日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists.

结构导向的二聚体构象交联和连接子工程增强了双特异性 VHH 细胞因子激动剂的热稳定性并微调了其活性

Trenker Raphael, Rokkam Deepti, Morin Andrew, Balasubrahmanyam Priyanka, Paredes Verenice, Cheng Ivan, de Waal Malefyt Rene, Oft Martin, Lupardus Patrick, Vivona Sandro

Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

活性HER4和HER2/HER4复合物的结构动力学受到不同生长因子和糖基化的精细调控。

Trenker, Raphael; Diwanji, Devan; Bingham, Tanner; Verba, Kliment A; Jura, Natalia

Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface

HER2-HER3-NRG1β复合物的结构揭示了一个动态的二聚体界面。

Diwanji, Devan; Trenker, Raphael; Thaker, Tarjani M; Wang, Feng; Agard, David A; Verba, Kliment A; Jura, Natalia

Mutant HER2 needs mutant HER3 to be an effective oncogene

突变型HER2需要突变型HER3才能发挥有效的致癌作用。

Trenker, Raphael; Diwanji, Devan; Jura, Natalia

Human and viral membrane-associated E3 ubiquitin ligases MARCH1 and MIR2 recognize different features of CD86 to downregulate surface expression.

人类和病毒膜相关 E3 泛素连接酶 MARCH1 和 MIR2 识别 CD86 的不同特征,从而下调其表面表达

Trenker Raphael, Wu Xinyu, Nguyen Julie V, Wilcox Stephen, Rubin Alan F, Call Matthew E, Call Melissa J

An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike

一种超强效合成纳米抗体通过稳定非活性刺突蛋白来中和SARS-CoV-2病毒。

Schoof, Michael; Faust, Bryan; Saunders, Reuben A; Sangwan, Smriti; Rezelj, Veronica; Hoppe, Nick; Boone, Morgane; Billesbølle, Christian B; Puchades, Cristina; Azumaya, Caleigh M; Kratochvil, Huong T; Zimanyi, Marcell; Deshpande, Ishan; Liang, Jiahao; Dickinson, Sasha; Nguyen, Henry C; Chio, Cynthia M; Merz, Gregory E; Thompson, Michael C; Diwanji, Devan; Schaefer, Kaitlin; Anand, Aditya A; Dobzinski, Niv; Zha, Beth Shoshana; Simoneau, Camille R; Leon, Kristoffer; White, Kris M; Chio, Un Seng; Gupta, Meghna; Jin, Mingliang; Li, Fei; Liu, Yanxin; Zhang, Kaihua; Bulkley, David; Sun, Ming; Smith, Amber M; Rizo, Alexandrea N; Moss, Frank; Brilot, Axel F; Pourmal, Sergei; Trenker, Raphael; Pospiech, Thomas; Gupta, Sayan; Barsi-Rhyne, Benjamin; Belyy, Vladislav; Barile-Hill, Andrew W; Nock, Silke; Liu, Yuwei; Krogan, Nevan J; Ralston, Corie Y; Swaney, Danielle L; García-Sastre, Adolfo; Ott, Melanie; Vignuzzi, Marco; Walter, Peter; Manglik, Aashish

Receptor tyrosine kinase activation: From the ligand perspective

受体酪氨酸激酶激活:从配体角度看

Trenker, Raphael; Jura, Natalia

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

SARS-CoV-2-人类蛋白质-蛋白质相互作用图谱揭示药物靶点和潜在药物再利用

Gordon, David E; Jang, Gwendolyn M; Bouhaddou, Mehdi; Xu, Jiewei; Obernier, Kirsten; O'Meara, Matthew J; Guo, Jeffrey Z; Swaney, Danielle L; Tummino, Tia A; Huettenhain, Ruth; Kaake, Robyn M; Richards, Alicia L; Tutuncuoglu, Beril; Foussard, Helene; Batra, Jyoti; Haas, Kelsey; Modak, Maya; Kim, Minkyu; Haas, Paige; Polacco, Benjamin J; Braberg, Hannes; Fabius, Jacqueline M; Eckhardt, Manon; Soucheray, Margaret; Bennett, Melanie J; Cakir, Merve; McGregor, Michael J; Li, Qiongyu; Naing, Zun Zar Chi; Zhou, Yuan; Peng, Shiming; Kirby, Ilsa T; Melnyk, James E; Chorba, John S; Lou, Kevin; Dai, Shizhong A; Shen, Wenqi; Shi, Ying; Zhang, Ziyang; Barrio-Hernandez, Inigo; Memon, Danish; Hernandez-Armenta, Claudia; Mathy, Christopher J P; Perica, Tina; Pilla, Kala B; Ganesan, Sai J; Saltzberg, Daniel J; Ramachandran, Rakesh; Liu, Xi; Rosenthal, Sara B; Calviello, Lorenzo; Venkataramanan, Srivats; Liboy-Lugo, Jose; Lin, Yizhu; Wankowicz, Stephanie A; Bohn, Markus; Sharp, Phillip P; Trenker, Raphael; Young, Janet M; Cavero, Devin A; Hiatt, Joseph; Roth, Theodore L; Rathore, Ujjwal; Subramanian, Advait; Noack, Julia; Hubert, Mathieu; Roesch, Ferdinand; Vallet, Thomas; Meyer, Björn; White, Kris M; Miorin, Lisa; Rosenberg, Oren S; Verba, Kliment A; Agard, David; Ott, Melanie; Emerman, Michael; Ruggero, Davide; García-Sastre, Adolfo; Jura, Natalia; von Zastrow, Mark; Taunton, Jack; Ashworth, Alan; Schwartz, Olivier; Vignuzzi, Marco; d'Enfert, Christophe; Mukherjee, Shaeri; Jacobson, Matt; Malik, Harmit S; Fujimori, Danica G; Ideker, Trey; Craik, Charles S; Floor, Stephen; Fraser, James S; Gross, John; Sali, Andrej; Kortemme, Tanja; Beltrao, Pedro; Shokat, Kevan; Shoichet, Brian K; Krogan, Nevan J