日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

First-in-Human Phase I Study of KPT-9274, a First-in-Class Dual Inhibitor of PAK4 and NAMPT, in Patients with Advanced Solid Malignancies

KPT-9274(一种首创的PAK4和NAMPT双重抑制剂)在晚期实体恶性肿瘤患者中的首次人体I期研究

Razak, Albiruni; Mahipal, Amit; Diamond, Jennifer R; Ribas, Antoni; Berlin, Jordan David; Azmi, Asfar S; Mark, Tomer; Walker, Christopher J; Chai, Yi; Kashyap, Trinayan; Gudi, Girish; Naing, Aung

Focusing on Selinexor for Holding and Bridging Prior to CAR-T in Relapsed/Refractory Multiple Myeloma

重点关注塞利尼索在复发/难治性多发性骨髓瘤CAR-T治疗前的维持和桥接治疗中的应用

Khouri, Jack; Sborov, Douglas; Rossi, Adriana; Martin, Thomas; Kashyap, Trinayan; Mark, Tomer; Baljevic, Muhamed

Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis

循环中铁和硒水平较低,且 IL-6/IL-10 比率较高,可为结核病患者提供营养免疫

Sandeep R Kaushik, Sukanya Sahu, Hritusree Guha, Sourav Saha, Ranjit Das, Rukuwe-U Kupa, Wetetsho Kapfo, Trinayan Deka, Rumi Basumatary, Asunu Thong, Arunabha Dasgupta, Bidhan Goswami, Amit Kumar Pandey, Lahari Saikia, Vinotsole Khamo, Anjan Das, Ranjan Kumar Nanda

Small Molecule Inhibitors of Nuclear Export and the Amelioration of Lupus by Modulation of Plasma Cell Generation and Survival

小分子核输出抑制剂通过调节浆细胞生成和存活改善狼疮

Rangel-Moreno, Javier; Garcia-Hernandez, Maria de la Luz; Owen, Teresa; Barnard, Jennifer; Becerril-Villanueva, Enrique; Kashyap, Trinayan; Argueta, Christian; Gamboa-Dominguez, Armando; Tamir, Sharon; Landesman, Yosef; Goldman, Bruce I; Ritchlin, Christopher T; Anolik, Jennifer H

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms

Selinexor 单独使用或与 abemaciclib 联合使用可通过多种机制抑制患者体内脊索瘤的生长

Christopher J Walker, Hua Chang, Leah Henegar, Trinayan Kashyap, Sharon Shacham, Josh Sommer, Michael J Wick, Joan Levy, Yosef Landesman

HAPLN1 confers multiple myeloma cell resistance to several classes of therapeutic drugs

HAPLN1 使多发性骨髓瘤细胞对几类治疗药物产生耐药性

Mailee Huynh, Hae Yeun Chang, Dominique N Lisiero, Irene M Ong, Trinayan Kashyap, Natalie S Callander, Shigeki Miyamoto

A Case Report of a 58-Year-Old Woman with a Diagnosis of High-Risk Myeloma Refractory to Multiple Line of Therapy and Treated with Selinexor, Bortezomib, and Dexamethasone Prior to Allogeneic Stem Cell Transplantation

一例58岁女性高危多发性骨髓瘤病例报告,该患者对多种治疗方案无效,在接受异基因造血干细胞移植前曾接受塞利尼索、硼替佐米和地塞米松治疗。

Cass, Michael; McDonald, Andrew B; Ben-Shahar, Osnat; Landesman, Yosef; Kashyap, Trinayan

Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo

Selinexor 是一种新型选择性核输出抑制剂,可减少 SARS-CoV-2 感染并保护体内呼吸系统

Trinayan Kashyap, Jackelyn Murray, Christopher J Walker, Hua Chang, Sharon Tamir, Bing Hou, Sharon Shacham, Michael G Kauffman, Ralph A Tripp, Yosef Landesman

Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells

核输出抑制剂 KPT-8602 与 PARP 抑制剂协同作用,促进去势抵抗性癌细胞凋亡

Md Hafiz Uddin, Yiwei Li, Husain Yar Khan, Irfana Muqbil, Amro Aboukameel, Rachel E Sexton, Shriya Reddy, Yosef Landesman, Trinayan Kashyap, Asfar S Azmi, Elisabeth I Heath

Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma

Exportin 1 抑制剂诱导神经生长因子受体表达,从而抑制儿童高级别胶质瘤临床前模型中的 NF-κB 通路

DeSisto, John A; Flannery, Patrick; Lemma, Rakeb; Pathak, Amrita; Mestnik, Shelby; Philips, Natalie; Bales, Natalie J; Kashyap, Trinayan; Moroze, Erin; Venkataraman, Sujatha; Kung, Andrew L; Carter, Bruce D; Landesman, Yosef; Vibhakar, Rajeev; Green, Adam L