日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Efficient transgene-free multiplexed germline editing via viral delivery of an engineered TnpB

通过病毒载体递送工程化TnpB,实现高效的无转基因多重种系编辑

Weiss, Trevor; Kamalu, Maris; Shi, Honglue; Wirnowski, Gabriel; Ingelsson, Alice; Amerasekera, Jasmine; Vohra, Kamakshi; Trinidad, Marena I; Li, Zheng; Freitas, Emily; Steinmetz, Noah; Ambrose, Charlie; Chen, Kerry; Doudna, Jennifer A; Jacobsen, Steven E

Stepwise DNA unwinding gates TnpB genome-editing activity

逐步DNA解旋调控TnpB基因组编辑活性

Zhou, Zehan; Saffarian-Deemyad, Iren; Shi, Honglue; Weiss, Trevor; Ur-Rehman, Muhammad Moez; Vohra, Kamakshi; Skopintsev, Petr; Yoon, Peter H; Trinidad, Marena I; Langeberg, Conner J; Kamalu, Maris; Amerasekera, Jasmine; Doherty, Erin E; Aris, Kevin D P; Al-Sayyad, Noor; Thornton, Brittney W; Weissman, Rachel F; Wasko, Kevin M; Esain-Garcia, Isabel; DeTurk, Evan C; Savage, David F; Jacobsen, Steven E; Bryant, Zev; Doudna, Jennifer A

Spligation enables programmable chimeric RNA generation in living cells

连接技术可在活细胞中实现可编程嵌合RNA的生成。

Colognori, David A; Wasko, Kevin M; Trinidad, Marena I; Zhou, Zehan; Doudna, Jennifer A

Gene Portals: A Framework for Integrating Clinical, Functional, and Structural Evidence into Rare Disease Variant Classification

基因门户:将临床、功能和结构证据整合到罕见病变异分类中的框架

Brünger, Tobias; Krey, Ilona; Kim, Suyeon; Klöckner, Chiara; Myers, Scott J; Johannesen, Katrine M; Stefanski, Arthur; Taylor, Gary; Perez-Palma, Eduardo; Macnee, Marie; Schorge, Stephanie; Dahl, Rebekka S; Yuan, Hongjie; Perszyk, Riley E; Kim, Sukhan; Bajaj, Sunanjay; Helbig, Ingo; Pan, Jen Q; Farrant, Mark; Wollmuth, Lonnie; Wyllie, David J A; Kurganov, Erkin; Baez, David; Zuberi, Sameer; Boßelmann, Christian M; Lerche, Holger; Mantegazza, Massimo; Cestèle, Sandrine; May, Patrick; Ivaniuk, Alina; Meskis, Mary Anne; Hood, Veronica; Schust, Leah; Goodspeed, Kimberly; Kang, Jing-Qiong; Freed, Amber; Gati, Cornelius; Montanucci, Ludovica; Wuster, Arthur; Trinidad, Marena; Froelich, Steven; Deng, Alexander T; Serrano, Ángel Aledo; Borovikov, Artem; Sharkov, Artem; Bouman, Arjan; Hajianpour, M J; Pal, Deb K; Danvoye, Leslie; Lederer, Damien; Balci, Tugce R; Hagebeuk, Eveline E O; Heidlebaugh, Alexis; Oetjens, Kathryn; Hoffman, Trevor L; Striano, Pasquale; Williams, Sarah Drewes; van Engelen, Kalene; Howell, Katherine B; Khoury, Jean; Benke, Tim A; Strehlow, Vincent; Platzer, Konrad; Ramsey, Amy; Manaster, Lisa; Malepati, Sunitha; Fox, Pangkong; Noebels, Jeffrey; Chung, Wendy; Poduri, Annapurna; Stripe, Laina Lusk; Ruggiero, Sarah M; Cohen, Stacey; Smith, Lacey; Boesch, Sylvia; Wilmarth, Olivia; Prentice, Anna Jenne; Cha, Esther; Budnik, Nikita; Hommersom, Marina P; Kramer, Audra; Vanoye, Carlos G; Zhang, Guo-Qiang; Nothnagel, Michael; Palotie, Aarno; Daly, Mark J; George, Alfred L Jr; Zarate, Yuri A; Brunklaus, Andreas; Traynelis, Stephen F; Møller, Rikke S; Lemke, Johannes R; Lal, Dennis

CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d.

CRISPRi-ART 利用 RNA 结合 dCas13d 对多种噬菌体进行功能基因组学研究

Adler Benjamin A, Al-Shimary Muntathar J, Patel Jaymin R, Armbruster Emily G, Colognori David, Charles Emeric J, Miller Kate V, Lahiri Arushi, Cui Michael L, Oromí-Bosch Agnès, Voelker Angela, Trinidad Marena, Lee Jina, Beurnier Sebastien, Boger Ron, Nomburg Jason, Barrangou Rodolphe, Mutalik Vivek K, Schoeniger Joseph S, Pogliano Joseph A, Savage David F, Doudna Jennifer A, Cress Brady F

Directed evolution expands CRISPR-Cas12a genome-editing capacity

定向进化扩展了 CRISPR-Cas12a 基因组编辑能力

Ma, Enbo; Chen, Kai; Shi, Honglue; Wasko, Kevin M; Esain-Garcia, Isabel; Trinidad, Marena I; Zhou, Kaihong; Ye, Jinjuan; Doudna, Jennifer A

Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra.

阿尔茨海默病中选择性神经元脆弱性的潜在通路:脆弱的蓝斑核与坚韧的黑质形成对比

Ehrenberg Alexander J, Sant Cathrine, Pereira Felipe L, Li Song Hua, Buxton Jessica, Langlois Sonali, Trinidad Marena, Oh Ian, Leite Renata Elaine Paraizo, Rodriguez Roberta Diehl, Paes Vitor Ribeiro, Pasqualucci Carlos Agusto, Seeley William W, Spina Salvatore, Suemoto Claudia K, Temple Sally, Kaufer Daniela, Grinberg Lea T

eIF3 engages with 3'-UTR termini of highly translated mRNAs

eIF3 与高度翻译的 mRNA 的 3'-UTR 末端结合

Mestre-Fos, Santi; Ferguson, Lucas; Trinidad, Marena I; Ingolia, Nicholas T; Cate, Jamie H D

Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A

对芳基硫酸酯酶A中意义不明的变体的酶活性预测进行评估

Jain, Shantanu; Trinidad, Marena; Nguyen, Thanh Binh; Jones, Kaiya; Neto, Santiago Diaz; Ge, Fang; Glagovsky, Ailin; Jones, Cameron; Moran, Giankaleb; Wang, Boqi; Rahimi, Kobra; Çalıcı, Sümeyra Zeynep; Cedillo, Luis R; Berardelli, Silvia; Özden, Buse; Chen, Ken; Katsonis, Panagiotis; Williams, Amanda; Lichtarge, Olivier; Rana, Sadhna; Pradhan, Swatantra; Srinivasan, Rajgopal; Sajeed, Rakshanda; Joshi, Dinesh; Faraggi, Eshel; Jernigan, Robert; Kloczkowski, Andrzej; Xu, Jierui; Song, Zigang; Özkan, Selen; Padilla, Natàlia; de la Cruz, Xavier; Acuna-Hidalgo, Rocio; Grafmüller, Andrea; Barrón, Laura T Jiménez; Manfredi, Matteo; Savojardo, Castrense; Babbi, Giulia; Martelli, Pier Luigi; Casadio, Rita; Sun, Yuanfei; Zhu, Shaowen; Shen, Yang; Pucci, Fabrizio; Rooman, Marianne; Cia, Gabriel; Raimondi, Daniele; Hermans, Pauline; Kwee, Sofia; Chen, Ella; Astore, Courtney; Kamandula, Akash; Pejaver, Vikas; Ramola, Rashika; Velyunskiy, Michelle; Zeiberg, Daniel; Mishra, Reet; Sterling, Teague; Goldstein, Jennifer L; Lugo-Martinez, Jose; Kazi, Sufyan; Li, Sindy; Long, Kinsey; Brenner, Steven E; Bakolitsa, Constantina; Radivojac, Predrag; Suhr, Dean; Suhr, Teryn; Clark, Wyatt T

Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases

基于结构的祖先 CRISPR-Cas13 核糖核酸酶的发现

Yoon, Peter H; Zhang, Zeyuan; Loi, Kenneth J; Adler, Benjamin A; Lahiri, Arushi; Vohra, Kamakshi; Shi, Honglue; Rabelo, Daniel Bellieny; Trinidad, Marena; Boger, Ron S; Al-Shimary, Muntathar J; Doudna, Jennifer A