日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo

高效、选择性强且口服生物利用度高的VPS34抑制剂为体内自噬调控提供了化学工具

Honda, Ayako; Harrington, Edmund; Cornella-Taracido, Ivan; Furet, Pascal; Knapp, Mark S; Glick, Meir; Triantafellow, Ellen; Dowdle, William E; Wiedershain, Dmitri; Maniara, Wieslawa; Moore, Christine; Finan, Peter M; Hamann, Lawrence G; Firestone, Brant; Murphy, Leon O; Keaney, Erin P

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

选择性 VPS34 抑制剂阻断自噬并揭示 NCOA4 在体内铁蛋白降解和铁稳态中的作用

William E Dowdle, Beat Nyfeler, Jane Nagel, Robert A Elling, Shanming Liu, Ellen Triantafellow, Suchithra Menon, Zuncai Wang, Ayako Honda, Gwynn Pardee, John Cantwell, Catherine Luu, Ivan Cornella-Taracido, Edmund Harrington, Peter Fekkes, Hong Lei, Qing Fang, Mary Ellen Digan, Debra Burdick, Andrew

Defective autophagy and mTORC1 signaling in myotubularin null mice

肌管蛋白缺失小鼠的自噬和 mTORC1 信号传导存在缺陷

Kristina M Fetalvero, Yenyen Yu, Margaret Goetschkes, Guiqing Liang, Reginald A Valdez, Ty Gould, Ellen Triantafellow, Sebastian Bergling, Joseph Loureiro, John Eash, Victor Lin, Jeffrey A Porter, Peter M Finan, Kenneth Walsh, Yi Yang, Xiaohong Mao, Leon O Murphy

Relieving autophagy and 4EBP1 from rapamycin resistance

缓解自噬和 4EBP1 的雷帕霉素耐药性

Beat Nyfeler, Philip Bergman, Ellen Triantafellow, Christopher J Wilson, Yanyi Zhu, Branko Radetich, Peter M Finan, Daniel J Klionsky, Leon O Murphy

Bidirectional transport of amino acids regulates mTOR and autophagy

氨基酸的双向运输调节 mTOR 和自噬

Paul Nicklin, Philip Bergman, Bailin Zhang, Ellen Triantafellow, Henry Wang, Beat Nyfeler, Haidi Yang, Marc Hild, Charles Kung, Christopher Wilson, Vic E Myer, Jeffrey P MacKeigan, Jeffrey A Porter, Y Karen Wang, Lewis C Cantley, Peter M Finan, Leon O Murphy