxicity

磺胺嘧啶水杨醛基席夫碱：合成、抗菌活性和细胞毒性

期刊:Molecules

影响因子:4.2

doi:10.3390/molecules22091573

Martin Krátký, Magdaléna Dzurková, Jiří Janoušek, Klára Konečná, František Trejtnar, Jiřina Stolaříková, Jarmila Vinšová

Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug-Drug Interactions

恩替卡韦与流入转运蛋白 hOAT1、hCNT2、hCNT3 相互作用，但不与 hOCT2 相互作用：肾脏转运蛋白介导的细胞毒性和药物相互作用的可能性

期刊:Frontiers in Pharmacology

影响因子:4.4

doi:10.3389/fphar.2015.00304

Jana Mandíková, Marie Volková, Petr Pávek, Lucie Navrátilová, Lucie Hyršová, Zlatko Janeba, Jan Pavlík, Pavel Bárta, František Trejtnar

A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A

核糖体结合分子伴侣介导GTP驱动的新生eEF1A矢量折叠

Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model

在基于 CRISPR/Cas9 的 LRP2 敲除人肾细胞模型中，放射性标记的 15 肽内化是由巨蛋白（LRP2 受体）介导的。

Validation of Freshly Isolated Rat Renal Cells as a Tool for Preclinical Assessment of Radiolabeled Receptor-Specific Peptide Uptake in the Kidney

验证新鲜分离的大鼠肾细胞作为放射性标记受体特异性肽在肾脏中摄取的临床前评估工具的有效性

Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α

自磷酸化的 C 末端与 CK1δ 激酶结构域之间的模糊相互作用抑制了 TAp63α 的活化

New total synthesis and structure confirmation of putative (+)-hyacinthacine C3 and (+)-5- epi-hyacinthacine C3

假定的 (+)-hyacinthacine C3 和 (+)-5-epi-hyacinthacine C3 的新全合成和结构确认

Design and Synthesis of Highly Active Antimycobacterial Mutual Esters of 2-(2-Isonicotinoylhydrazineylidene)propanoic Acid

高活性抗分枝杆菌2-(2-异烟酰肼亚甲基)丙酸互酯的设计与合成

Novel Aminoguanidine Hydrazone Analogues: From Potential Antimicrobial Agents to Potent Cholinesterase Inhibitors

新型氨基胍腙类似物：从潜在的抗菌剂到强效胆碱酯酶抑制剂

3-Substituted N-Benzylpyrazine-2-carboxamide Derivatives: Synthesis, Antimycobacterial and Antibacterial Evaluation

3-取代N-苄基吡嗪-2-甲酰胺衍生物的合成、抗分枝杆菌及抗菌评价

Sulfadiazine Salicylaldehyde-Based Schiff Bases: Synthesis, Antimicrobial Activity and Cytotoxicity

磺胺嘧啶水杨醛基席夫碱：合成、抗菌活性和细胞毒性

Entecavir Interacts with Influx Transporters hOAT1, hCNT2, hCNT3, but Not with hOCT2: The Potential for Renal Transporter-Mediated Cytotoxicity and Drug-Drug Interactions

恩替卡韦与流入转运蛋白 hOAT1、hCNT2、hCNT3 相互作用，但不与 hOCT2 相互作用：肾脏转运蛋白介导的细胞毒性和药物相互作用的可能性