日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触。

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Cedeño Kwong Claudia, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids.

MEF2C自闭症患者hiPSC神经元和脑类器官中miRNA表达和兴奋失调

Trudler Dorit, Ghatak Swagata, Bula Michael, Parker James, Talantova Maria, Luevanos Melissa, Labra Sergio, Grabauskas Titas, Noveral Sarah Moore, Teranaka Mayu, Schahrer Emily, Dolatabadi Nima, Bakker Clare, Lopez Kevin, Sultan Abdullah, Patel Parth, Chan Agnes, Choi Yongwook, Kawaguchi Riki, Stankiewicz Pawel, Garcia-Bassets Ivan, Kozbial Piotr, Rosenfeld Michael G, Nakanishi Nobuki, Geschwind Daniel H, Chan Shing Fai, Lin Wei, Schork Nicholas J, Ambasudhan Rajesh, Lipton Stuart A

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Kwong Claudia Cedeño, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer's Disease, Parkinson's Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome

迷迭香二萜类化合物鼠尾草酸通过激活NRF2拮抗NLRP3炎症小体,在阿尔茨海默病、帕金森病和新冠后遗症的治疗中具有潜在的治疗用途

Satoh, Takumi; Trudler, Dorit; Oh, Chang-Ki; Lipton, Stuart A

Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

可溶性α-突触核蛋白-抗体复合物激活hiPSC衍生小胶质细胞中的NLRP3炎症小体

Trudler, Dorit; Nazor, Kristopher L; Eisele, Yvonne S; Grabauskas, Titas; Dolatabadi, Nima; Parker, James; Sultan, Abdullah; Zhong, Zhenyu; Goodwin, Marshall S; Levites, Yona; Golde, Todd E; Kelly, Jeffery W; Sierks, Michael R; Schork, Nicholas J; Karin, Michael; Ambasudhan, Rajesh; Lipton, Stuart A

Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases

用于神经退行性疾病药物研发的新兴hiPSC模型

Trudler, Dorit; Ghatak, Swagata; Lipton, Stuart A

Novel Direct Conversion of Microglia to Neurons

小胶质细胞向神经元的新型直接转化

Trudler, Dorit; Lipton, Stuart A

MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress.

MEF2D 单倍体不足会下调 NRF2 通路,使感光细胞易受光诱导的氧化应激影响

Nagar Saumya, Noveral Sarah M, Trudler Dorit, Lopez Kevin M, McKercher Scott R, Han Xuemei, Yates John R 3rd, Piña-Crespo Juan C, Nakanishi Nobuki, Satoh Takumi, Okamoto Shu-Ichi, Lipton Stuart A

Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency

Mef2缺陷中抵抗年龄相关性光感受器退化的分子通路

Nagar, Saumya; Trudler, Dorit; McKercher, Scott R; Piña-Crespo, Juan; Nakanishi, Nobuki; Okamoto, Shu-Ichi; Lipton, Stuart A

Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application

神经淀粉样变性疾病中胶质细胞中Toll样受体的表达和信号传导:面向未来的治疗应用

Trudler, Dorit; Farfara, Dorit; Frenkel, Dan