日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触。

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Cedeño Kwong Claudia, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids.

MEF2C自闭症患者hiPSC神经元和脑类器官中miRNA表达和兴奋失调

Trudler Dorit, Ghatak Swagata, Bula Michael, Parker James, Talantova Maria, Luevanos Melissa, Labra Sergio, Grabauskas Titas, Noveral Sarah Moore, Teranaka Mayu, Schahrer Emily, Dolatabadi Nima, Bakker Clare, Lopez Kevin, Sultan Abdullah, Patel Parth, Chan Agnes, Choi Yongwook, Kawaguchi Riki, Stankiewicz Pawel, Garcia-Bassets Ivan, Kozbial Piotr, Rosenfeld Michael G, Nakanishi Nobuki, Geschwind Daniel H, Chan Shing Fai, Lin Wei, Schork Nicholas J, Ambasudhan Rajesh, Lipton Stuart A

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Kwong Claudia Cedeño, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection

ACE2蛋白的靶向S-亚硝基化可抑制SARS-CoV-2感染

Chang-Ki Oh ,Tomohiro Nakamura ,Nathan Beutler ,Xu Zhang ,Juan Piña-Crespo ,Maria Talantova ,Swagata Ghatak ,Dorit Trudler ,Lauren N Carnevale ,Scott R McKercher ,Malina A Bakowski ,Jolene K Diedrich ,Amanda J Roberts ,Ashley K Woods ,Victor Chi ,Anil K Gupta ,Mia A Rosenfeld ,Fiona L Kearns ,Lorenzo Casalino ,Namir Shaabani ,Hejun Liu ,Ian A Wilson ,Rommie E Amaro ,Dennis R Burton ,John R Yates 3rd ,Cyrus Becker ,Thomas F Rogers ,Arnab K Chatterjee ,Stuart A Lipton

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice

突变型TAU的生理表达会损害星形胶质细胞活性,并加剧5xFAD小鼠的β-淀粉样蛋白病理。

Dorit Farfara # ,Meital Sooliman # ,Limor Avrahami ,Tabitha Grace Royal ,Shoshik Amram ,Lea Rozenstein-Tsalkovich ,Dorit Trudler ,Shani Blanga-Kanfi ,Hagit Eldar-Finkelman ,Jens Pahnke ,Hanna Rosenmann ,Dan Frenkel

Mechanistic insight into female predominance in Alzheimer's disease based on aberrant protein S-nitrosylation of C3

基于C3蛋白异常S-亚硝基化的阿尔茨海默病女性高发机制研究

Hongmei Yang ,Chang-Ki Oh ,Haitham Amal ,John S Wishnok ,Sarah Lewis ,Emily Schahrer ,Dorit Trudler ,Tomohiro Nakamura ,Steven R Tannenbaum ,Stuart A Lipton

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome

迷迭香二萜类化合物鼠尾草酸通过激活NRF2拮抗NLRP3炎症小体,在阿尔茨海默病、帕金森病和新冠后遗症的治疗中具有潜在的治疗用途

Satoh, Takumi; Trudler, Dorit; Oh, Chang-Ki; Lipton, Stuart A

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

二甲双胍通过抑制线粒体ATP和DNA合成,阻断NLRP3炎症小体的激活和肺部炎症。

Hongxu Xian ,Yuan Liu ,Alexandra Rundberg Nilsson ,Raphaella Gatchalian ,Timothy R Crother ,Warren G Tourtellotte ,Yi Zhang ,German R Aleman-Muench ,Gavin Lewis ,Weixuan Chen ,Sarah Kang ,Melissa Luevanos ,Dorit Trudler ,Stuart A Lipton ,Pejman Soroosh ,John Teijaro ,Juan Carlos de la Torre ,Moshe Arditi ,Michael Karin ,Elsa Sanchez-Lopez

NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

NitroSynapsin可改善阿尔茨海默病hiPSC模型中过度同步的神经网络活动

Swagata Ghatak ,Nima Dolatabadi ,Richard Gao ,Yin Wu ,Henry Scott ,Dorit Trudler ,Abdullah Sultan ,Rajesh Ambasudhan ,Tomohiro Nakamura ,Eliezer Masliah ,Maria Talantova ,Bradley Voytek ,Stuart A Lipton

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

可溶性α-突触核蛋白-抗体复合物激活hiPSC衍生小胶质细胞中的NLRP3炎症小体

Trudler, Dorit; Nazor, Kristopher L; Eisele, Yvonne S; Grabauskas, Titas; Dolatabadi, Nima; Parker, James; Sultan, Abdullah; Zhong, Zhenyu; Goodwin, Marshall S; Levites, Yona; Golde, Todd E; Kelly, Jeffery W; Sierks, Michael R; Schork, Nicholas J; Karin, Michael; Ambasudhan, Rajesh; Lipton, Stuart A